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Showing 1 to 12 of 12 for “"Helix 1"”.

  1. Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur

    Watzlawik, Jens2012

    … PrPSc-Strukturmodellen wird vermutet, dass die Helix 1 bevorzugt in ein β-Faltblatt bei der Aggregation des Prionproteins umfaltet. Diese Annahme wird durch die NMR-Struktur von nativem PrPC gestützt, da im Kontrast zur isolierten Helix 1, die Helices 2 und 3 nur über einen kurzen Loop …

    goettingen Repository record

  2. The mechanism of conformational change induced by sodium hydroxide in triple helix 1-3-beta-D-glucans.

    Young, Shih-Houng

    uab Repository record

  3. Industry dynamics within semiconductor value chain : IDM, foundry and fabless

    Wu, Shih-Lung, 1963-Massachusetts Institute of Technology2003

    … companies. This analysis will utilize double helix [1] model with consideration of economics of scale, fixed cost and product life cycle. Furthermore, the cost and time-to-market factors involved in SoC (system-on-chip) and FPGA/PLD development will be explored. Based on the analysis, a tool …

    mit Repository record

  4. High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis

    Skora, Lukasz Stanislaw2012

    … sich während der Aggregation des Prionproteins Helix 1 in ein β-Faltblatt umfaltet. Im 3. Kapitel der Arbeit wird unter Verwendung verschiedener Stop-Mutanten des humanen Prionproteins gezeigt, dass keine solche Umfaltung auftritt. Darüber hinaus wird gezeigt, dass obwohl Helix 1 die Aggregation …

    goettingen Repository record

  5. Komplexe des Prion Proteins mit antiprional wirksamen Substanzen

    Mangels, ChristianUniversität Bayreuth

    … Einzelstrangantikörpers W226. Dieser bindet an Helix 1 aus PrPc mit nanomolarer Dissoziationskonstante und kann persistent scrapieinfizierte Zellkulturen heilen. Anhand verschiedener biophysikalischer Methoden, insbesondere Fluoreszenz- und NMR-Spektroskopie, wurden das Epitop und die …

    bayreuth Repository record

  6. Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria

    Guffick, CharlotteUniversity of Cambridge2022

    … spanning synthetic peptides that disrupt helix-helix interactions required for conformational change. Three initial approaches were employed; (i) fragmentation of helices seen as cytotoxic in a preliminary study, (ii) generation of solubility-tagged membrane spanning sequences, and (iii) …

    cambridge Repository record

  7. Mechanotransduction by talin : a molecular dynamics study of force-induced recruitment of vinculin to a focal adhesion complex

    Lee, Seung Eun, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2007

    … in the adhesion, contains the N-terminal five-helix bundle in the rod domain with a known cryptic vinculin binding site 1 (VBS1). The perturbation of this stable structure through elevated temperature or destabilizing mutation activates vinculin binding. Here, molecular dynamics (MD) is …

    mit Repository record

  8. The Structural and Functional Study of GIT1 Paxillin Binding Domain

    Zhang, Ziwei2016

    … (NMR) spectroscopy. The PBD folds into a four-helix bundle, which is structurally similar to the focal adhesion targeting (FAT) domain and the vinculin tail (Vt) domain. The PBD is more stable than the FAT domain and there is no evidence of helix 1 swapping. <br /><br />Previous studies showed …

    tenn-hsc Repository record

  9. Characterization Of Initial Iron Binding Location And The Structure/iron Binding Site On S.cerevisiae Isu And On D.melanogaster Frataxin

    Rodrigues, Andria V.2014

    … majority of the perturbed residues lie on the α helix-1 and β-strands 1 & 2 region; this is in the region of the conserved acidic patch shared by frataxin proteins indicating an iron binding/ chaperone role for Dfh. As the Dfh protein has been found to be much more stable than its yeast and human …

    wayne-thes Repository record

  10. Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches

    Knepp, Adam

    … dimerization involving contacts in transmembrane helix 1 and an amphipathic cytoplasmic helix at the carboxyl-terminal tail of the receptor. This novel interface is postulated to be relevant for understanding GPCR oligomerization in general.</p>

    rockefeller Repository record

  11. Analysis of Molecular Dynamics Simulations of Protein Folding

    Rajan, ArunaUniversity of Illinois at Urbana-Champaign2010

    … transition, corresponding to the flipping of helix 1 relative to the plane formed by helices 2 and 3 was observed towards the end of the folding process in all trajectories, when nearly all native contacts had been formed. However, the transition occurred through a different series of steps in …

    uiuc Repository record

  12. Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations

    Paternoster, CostanzaUniversità degli studi di Trento2025

    … of the transmembrane domain into either an α-helix or a β-sheet, after activation (one then refers to α-PFTs or β-PFTs). This classification reflects not only a structural feature but also distinct biological pathways leading to oligomerization and pore formation; in turn, the study of PFTs …

    trento Repository record