Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Hemichannel"”.
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Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease
In vertebrates, connexin hemichannels in the plasma membrane dock head-to-head with their counterparts in adjacent cells to form gap junction channels, allowing direct cell-cell transfer of electric and chemical/metabolic signals. Each hemichannel comprises a hexamer of connexin proteins which …
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Function Study of Atrial Fibrillation-Linked Connexin Mutants and Heterotypic Docking Compatibility of Cardiac Connexins
… L221I and wildtype Cx40, suggesting increased hemichannel opening probability. A novel AF-linked Cx45 mutant (M235L) was found to impair GJ function. These alterations in hemichannel or GJ function might play a role in promoting AF. The atria express Cx40 and Cx43 abundantly with low levels of …
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Mechanisms of Calcium Wave Initiation and Propagation in Astrocytes
… system. Cx43 channels also exist, however, in a hemichannel configuration that gates between the cytoplasm and the extracellular space.</p> <p>The main discovery of this dissertation is that it is the hemichannel configuration that is required for Ca<sup>2+</sup> waves. Specifically, Cx43 …
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Vascular breakdown in diabetic retinopathy: Role of connexin43 and possible interventions
… Recent studies have shown that connexin43 hemichannels play a role in the pathogenesis of chronic inflammatory diseases and blocking these channels can alleviate vascular leak and inflammation associated with these conditions. However, there is conflicting literature with regards to …
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Identificaiton of the pore-lining helices of connexin 43 gap-junctional hemichannels
… by head-to-head docking of two gap-junctional hemichannels from adjacent cells. The hemichannels are hexamers of connexins, proteins that have four transmembrane helices. The transmembrane helices that line the gap-junctional pore have not been identified, and their identification was the main …
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Cell penetrating peptide for ocular drug delivery
… been linked to uncontrolled Connexin43 (Cx43) hemichannel (HC) opening in the retina and the vasculature of the eye, leading to cell death, vascular permeability and vision loss. Cx43 HC block has proven to be effective in inhibiting the inflammatory cascade in various in vitro and in vivo …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… that NO mediated S-nitrosation of Cx43 promote a hemichannel state over a gap junction state. Together this research indicates the potential of β3AR as a target for developing tocolytic strategies involving combination therapy with mechanisms that have additive effects.
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Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
… coupling between paired N2A cells. Enhanced hemichannel function was observed for the Cx40-F30L mutant, leading to cell death in Xenopus oocytes. Increased sensitivity to intracellular pH caused closure of gap junction channels composed of Cx40-G311S or Cx40-R113S. Intracellular localization …
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Functions of connexin 46 in lens and solid tumors during hypoxia
… family. Six connexin monomers assemble into a hemichannel, which is transported to the cell membrane. An opposing cell membrane containing compatible connexin hemichannels is located and connected, forming an intercellular dodecameric protein complex. This results in a protein channel that …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… It has also been found that connexin hemichannels play a role in the disease‟s pathology. In the normal eye, hemichannels are in a closed state or docked together forming gap junctions for intercellular communication. However, there is undocking of hemichannels and abnormal opening …
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
… into a hexameric connexon, also known as a hemichannel, and transport to plasma membranes along microtubules finally forming a gap junction between cells. In the inner ear, gap junctions play a critical role in the generation the endocochlear potential, which is required for normal hearing. …