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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Heme oxygenase-1"”.
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
In the past few years, heme oxygenase (HO) has been regarded as a potential pharmacological target, especially the inducible isoform, heme oxygenase-1 (HO-1). HO catalyzes the rate-limiting step of endogenous heme degradation, releasing carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… enzymes, including the endogenous antioxidant heme oxygenase-1 (HO-1), with activation of nuclear factor E2 p45-related factor 2 (Nrf2), and protection from oxidative stress induced apoptosis. In cultured cardiomyocytes, treatment with Protandim was associated with activation of Nrf2 and a …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… HAND and reduced protein expression of brain heme oxygenase-1 (HO-1), a highly inducible detoxifying enzyme with antioxidant and anti-inflammatory functions. We further demonstrated that HIV infection of macrophages reduces HO-1 RNA and protein and that this HO-1 loss is associated with …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… chronic inflammation, and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. Our analysis of HO-1 expression in the brain …
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Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
Hämoxygenase-1 (HO-1) ist das Schlüsselenzym, das den Abbau von Häm zu Carbonmonixid (CO), zweiwertigem Eisen (Fe2+) und Biliverdin katalysiert. Wegen der facettenreichen anti-entzündlichen Wirkweisen dieser Produkte, wurde vorgeschlagen daß HO-1 in der Akuten-Phase Reaktion, der Abwehrreaktion des …
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Synthesis and Evaluation of Naturally Occuring Halogenated Bipyrroles in a Relevant Marine Species, Fundulus Heteroclitus
… on examining the effects of HDBP's to inhibit heme oxygenase (HO), the enzyme responsible for the catalytic oxidation of heme, which may account for the accumulation of porphryrins in hepatocyte models. Within the current study we have synthesized and characterized several natural product …
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Biliverdin reductase in cardiovascular inflammation
… Reductase (BVR) functions downstream of Heme Oxygenase 1 (HO-1) in the process of heme degradation and catalyses the reduction of biliverdin to bilirubin. For over thirty years, BVR was regarded as rather a trivial enzyme whose only known function was to aid heme disposal. Over the last …
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Oil palm phenolics suppresses oxidative stress and inflammation
… protein expression of activated enzymes such as Heme Oxygenase 1. An image analysis assay was developed to study the effects of OPP on cell size, morphology and phagocytosis of Lipopolysaccharides (LPS) induced inflammation in BV-2 microglial cells. This study was followed by experiments to …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… the oxidative stress protective enzymes heme oxygenase-1 (HO-1) and glutathione S-transferase (GSTP1) proteins in RPE cells by 1.5- to 2-fold over untreated cells in 6 hours and, at pharmacologic doses, up-regulate HO-1 as much as 10-fold over a 24-hour period. Bilberry anthocyanins and …
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Targeting Nrf2 in Inflammation and Cancer
… it was a much more powerful activator of heme oxygenase-1 than any diallyl sulfides reported to date. Nrf2 is regulated by Keap1, which targets it for degradation. Disruption of the Nrf2/Keap1 interaction results in Nrf2 activation. In this study, a novel cell-penetrating peptide, based on …
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… of cGMP could be demonstrated. The induction of heme oxygenase-1 by ANP might not be responsible for the observed hepatoprotection, since inhibition of HO-1 activity did not abrogate the ANP effect. Interestingly, cell-type specific evaluation detected that induction of HO-1 in livers by ANP is …
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Bioavailability of blueberry-derived phenolic acid metabolites and their activity in endothelial cells
… important for vascular protection such as heme oxygenase-1 (HO-1) which removes heme released as a product of protein catabolism and glutamate-cysteine ligase modifier subunit (GCLM) which is important for glutathione synthesis. Blueberry-derived phenolic acid aglycones were able to …
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HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants
… a transplanted kidney. One enzyme of interest, heme oxygenase-1 (HO-1), degrades heme and protects against the oxidative stress that occurs secondary to IRI. Clinical renal recipients with higher HO-1 levels have improved graft function post transplant. Heme arginate (HA), a form of hemin, which …
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HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
… in the periphery of the hematoma, enriched heme oxygenase 1 (HO-1) expression and localised thrombosis were observed in these embryos. I show that the patterning and distribution of catecholaminergic neurons, response to sensory stimulus and swimming speed were impaired as a consequence of …
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Role of the macrophage in acute kidney injury
… The potential for the key antioxidant enzyme Heme oxygenase-1 (HO-1) to protect renal function was also examined in aged mice using hemearginate (HA) - a potent HO-1 inducer. Echoing epidemiological studies in humans aged mice had increased susceptibility to IRI, whilst failing to induce …
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Redox mechanisms in retinal cells
… induced the Nrf2- driven cellular anti-oxidant heme oxygenase-1 (HO-1) in the human ARPE-19 retinal epithelial cell line In contrast, SFN significantly increased HO-1 and NAD(P)H:quinine oxidoreductase 1 (NQO1), but not ferritin or Thioredoxin (Trx1) expression in MIO-M1 cells, which are Nrf2 …
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Μελέτη του μεταγραφικού παράγοντα NRF2 ως διαμεσολαβητή της δράσης των στατινών
… και το mRNA δύο γνωστών στόχων του Nrf2, ΗΟ-1 (Heme Oxygenase 1) και GPX-2 (Glutathione Peroxidase 2) αυξήθηκε. Σε ST-2 κύτταρα μόνιμα διαμολυσμένα με πλασμίδιο που φέρει αλληλουχία DNA στην οποία προσκολλάται ο Nrf2 (ARE-Antioxidant Response Element) (ARE-ST2 κύτταρα), η σιμβαστατίνη αύξησε τη …
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Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
… oxidative stress such as glutathione, NOx, and heme oxygenase-1 confirmed that the oxidative balance was shifted to a pro-oxidative status both in ovalbumin (OVA) sensitized mice and in those exposed to SO2 in combination with OVA. Treatment with anti-oxidants presented a complex picture of …
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