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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 829 for “"Helix"”.
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DNA Recognition by Helix-Loop-Helix Proteins
<p>The Helix-Loop-Helix (HLH) family of eukaryotic transcription factors comprises a large number of proteins which play key roles in homeostasis, the regulation cell proliferation, and differentiation. These proteins share a phylogenetically conserved bipartite b/HLH domain responsible for …
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Structural studies on the basic-helix-loop-helix region from MyoD
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics
… mammals. It consists of three left-handed PPII helixes coiled along a common axis to form a very compact right-handed super helix. The primary structure is shown to be (Gly-Xaa-Yaa)n repeats with high content of prolyl residues at both Xaa and Yaa positions. <i>Cis-trans</i> isomerization of the …
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Bio-inspired swimming helix
This thesis investigated a bio-inspired swimming chain (BISH), inspired by Weelia cylindrica. After developing a model, it was used to investigate conditions under which helical motion would emerge. The properties of this chain as the number of nodes changes was also investigated, to see if the …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… Major players in these events are basic helix-loop-helix (bHLH) genes: Neurogl, Atohl and Neurodl. We investigated whether co-expression of Neurogl and Atohl in common neurosensory precursors could explain the loss of hair cells in Neurogl null mice. Analysis of terminal mitosis, using …
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
… among others. AmrZ, a member of the ribbon-helix-helix family of DNA binding proteins, regulates several virulence factors, including alginate biosynthesis, flagellum expression, and type IV pili localization and twitching motility. AmrZ also acts as an autorepressor by binding two sites on …
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Specificity of triple helix formation
Triplex-forming oligonucleotides (TFOs) have been the subject of extensive<br/>research in recent years. They have potential applications in many areas; such as<br/>gene-based therapies, site-directed mutation and as biochemical tools. However,<br/>triplex technology has been hampered by several …
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Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
<p>Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute …
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High linearity broad-band helix TWTs
Helix travelling-wave tubes (TWTs) are extensively employed as final power amplifiers in satellites. These applications demand low spectral noise and high efficiency across a broad band. Research has been carried out to achieve these criteria in a helix TWT design. A deeper understanding has been …
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Control of Neuroendocrine Cell Physiology by a Single Transcription Factor, Drosophila Basic Helix Loop Helix Regulator DIMMED
… secretory pathway. In this context, the basic helix-loop-helix transcription factor dimmed: dimm) is especially important in the fruit fly Drosophila, but it is not involved in neuroendocrine cell fate determination.</p> <p>Neuroendocrine cells require DIMM to accumulate, and process large …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
… lipids. The lipid-exposed transmembrane alpha-helix, M4, in each homologous subunit likely acts as a lipid sensor. One model proposes that activating lipids promote M4 “binding” to the adjacent alpha-helices, M1 and M3, to enhance interactions between the M4 C-terminus and the Cys-loop of the …
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Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus
ME2 (Tcf4) gehört zu der Familie der basischen Helix-Loop-Helix (bHLH) Transkriptionsfaktoren und aktiviert die Transkription von Zielgenen mittels Bindung an E-Boxen. Die ME2 mRNA-Expression bleibt in adulten zentralen Nervensystem (ZNS) erhalten. Da heterozygote ME2-knockout-Mäuse keinen …
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Optimisation of variable helix end milling tools
… avoidance of milling chatter by using variable helix milling tools. Since milling chatter is strongly influenced by the frequency response function of the dynamic system, a preliminary study is first presented to assess the feasibility of non-contacting electromagnetic modal analysis for milling …
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
… understood. The transcription factor Nescient Helix Loop Helix 2 (Nhlh2), is known to influence the melanocortin pathway. It regulates the transcription of genes by binding to the E-Box binding sites present in the promoter region. Here in this dissertation, Nhlh2's role as a transcriptional …
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Part 1 Synthesis of a potent histone deacetylase inhibitor; Part 2 Studies towards a stabilized helix-turn-helix peptide
… structure mimics and incorporate them into the helix-turn-helix (HTH) motif. One of the important methods to study the conformation of the biologically active peptides is to incorporate the rigid peptidomimetics into the relevant peptides. Important information can be obtained from the study of …
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Biochemische Charakterisierung der basischen Helix-Loop-Helix-Transkriptionsfaktoren Hey1 und Hey2 sowie Untersuchung ihrer Rolle während der Herz- und Gefäßentwicklung
… drei hairy/E(spl)/Hes-verwandte basische Helix-Loop-Helix-Transkriptionsfaktoren, die durch eine Orange-Domäne und einen charakteristischen Carboxyterminus gekennzeichnet sind. Während der Embryonalentwicklung werden die Hey-Gene dynamisch in zahlreichen Geweben exprimiert. Ziel dieser …
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Charakterisierung des HELIX-128-Auslesechips für HERA-b
… beschreibt die Charakterisierung des CMOS-Chips HELIX 128. Der HELIX 128 wurde im ASIC-Labor Heidelberg entwickelt und wird als Auslesechip für den Vertexdetektor und die Mikrostreifengaskammern des inneren Spurkammersystems am Experiment HERA-B eingesetzt werden. Er besteht aus 128 …
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A Monte Carlo Study of the Helix-Coil Transition
Made available in DSpace on 2014-12-09T17:35:35Z (GMT). No. of bitstreams: 1 6612404.pdf: 2787704 bytes, checksum: 175cf198fb0837cbb1b50a637a8f3253 (MD5) Previous issue date: 1966
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Energetics of [alpha]-helix formation in peptides and proteins
This thesis focuses on the energetics of !-helix formation in peptides and proteins. The [alpha]-helix is the most prevalent type of secondary structure found in proteins, and has arguably dominated our thinking about protein structure since its discovery, as it plays an important role in the early …
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Calculation of effective electromagnetic parameters of helix loaded composites
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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