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Showing 1 to 20 of 293 for “"Helices"”.
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The Scripture of Helices
<p>This thesis comprises poems written during my two years of study for the Master of Arts Degree in English with a creative writing emphasis. The majority of the poems are written in either a received or contemporary form, although a substantial minority are written in free verse. Many of the …
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A Study of Wave Propagation on Helices
Made available in DSpace on 2015-05-12T17:06:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 6402914.PDF: 3822574 bytes, checksum: 8944c8d8ecd3f6d6bd053ef405082576 (MD5) Previous issue date: 1963
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Biophysics of Helices: Devices, Bacteria and Viruses
A prevalent morphology in the microscopic world of artificial microswimmers, bacteria and viruses is that of a helix. The intriguingly different physics at play at the small scale level make it necessary for bacteria to employ swimming strategies different from our everyday experience, such as the …
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Novel nucleotide analogues for forming stable DNA triple helices
DNA triple helices are an important tool in a variety of medicinal and biotechnological applications, such as gene therapy and chemotherapeutics. DNA triple helices are formed by binding of a triplex-forming oligonucleotide (TFO) to a DNA duplex, via specific recognition of the individual base …
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Experimental characterization of polyalanine helices in short and long contexts
Three principal analytical methods: circular dichroism (CD), hydrogen exchange, and the t/c ratio of Ac-Hel, a helix stabilizing N-cap, are used in combination to quantify fractional helicity in order to determine the intrinsic helical propensity of an alanine residue, free from the hydrophobic …
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Identificaiton of the pore-lining helices of connexin 43 gap-junctional hemichannels
… connexins, proteins that have four transmembrane helices. The transmembrane helices that line the gap-junctional pore have not been identified, and their identification was the main goal of my dissertation project. To accomplish this goal, I used a combination of molecular biology, biochemical and …
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Synthesis of beta-lactones, II. Use of templated helices to determine Zimm-Bragg parameters
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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I. Macromolecular and architectural effects on the polymerization of α-helices & II. Functional ROMP curing polyester thermosets
… the folding of the polymers into alpha-helices was shown to drastically increase the rate of propagation. Furthermore, when the alpha-helices were organized in a close, parallel array along a separate polymer scaffold, the polymerization was found to increase in rate even more …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… the relative position of two transmembrane helices, six and twelve (TM6 & 12), by measuring the distances between residues. Site directed mutagenesis was used to generate nine double mutants, each containing one cysteine on TM6 and one on TM12. Double mutants were expressed using the …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… the relative position of two transmembrane helices, six and twelve (TM6 & 12), by measuring the distances between residues. Site directed mutagenesis was used to generate nine double mutants, each containing one cysteine on TM6 and one on TM12. Double mutants were expressed using the …
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Modeling the flexibility of alpha helices in protein interfaces : structure based design and prediction of helix-mediated protein-protein interactions
… important sub-space of protein structure: alpha helices that participate in protein interfaces. Helices, the global structural properties of which can be described with only a few variables, are particularly well suited for efficient sampling. Two methods for sampling helical backbones are …
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Development of Specific and Potent α-Helical Inhibitors and Probes of Cysteine Proteases
… We developed a new method for stabilizing α-helices using natural amino acids that allowed us to make small peptides into α-helical inhibitors. We were then able to use structure based design to turn these α-helices into specific inhibitors and probes for use in understanding the proteases' …
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Multifilar Hemispherical Helical Antennas
Helices are broadband antennas that provide moderate gain, largely real input impedance and circular polarization when operating in the axial mode regime. A modified form of the helix, the spherical helix, has been shown to yield similar polarization and gain characteristics over a narrow bandwidth …
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Investigation of the phase transitions of pregelatinized waxy maize starch at low moisture contents
… as the reorganization of amylopectin into double helices following gelatinization, but without the aggregation of the double helices into crystalline arrays that can occur during the full retrogradation process. The reorganization into double helices, and hence the development of the sub-Tg …
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Studies of Protein Folding on Membranes and in Crowded Environments and Bridging the Research-Teaching Gap in K-12 Science
… algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization of membrane binding of single surface and trans-membrane helices. I then describe the effects of excluded volume on the stability and kinetics of a stable Lambda Repressor mutant …
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Studies of protein folding on membranes and in crowded environments and bridging the research-teaching gap in K-12 science
… algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization of membrane binding of single surface and trans-membrane helices. I then describe the effects of excluded volume on the stability and kinetics of a stable Lambda Repressor mutant …
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Insights into the Energetics of Membrane-Bound Peptides : Towards an Understanding of the Structural Organisation of Membrane Proteins
… to screen the helix dipole of membrane-bound helices depending on the proximity and geometry of the aqueous phase relative to the helix termini. As a result, the helix dipole of transmembrane helices is found to decrease with peptide length. The analysis is extended to helices in soluble …
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Self-assembly of helical ribbons from chiral amphiphiles
… ribbons were right-handed; but some left-handed helices have been found. Additionally, a small number of helices with pitch angles between 30 and 47ʻ were found in some systems. The elastic properties of the low pitch helical ribbons in Chemically Defined Lipid Concentrate were studied via …
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Geometric and elastic properties and mechanical phase separation phenomena in self-assembling mesoscopic helical springs
… Defined Lipid Concentrate (CDLC) system. These helices typically have radii on the order of a few to a few tens of microns and lengths on the order of hundreds of microns. By tethering to these mesoscopic helical ribbons using Devcon 5-Minute Epoxy®, we have been able to elastically deform them, …
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