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Showing 1 to 2 of 2 for “"Hemgn"”.
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Functional Study of Hemogen Knockout Mouse Model
<p>Mouse Hemogen (Hemgn) is regarded as a homologue of human Erythroid Differentiation Associated Gene (EDAG). EDAG overexpression has been postulated for association with some leukemia cases. Meanwhile, Hemgn has been found to contribute to Hoxb4 mediated hematopoietic stem cell expansion. Based …
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Identification of the Downstream Effector Genes Involved in HOXB4-Induced Expansion of Hematopoietic Progenitor Cells
… Among them, we show that <em>Hemogen</em> (<em>Hemgn</em>), encoding a nuclear protein specifically expressed in hematopoietic stem and progenitor cells, is a direct transcriptional target of HOXB4, and that HOXB4 binds to the promoter region of <em>Hemgn</em>. More importantly, when …