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Showing 1 to 20 of 25 for “"Hematopoietic stem and progenitor cells"”.
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Substrate elasticity regulates the biophysical properties of hematopoietic stem and progenitor cells
… decouple the effects of substrate elasticity, ligand concentration, and dimensionality on hematopoietic stem cell (HSC) fate (quiescence, self-renewal, differentiation, mobilization, homing, and apoptosis), HSCs harvested from C57B6 mouse femurs and tibias were cultured in or on top of collagen …
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Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable …
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Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… marrow. As such, at steady state, a majority of hematopoietic stem and progenitor cells: HSPCs) are tightly held within specialized areas of the bone marrow collectively referred to as the `hematopoietic stem cell niche.' In response to various forms of stress, such as infection or hemorrhage, or …
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Identification of the Downstream Effector Genes Involved in HOXB4-Induced Expansion of Hematopoietic Progenitor Cells
… factor family, promotes expansion of hematopoietic stem and progenitor cells both<em>in vivo </em>and <em>in vitro</em>.<em> </em>However, the molecular mechanisms underlying this effect are not well understood. In order to identify direct target genes of HOXB4 in primary murine …
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DEVELOPMENT OF A 3D ZWITTERIONIC HYDROGEL SYSTEM FOR CELL CULTURE AND EXTRACELLULAR VESICLES
… method of intercellular communication between cells, they are essential in various biological processes and possess significant therapeutic potential. Maintaining high-quality control of donor cell cultures and EVs is critical for effective loading and delivery.[1] However, current methods for …
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Dissecting The Mechanisms of Venetoclax Resistance In Myelodysplastic Syndromes
… (MDS) are a class of heterogeneous clonal hematopoietic disorders. The current standard of care for MDS is the hypomethylating agent (HMA)-based therapy. However, only 50 percent of the patients respond, with transient effects and no approved second-line treatment options after their …
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PRE-CLINICAL MODELING OF CELL AND GENE THERAPY OF FANCONI ANEMIA
… as bone marrow failure, physical anomalies, and increased cancer risk. While it has long been recognized that FA patients exhibit compromised hematopoiesis and have reduced frequencies of immunophenotype-defined hematopoietic stem and progenitor cells (HSPCs), the number of functional stem …
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Integrin α2 and Akt in early hematopoiesis
… is a tightly regulated process in which hematopoietic stem cells reside at the apex of the hierarchy, and produce all kinds of mature blood cells by differentiation to replenish the cell loss in homeostasis and acute injury. In past few decades, much effort has been made to purify …
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Improving Leukocyte Recovery Through Physiologically Relevant Oxygen Expansion after Hematopoietic Stem Cell Transplantation
Rapid recovery of lymphocytes post hematopoietic stem cell transplantation (HCT) is correlated with positive patient outcome in treatments of hematologic disease. Few effective clinical therapies exist to enhance lymphocyte recovery, indicating a clear unmet need. Ex vivo expansion of umbilical …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
The development and function of hematopoietic stem cells (HSCs) is regulated by numerous signaling pathways including Akt-mechanistic target of rapamycin complex1 (mTORC1) pathway. Dysregulation of this pathway results in impaired HSC function and contributes to the development of hematologic …
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The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… normally occurs in bone marrow, where hematopoietic stem cells: HSC) reside within a specialized microenvironment. At steady state, hematopoiesis state is regulated such that immature hematopoietic stem and progenitor cells: HSPC) are restricted to the bone marrow and are rarely …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
… fibrous repair tissue. Since mesenchymal stem cells (MSCs) play a vital role in the natural development, maintenance, and repair of cartilage and bone, tissue engineering strategies to enhance functional regeneration by modulating MSC differentiation are a promising alternative to the …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
… factors mediate their effect. An improved understanding of susceptibility factors and the biological processes in which they act may lead to the development of t-AML prevention strategies. In this thesis work, we identified expression networks that are associated with t-AML susceptibility in mice. …
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Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… lingering near 20%. Acquiring a deeper understanding of molecular underpinnings of leukemogenesis will provide a basis for developing more effective therapeutic strategies for patients with AML.</p> <p>Here, we identified overexpression of hnRNP K as a recurrent abnormality in a subset (~20%) …
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Cold Shock Domain Proteins in Normal and Leukemic Hematopoiesis
… functional genes that contain CSDs in humans and mice: YBX1, MSY4, MSY2, and CSDE1. YBX1 is overexpressed in most cancers, and is frequently associated with poor outcomes and chemotherapy resistance. Both YBX1 and MSY4 are highly expressed in normal hematopoietic progenitors, and both are …
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Hematopoiesis: Functional Insights by Cell Fate Conversion
… or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… are the defining lesion in 5% of pediatric and adult B-cell acute lymphoblastic leukemia and tumors are characterized by aberrant myeloid marker expression. Additionally, ZNF384 rearrangements are the defining lesion in nearly half of pediatric B/myeloid mixed phenotype acute leukemia. These …
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Eliminating Acute Myeloid Leukemia Stem Cells by Targeting the Niche Microenviromnent: Co-Inhibition of TNF/IL1- JNK and NF-κb
<p>Leukemia Stem Cells (LSCs) from Acute Myeloid Leukemia (AML) require the activity of the transcription factor NF-kB to maintain stemness and drive tumor formation. Blocking NF-kB can preferentially eliminate LSCs in vitro with minimal effects on healthy Hematopoietic Stem and Progenitor Cells …
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The influence of exercise training on the bone marrow microenvironment in obesity and cancer
Hematopoiesis is the process by which mature cells of the hematopoietic system are replenished. Hematopoietic stem and progenitor cells (HSPCs) are responsible for the maintenance and generation of blood cells in circulation. HSPCs primarily reside within the bone marrow (BM) in distinct niches …
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