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Showing 1 to 3 of 3 for “"Hemicalide"”.
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Studies Towards the Total Synthesis of Hemicalide
The discovery of a novel marine natural product hemicalide (1), with promising anticancer activity, has sparked interest in elucidating its full three-dimensional structure. Studies into the total synthesis and stereochemical assignment of the complex polyketide structure of hemicalide are …
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The Synthesis-Enabled Stereochemical Elucidation of the Marine Natural Products Hemicalide and Phormidolide A
… efforts towards two marine natural products, hemicalide (1) and phormidolide A (2), with the end goal of establishing and/or confirming the compound’s full stereochemistry. Hemicalide’s low isolation yield from its marine sponge source meant that none of the 21 stereocenters were assigned in …
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Towards the Structural Elucidation and Total Synthesis of Hemicalide: Assignment of the C29-C46 Region
… assignment of the C29-C46 region of hemicalide (1), a complex, highly bioactive polyketide marine natural product. Chapter one introduces the complex polyketide hemicalide and summarises previous work on this natural product. Hemicalide displays impressive bioactivity, registering …