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Showing 1 to 20 of 33 for “"Hematopoietic Stem Cell Transplantation"”.
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Saliva and oral mucositis after hematopoietic stem cell transplantation
Contains fulltext : 225513.pdf (Publisher’s version ) (Open Access)
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Improving Leukocyte Recovery Through Physiologically Relevant Oxygen Expansion after Hematopoietic Stem Cell Transplantation
Rapid recovery of lymphocytes post hematopoietic stem cell transplantation (HCT) is correlated with positive patient outcome in treatments of hematologic disease. Few effective clinical therapies exist to enhance lymphocyte recovery, indicating a clear unmet need. Ex vivo expansion of umbilical …
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Exploring Prevalence and Management of Anxiety in Children and Adolescents with Cancer or Undergoing Hematopoietic Stem Cell Transplantation
… and adolescents with cancer or undergoing hematopoietic stem cell transplantation (HSCT), to estimate the burden of anxiety and to describe guideline recommendations for assessing and managing anxiety in this population. The three papers comprising this dissertation established several key …
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UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
Natural Killer (NK) cells are potent members of the innate immune system, as they are endowed with the capacity of sensing and eliminating tumor-transformed and viral infected cells by integrating a plethora of inhibitory and activating signals coming from a repertoire of germline encoded receptors …
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Treatment Outcomes in Children with Very High Risk Acute Lymphoblastic Leukemia Intended to Treat with Allogeneic Hematopoietic Stem Cell Transplantation
… of intensive chemotherapy. Recently, allogeneic hematopoietic stem cell transplantation (Allo-HSCT) was use to treat the patients with VHR ALL. We studied the clinical course and outcomes of children with VHR ALL intended treat with Allo-HSCT after chemotherapy. 16 children who were diagnosed as …
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Hematology-Oncology Transplant Nurses Experience Through the Moral Labyrinth of Integrating Palliative Care
… of palliative care for patients undergoing hematopoietic stem-cell transplantation. Findings revealed a complex understanding of palliative and end-of-life care, highlighting the emotional and moral challenges facing HOT nurses. The study provides new insights into how these nurses navigate …
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Adesão ao tratamento farmacológico no pós-transplante de células-tronco hematopoéticas
Introduction: Post-hematopoietic stem cell transplantation is a period in which adherence to pharmacological treatment is crucial to prevent complications such as graft-versus-host disease and graft failure. Therefore, the following research questions were formulated: What is the degree of …
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Sviluppo di vettori virali per la terapia genica della β−Talassemia
… no curative therapy other than allogeneic hematopoietic stem cell transplantation. This therapeutic option, however, applies only to the minority of thalassemia patients who have an HLA−matched bone marrow donor. Gene therapy by the delivery of a regulated globin gene to autologous …
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Engineering cell-based micropharmacies for in vivo protein replacement therapy
… and caretakers. To overcome these limitations, cell-based micropharmacies have emerged as a promising platform for continuous therapeutic protein expression and targeted delivery in vivo. Utilizing the innate properties of specific cell subsets, such as T cells, B cells, and hematopoietic stem …
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CaMKIIbeta in Pain and Addiction
… and neuropathic pain models. I employed hematopoietic stem cell transplantation to induce sickle cell in transgenic mice and discovered that CaMKIIβ mediates sickle cell disease (SCD) pain. In addition, I studied the contribution of CaMKIIβ to opioid induced hyperalgesia (OIH) and showed …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… remains the major complication after allogeneic hematopoietic stem cell transplantation (HSCT), resulting from immunological attack on target organs such as gastrointestinal (GI) tract, liver and skin from donor allogeneic T cells. The most common treatment for GVHD is immunosuppressive drugs …
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Insights into the clonal inventory of gene corrected human SCID-XI hematopoiesis
… introduces a stable molecular marker into the cellular genome in the form of a genomic-proviral fusion sequence which can be passed on unmodified to all the progenies of a transduced cell. Retroviral integration site analysis provides a powerful method to study the clonal composition of in vivo …
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Donor lymphocyte infusion after allogeneic stem cell transplantation in children
… marrow failure syndrome following allogeneic hematopoietic stem cell transplantation (allo HSCT). However, DLI is limited by the development of graft-versus-host disease (GVHD)and marrow aplasia, and the efficacy of DLIis not defined in children. So we evaluate DLI for last decade, and …
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THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… including autoimmune and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout the skin to …
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Pediatric sequential organ failure assessment score in a congenital heart defect population
… Researchers recently created a new scoring system for characterizing organ dysfunction in critically ill pediatric patients, named the pSFOA (pediatric sequential organ failure assessment). Support for applying this scoring system in pediatric patients who suffer from cyanotic and acyanotic …
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Understanding Ontogeny and Optimizing Strategies to Promote Hematopoietic Engraftment Following In Utero Transplantation
Early diagnosis and in utero hematopoietic stem cell transplantation (IUHSCTx) have the potential to reduce fetal/neonatal morbidity/mortality due to hematological and immunological disorders. In some instances, IUHSCTx could also prevent disease-dependent organ damage/failure that many genetic …
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Validação de conteúdo do diagnóstico de enfermagem proteção ineficaz em pacientes submetidos ao transplante de células tronco hematopoiéticas
… foi realizada com os descritores “Protection” e “hematopoietic stem cell transplantation” utilizando o recorte temporal de cinco anos. A amostra final da revisão foi composta por 16 artigos, sendo possível identificar: três atributos, quinze antecedentes e onze consequentes. Elaborou-se também um …
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The Role Of Inflammation In Pathogenesis And Treatment Of Globoid-Cell Leukodystrophy
Globoid-cell leukodystrophy: GLD, Krabbe's disease) is an autosomal recessive disease caused by a deficiency of the lysosomal enzyme galactosylceramidase: GALC). It results in altered catabolism of the myelin lipid Galactosylceramide. The disease predominantly affects the white matter of the CNS …
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