Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Hematological malignancies"”.
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Hematology-Oncology Transplant Nurses Experience Through the Moral Labyrinth of Integrating Palliative Care
… improves the quality of life for patients with hematological malignancies, yet the role of hematology-oncology transplant nurses in facilitating this care remains unclear. This study explored the experiences and understandings of 10 hematology-oncology transplant nurses from across Canada, …
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DEVELOPMENT OF 4'-ETHYNYL-2'-DEOXYCYTIDINE (EdC), A REPLICATION-STRESS INDUCING NUCLEOSIDE ANALOG PRODRUG WITH PREFERENTIAL ACTIVITY IN LEUKEMIA AND LYMPHOMA SUBTYPES
… are effective against solid tumors and hematological malignancies, but typically are prone to nucleoside metabolism resistance mechanisms. Using a nucleoside-specific multiplexed high-throughput screening approach, we discovered 4’-ethynyl-2’-deoxycytidine (EdC) as a third-generation …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… be deregulated in many solid tumors as well as hematological malignancies. Such findings have spurred the development of novel therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
… strategy against number of cancers including hematological malignancies and breast cancer. The currently available inhibitors are characterised by a different mechanism and different levels of genotoxicity. Three drugs, (CX-5461, BMH-21 and PMR-116) are small molecules and selective inhibitors …
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
… a Phase I clinical trial of tigecycline in hematological malignancies is underway.
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Machine Learning Techniques for Augmenting Hematological Malignancy Diagnosis
… methods to enhance the diagnostic workflow of hematological malignancies, particularly in cytogenetics and clinical flow cytometry. The recent advancements in the field of ML provide a unique opportunity to develop, adapt, and evaluate algorithms for augmenting the hematopathology diagnostic …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
… and pro-survival functions in human hematological malignancies. Noxa protein is not expressed in unstimulated or naïve human T cells but is induced in CD8+ T cells upon receptor engagement. Activated T cells prepare for rapid proliferation by switching from metabolizing glucose for …
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Patients' experience before, during and after stem cell transplantation-phenomenological study
Patients with refractory hematological malignancies are frequently candidates for life saving but potentially life threatening treatment such as stem cell transplantation (SCT). The purpose of this study was to develop our understanding of the meaning SCT has for African-American, Latino, and …
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Integrin α2 and Akt in early hematopoiesis
… in normal hematopoiesis, but also in various hematological malignancies. However, while the isolation of different cell populations in mouse hematopoietic system is achieved with a very high purity, purification of human hematopoietic stem and progenitor cells still far lags behind. Integrins …
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Isolation and characterization of primitive hematopoietic cells
… such as BM from normal donors and patients with hematological malignancies, or mobilized PB from donors and patients, however, have not been characterized extensively. We therefore sought to characterize SP cells from these human cell sources, analyzed their CD34 expression, CFU-, LTC-IC …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… negative regulation cause erythrocytosis in hematological malignancies. Primary familial and congenital polycythemia (PFCP) is a proliferative disorder characterized by erythrocytosis and hypersensitivity of erythroid progenitors to Epo. Defects in negative regulation of EpoR signaling …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… is currently the only curative treatment for hematological malignancies. Chronic graft-versus-host disease (cGVHD) is a long-term immune complication following aHSCT and a leading cause of non-relapse mortality. The standard of clinical management of broad immunosuppression by corticosteroids …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… roles in several aspects of cell biology. Hematological malignancies have been reported to harbor multiple genes aberrantly silenced by promoter hypermethylation and as a result, cytosine analogs known to inhibit the DNA methylation machinery are currently being evaluated in clinical …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
… tumor cell phagocytosis in both solid tumors and hematological malignancies. These phagocytic innate cells are also professional antigen presenting cells, providing a link from innate to adaptive anti-tumor immunity. Preliminary studies have demonstrated that APCs present antigens from …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
… β2m also serves as prognostic factor for several hematological malignancies, including multiple myeloma (MM). Recent studies demonstrated that β2m actively contributes to MM pathogenesis by aggregating inside the lysosomes of tumor-associated macrophages. The resulting lysosomal damage induces …
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Effects of site specific phosphorylation on the structure and functions of the glucocorticoid receptor
… to restore lost GR function in refractory hematological malignancies. \r\n We show for the first time, that ID AF1 domain of glucocorticoid receptor (GR) adopts a functionally folded conformation due to site-specific (S211) phosphorylation by p38 MAPK that we have earlier shown to be …
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EVALUATION OF THE RISK OF SECONDARY LEUKEMIAS IN CANCER SURVIVORS
… associated with a higher risk of developing hematological malignancies. Moreover, the presence of germline mutations in cancer predisposing genes can increase the risk of t-MNs. Our hypothesis is that chemotherapy can select clones with somatic mutations, leading to secondary neoplasms. We …
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