Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Helminth infection"”.
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Mast cells in gastrointestinal helminth infection
… cell (MMC) in gastrointestinal (GI) nematode infection and the mechanisms that may induce nematode expulsion. We do this using mast cell-deficient (Wsh) mice, as these mice are fertile and not anaemic. Similar to previous studies using W/Wv mice, it is found that Wsh mice are impaired in their …
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Influence of helminth infection on vaginal immunity
Helminth infections induce systemic changes to host immunity and can impact unrelated infections, even those occurring at anatomical sites not normally colonised by the helminths. A few studies have shown that helminths can increase the risk of infection and pathology resulting from sexually …
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The role of pulmonary innate and adaptive immune responses to helminth infection
Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector …
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The role of pulmonary innate and adaptive immune responses to helminth infection
Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector …
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Regulation of HPV infection and cervical cancer development following a helminth infection
Soil-transmi,ed helminth (STH) infec7ons elicit systemic immune responses and have the ability to alter suscep7bility to other infec7ons in sites uncolonized by the STH. Recent work published by our group demonstrated that hookworm infec7on increased pathology in the female genital tract (FGT) …
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The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection
… and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis and S. mansoni infection.
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
The ability of helminths to regulate inflammatory disorders and the mechanisms by which they carry this out are of great scientific interest. Currently, established literature emphasises the protective role of helminth infection in mouse models of inflammatory bowel disease (IBD). Utilising two …
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Does helminth treatment reduce the risk of active tuberculosis in a cohort of children from high tuberculosis risk population who have been vaccinated with BCG at birth?
… between Mycobacterium tuberculosis and helminth infection, with those infected with helminths at greater risk of tuberculosis. This association is believed to be on the basis that chronic helminth infection can result in a functional impairment of the immune response that is necessary to …
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Early-life immunity and susceptibility to Mycobacteria
… immunity. Mycobacterium tuberculosis (Mtb) and helminths are pathogens co-endemic in many LMIC and cause significant morbidity and mortality in children. Infant immune responses to these pathogens, whether during standalone infection, co-infection or resulting from maternal infection are not …
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… interactions after perturbances induced by helminth infection, antibiotics, and non-infectious colitis. We specifically probe the contribution of metabolism by members of the Enterobacteriaceae family of bacteria, a group known to commonly outgrow during intestinal inflammation. In the …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human …
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The role of platelets in the pathogenesis of and immunity to helminth infections
… Little is known on the role of platelets in helminth infections, despite our understanding that many helminth species cause significant vascular pathology as they transfer from the circulatory system to diverse tissues as part of their life cycles. Based on previous studies showing tight …
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Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
… immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to helminth infections may …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
Helminths are known to stimulate regulatory T cells, which have been shown to downregulate inflammatory as well as allergic conditions such as Crohn’s Disease, Ulcerative Colitis and allergic asthma respectively. However, the differences in the Tregs generated during helminth infection compared to …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… is crucial for conferring protective immunity to helminth (Schistosoma mansoni and Nippostrongylus brasiliensis) infection in mice. The role played by cysLTs in the development of protective immune responses to helminth infections is not well documented. Hence in the present study, we investigated …
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Host parasite interaction in a mouse model of inflammatory bowel disease
… compared to the developing world, where infection with intestinal parasites is common.The hygiene hypothesis suggests lack of infection predisposes to the development of IBD ingenetically susceptible people. However, little is known immunologically about how gutparasites alter IBD …
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Gastrointestinal Parasite infections in Chacma Baboons (Papio ursinus) of the Cape Peninsula, South Africa: the influence of individual, group, and anthropogenic factors
… Africa, have affected gastrointestinal parasite infections in a free-living population of chacma baboons (Papio ursinus). Data on parasite diversity and prevalence were obtained from 616 faecal samples collected from over 350 individuals in eight troops (six from the Cape Peninsula, one from …
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
… we investigate the effect of preconception helminth infections on maternal and infant gut microbiota. For maternal antibiotic experiments, dams were fed vancomycin, polymyxin B, or both, in drinking water during gestation, nursing or gestation plus nursing, and their offspring microbiota …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… immune response to promote host control of the infection and also parasite survival in the host. Helminth infections classically induce a potent Th2-biased and regulatory immune imprint. This immune response also influences unrelated inflammatory processes in the host. Studies have shown …
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An investigation of the impact of parasitic worm infection on the immunogenicity of candidate HIV vaccines
… developing worlds such as Sub-Saharan Africa co-infections of HIV and schistosomiasis are common. Helminth infections such as schistosomiasis induce strong Th2 biased immune responses that have been reported to alter HBV, BCG, Tetanus toxoid and some candidate HIV vaccine-specific immune …
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