Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Heligmosomoides polygyrus"”.
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
… to better understand worm-host interactions. H. polygyrus larvae induce an intestinal granuloma response whereby immune cells, mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites. In vitro, these cells and antibodies immobilize, damage/kill …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
… infection with the gastrointestinal nematode Heligmosomoides polygyrus does not result in increased CD4+CD25+-mediated suppressive activity. Using two different infection protocols, we characterized the CD4+CD25+ Treg-mediated response to acute and chronic infection from two different gut …
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
… gender. Using the gastrointestinal helminth Heligmosomoides polygyrus (H.polygyrus), I demonstrate that helminth infection exacerbates IBD in both the oxazolone and DSS models of colitis. Underlying helminth infection results in increased inflammation locally in the colon and systemically in …
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Heligmosomoides polygyrus-induced serum factors limit respiratory syncytial virus titres: a potential role for CCL8
Heligmosomoides polygyrus (H. polygyrus) is a naturally occurring intestinal nematode that employs immunomodulatory mechanisms towards the establishment of long term chronic infections within mice. The robust host Type 2 immune response to H. polygyrus infection can lead to a subdual of excess …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
… (LPMs), during coinfection with a parasite, Heligmosomoides polygyrus (HP). We found that coinfection with HP increases the number of MHV68-infected LPMs during acute replication and latency. Further, coinfected mice had increased ex vivo reactivation of MHV68. By using dietary and genetic …
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Cancer cell behaviour following parasite exposure
… to antigen from the gastrointestinal nematode Heligmosomoides polygyrus decreased the in vitro proliferation of human and mouse colorectal cancer cells and simultaneously increased the expression of cell cycle regulator proteins, p53 and p21. Surprisingly, while antigen from H. polygyrus …
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Regulation of HPV infection and cervical cancer development following a helminth infection
… an7gens from Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri decreased HPV PsV infec7on in two cervical cancer cell lines and one primary kera7nocyte cell line (the target cell of HPV). Similarly, exposure to the excretory-secretory (ES) an7gens from H. polygyrus decreased HPV …
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Immune gene expression and diversity in relation to gastrointestinal parasite burden in small mammals
… association between the parasitic nematode Heligmosomoides polygyrus and hepatic MHC mRNA levels. As a lower MHC expression entails a lower immune response, this could be evidence for an immune evasive strategy of the nematode, as it has been suggested for many micro-parasites. This implies …