Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 408 for “"Hematopoietic"”.
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Regulation of Hematopoietic Stem Cells
This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate …
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ULTRASTRUCTURAL CHANGES IN FROZEN HEMATOPOIETIC TISSUE.
ULTRASTRUCTURAL CHANGES IN FROZEN HEMATOPOIETIC TISSUE.
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Systems Biology Analyses of Hematopoietic Cells
The focus of my thesis is to apply systems biology approaches to obtain a better understanding of complex cellular systems. In particular, my work concentrates on the function of haematological cells. The first part of the thesis applies a novel, predictive strategy to identify new regulators of a …
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Genomic architecture of the aging hematopoietic system
Hematopoiesis is a dynamic, yet tightly regulated process continuously replenishing populations of cells, including those with immune functions, that circulate in peripheral blood. Aging is associated with changes in hematopoiesis, resulting in altered composition and reduced function of immune …
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The Role of Meis1 in Hematopoietic Development
… has been established, its function in hematopoietic development is still unclear. Previous lineage tracing demonstrated that <italic>Mesp1</italic> activity labeled endothelial cells of embryonic dorsal aorta, which recently was shown to give rise to definitive hematopoietic …
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Identification of Unique Hematopoietic Stem Cell Properties
Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and …
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Molecular Mechanisms in Hematopoietic Stem Cell Aging
… tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to …
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Isolation and characterization of primitive hematopoietic cells
… recently described. SP cells from other human hematopoietic cell sources, such as BM from normal donors and patients with hematological malignancies, or mobilized PB from donors and patients, however, have not been characterized extensively. We therefore sought to characterize SP cells from …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… system are all produced from blood forming or hematopoietic stem cells (HSCs). HSCs have the unique property of self renewal, ensuring life-long replenishment of all the blood cell types. Hematopoietic growth factors, so called cytokines, have previously been demonstrated to be important for …
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Targeting the hematopoietic stem cell to correct osteopetrosis
… the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a rare congenital disorder associated with an increased number of non-functional osteoclasts and the absence of bone resorption results in accumulation of sclerotic bone leading to …
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Role of epigenetics in hematopoietic stem cell development
… treatments, such as molecules which stimulate hematopoietic stem cell (HSC) formation without the need for a donor. Therefore, a study was initiated to use human-induced pluripotent stem cell (hiPSC) technology to make a patient-derived, personalized HSC. Epigenetic regulators are divided into …
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A microfluidic platform for hematopoietic stem cell separation
… based silicon micropost device for hematopoietic stem cell enrichment is discussed, which demonstrates how innovations in microfluidics can revolutionize current clinical therapies. Appropriate surface chemistry for robust immobilization of proteins on the surface of different …
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Metabolic and genetic factors guiding hematopoietic cell fate
… cell state transitions across multiple hematopoietic cell types, with implications for how such processes may underlie developmental and disease states and be harnessed for therapeutic benefit.
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Hematopoietic Stem Cells and Progenitors in Murine Autoimmune Arthritis
… been adequately explored. We have studied the Hematopoietic System, with particular emphasis on Hematopoietic Stem Cells: HSCs) and Progenitors, in a spontaneous murine autoimmune arthritis model. We found that these mice have a systemic increase in myeloid cells, which correlated with an …
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Refining Our Understanding of the Hematopoietic Stem Cell Niche
… major therapeutic goal of studying blood-forming hematopoietic stem cells (HSCs) is to understand the mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat …
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Characterization of Thy-1 expression on human hematopoietic cells
Hematopoietic stem cells have extensive proliferative capacity and the ability to produce daughter cells of all hematopoietic lineages. However, their characterization is complicated by their low frequency and the heterogeneous cellular composition of the tissues in which they are found. The …
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Saliva and oral mucositis after hematopoietic stem cell transplantation
Contains fulltext : 225513.pdf (Publisher’s version ) (Open Access)
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… remains largely unstudied in hematopoiesis and hematopoietic stem cells (HSCs). In this thesis, we aim to elucidate the potential cell-autonomous and non-cell-autonomous roles of ARAP3 in hematopoiesis and HSCs using several conditional knockout (CKO) transgenic mouse models in addition to the …
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