Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Hematopoietic cell"”.
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Metabolic and genetic factors guiding hematopoietic cell fate
… development requires precise control over cellular identity, and a wide range of diseases is characterized by altered differentiation states. Understanding the environmental factors that interplay with gene expression networks to regulate cell state holds immense potential for both basic …
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Validation of the adapted CogState brief battery in hematopoietic cell transplant patients
… has documented cognitive deficits in adult hematopoietic cell transplant (HCT) survivors across the transplant trajectory, primarily occurring in memory, executive function, attention, and processing speed. Although HCT-associated cognitive decline occurring within one year of …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
Hematopoietic stem cells (HSC) are multipotent and possess self-renewal capacity. Thus, they can sustain a life-long hematopoiesis and are also capable of restoring the hematopoietic system when transplanted to a patient. In allogeneic hematopoietic stem cell transplantation (HSCT), a potent …
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Exploring nanoparticles' interactions with blood proteins and visualizing the heterogeneity within hematopoietic cell populations
… of targeted drug delivery by recognizing target cells and selectively delivering the therapeutic drugs to these cells. However, functionalized-NPs often have low targeting efficiency when they are administered in vivo. One of the major causes of this unfavorable outcome is that proteins and other …
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Single-cell analysis of hematopoietic cell fate on niche-mimetic platforms using Raman microspectroscopy
… controlled and reproducible expansion of stem cells ex vivo. Hematopoietic stem cells (HSCs) are the best-studied class of tissue-restricted stem cells and their microenvironment in vivo has also been the subject of considerable research. Although a host of cellular, molecular and physical cues …
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Incidence rate of fluoroquinolone resistant gram-negative rod bacteremia among allogeneic hematopoietic cell transplant patients during an era of levofloxacin prophylaxis
… rates of gram-negative rod (GNR) bacteremia in hematopoietic cell transplant (HCT) recipients. We set out to describe time trends in the incidence rates (IR) of GNR bacteremia and FQ-resistant GNR bacteremia in HCT recipients during an era of levofloxacin prophylaxis. <bold>Methods:</bold> We …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… determined that lineage-negative (lin-) hematopoietic progenitors expressing E2A-PBX1 expression fail to repopulate the B-lymphoid lineage when transplanted into irradiated recipient mice. Furthermore, E2A-PBX1 expressing, lin- fetal liver progenitors (FLPs) fail to differentiate into …
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ΜΕΛΕΤΗ ΤΩΝ ΜΕΤΑΒΟΛΩΝ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΠΛΗΘΥΣΜΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΛΕΜΦΟΚΙΝΩΝΣΕ ΑΡΡΩΣΤΟΥΣ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΜΕΤΑ ΑΠΟ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ
… GLOBULIN. LYMPHOTYPE, LYMPHOKINE PRODUCTION AND HEMATOPOIETIC CELL NUMBER WERE MEASURED BEFORE AND 3 MONTHS AFTER THERAPY. IN ALL HEMATOLOGIC RESPONDERS THE NUMBER OF TAC+ LYMPHOCYTES AFTER ATG THERAPY WAS IN THE NORMAL RANGE, BUT HALF OF THE 12 NON-RESPONDING PATIENTS CONTINUED TO HAVE …
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The role of HLA-G in bone marrow transplantation
… putative role of this molecule in the allogeneic hematopoietic cell transplantation setting. The percentage of HLA-G+ cells in peripheral blood of healthy donors and allo-transplanted patients was evaluated by flow cytometry. Their immunoregulatory and immunotolerogeneic properties were …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… in elevated levels of c-Mpl transcripts and cell surface protein on primary murine HSPC as well as increased phosphorylation of STAT5, which is known to be activated down-stream of c-MPL signaling. Blocking c-MPL signaling by removal of its ligand, thrombopoietin (TPO), or addition of a c-MPL …
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Critical Illness in Patients with Hematologic Malignancies
… with hematologic malignancies who received hematopoietic cell transplantation. Synthesis: Between April 1st 2006 and March 31st 2017, 87965 patients were diagnosed with hematologic malignancy in Ontario. The one-year incidence of ICU admission was 13.9% (median time to ICU 35 days), ranging …
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
High-affinity antibody production, T cell activation, and Interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specific PTPN22 encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and …
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Genetic study of hematopoiesis development by two zebrafish mutants: Ugly duckling and tc-244
… process from which major lineages of blood cells are generated and subsequently mature into functionally active cells. Although it is widely known that vertebrate hematopoiesis has two phases: a primitive phase is followed by the other definitive phase, the underlying molecular mechanism …
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Characterization of Thy-1 expression on human hematopoietic cells
Hematopoietic stem cells have extensive proliferative capacity and the ability to produce daughter cells of all hematopoietic lineages. However, their characterization is complicated by their low frequency and the heterogeneous cellular composition of the tissues in which they are found. The …
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Investigation of Bone Marrow Hematopoietic Stem Cell Migration during Inflammation in BALB/c Mice /
… anti-inflammatory effect of murine bone marrow hematopoietic stem cells and their migration in the BALB/c mouse contact hypersensitivity model in vivo. It was found that isolated hematopoietic cell populations had a significant anti-inflammatory effect and inhibited the edema. The studies showed …
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BALB/c pelių kaulų čiulpų hemopoetinių kamieninių ląstelių migracijos tyrimai uždegimo metu /
… anti-inflammatory effect of murine bone marrow hematopoietic stem cells and their migration in the BALB/c mouse contact hypersensitivity model in vivo. It was found that isolated hematopoietic cell populations had a significant anti-inflammatory effect and inhibited the edema. The studies showed …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… cis-regulatory elements is central to establish cellular identity and function. Understanding this regulatory logic is critical for deriving select cell types in vitro for translational applications. The human hematopoietic system has long been a model system and an important source for adoptive …
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Development of single-cell Raman spectroscopy for noninvasively screening the differentiation of living stem and progenitor cells in biomaterial platforms for 2D and 3D cell culture
Stem and progenitor cells' capabilities to self-renew, differentiate, and proliferate within their native tissue made them the subject of ongoing studies to understand the mechanisms of such processes and their potential use as therapeutics. Regenerative medicine encompasses the idea of treating …
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