Global ETD Search
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Showing 1 to 4 of 4 for “"Hemeprotein"”.
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Investigating the Interactions Between the Thiolate Ligand and Mutants of a Conserved Tryptophan in the Proximal Heme Pocket of the Oxygenase Domains of Endothelial and Staphyloccus Aureus Nitric Oxide Synthases
The electronegativity of thiolate ligation in the hemeprotein nitric oxide synthase (NOS) proteins has been identified as an influence on autoinhibition in this enzyme. The mutation of a conserved tryptophan residue, which hydrogen bonds to the coordinating thiolate ligand and therefore influences …
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Spectroscopic characterization of iron-oxygen intermediates in human aromatase (CYP19A1)
… cancer prognosis. CYP19A1 is a membrane-bound hemeprotein with a rich spectroscopic landscape thus affording an opportunity to apply a repertoire of biophysical approaches to help piece together a reaction mechanism. I used the Nanodisc technology to stabilize CYP19A1 in its native …
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Novel time resolved optical and machine learning methods for label free biomedical imaging
… Cytochromes are a particular type of Hemeprotein that are comprised of iron porphyrin and are primarily responsible for electron transport within the ETC of Mitochondria. We utilize a two-color visible wavelength pump-probe technique that can roughly detect up to 10-6 absorption …
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Design, Synthesis and Characterization of Heme-proteins: Developing Potential Catalysts for Bio-remediation
The next generation of toxic chemicals and hazardous wastes from sophisticated chemical industries will demand the environmental agencies to employ biological methods over the conventional physical and chemical remediation methods. Over the past decade, natural metallo-enzymes have been identified …