Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Hedgehog signalling"”.
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Hedgehog signalling in CD8+ T cell memory
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Astrocytic Sonic Hedgehog signalling in development and disease
Sonic hedgehog (Shh) signalling is a critical pathway in embryonic development, with known roles in cell differentiation, tissue patterning, and the establishment of body axes (Rowitch et al., 1999; Echelard et al., 1993; Ericson et al., 1997; Jessel and Lumsden, 1997). Beyond these canonical …
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The role of Hedgehog signalling in T cell effector function
… of challenges such as infection and cancer. The Hedgehog (Hh) signalling pathway has long been known to play a critical role in embryonic development and adult tissue maintenance. Recently, Hh signalling has been shown to be important for CD8+ T cell function downstream of T cell receptor (TCR) …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
<p>The Hedgehog (Hh) signal transduction pathway functions as one of the key developmental pathways and deranged Hh signalling is associated with numerous cancer and tumor conditions. The Smoothened (Smo) G protein coupled receptor (GPCR) functions as the signal transducer of the Hh pathway and is …
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Hedgehog - like Proteins are Involved in a Novel Glia - Neuron Signalling Pathway in C. elegans
… of inquiry that led me to a novel glia-neuron signalling pathway that regulates neuronal properties in very specific ways. Two key players in this mechanism are WRT-6, a Hedgehog-like protein secreted by the socket glia, and PTC-1, a Patched homolog found in the amphid neurons. It is believed …
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Identifying targets of the MAST kinase Drop out through genetic and proteomic analysis in Drosophila melanogaster
… Dop is identified as a regulator of the Hedgehog signalling pathway, and is required in signal transduction.
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Genomic Regulation of the Shox2 Gene during Mouse Limb Development
… and with the Shox2 gene, suggesting that hedgehog signalling may be a regulatory input for this gene’s expression. Genetic examination of composite Shox2/Gli3 and Shox2/Shh mutations show Shox2 to cooperate with Gli3 and Shh to pattern the stylopod.
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Stromal interactions in pleural mesothelioma
… to sarcomatoid PM that upregulate genes in Hedgehog signalling pathways. This work advances our understanding of how PM may evolve across histological subtypes and highlights signalling pathways that could be targeted for future therapeutic benefit.
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… coordinated intercellular communication via signalling pathways, mechanisms underlying intestinal morphogenesis remain unclear. The Hedgehog signalling pathway is critical for many aspects of gut development, however, its downstream transcriptional targets allowing for complex cell behaviours …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… are also regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the ventral telencephalon (vTel), through diffusion to form a concentration gradient. Strikingly, when Pax6 is deleted, a subset of cortical progenitor cells that would normally become glutamatergic …
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Notch signalling in spinal cord patterning: Crosstalk and fate decisions
… particular focus on the highly conserved Notch signalling pathway. The major, and most well studied, role of Notch signalling during neural development is progenitor maintenance. This thesis explores the additional roles of Notch signalling in signalling crosstalk and cell fate decisions. The …
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Stiffness controls primary cilia position and length: mechanisms and potential in reversing osteoarthritis phenotypes
… its length and position to fine-tune cell mechanosignalling based on substrate stiffness alone. A polyacrylamide hydrogel system of varying substrate stiffness was used to examine the role of substrate stiffness on cilia frequency, length and centriole position as well as cell and nuclei area over …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
Hedgehog (Hh) signalling is a classical morphogen pathway that regulates key processes in embryonic development, adult tissue homeostasis, and tumorigenesis. Recently, the Hh pathway has also been shown to be critical for CD8+ and CD4+ effector functions, acting in a cell-autonomous manner and …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… understood. Recent research has implicated the Hedgehog pathway transcription factor, Gli1, in the development of fibrosis in numerous organs. This study aims to characterise Gli1 expression in ocular tissues and to elucidate the role of Gli1 in the development of fibrovascular membranes in the …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR stimulation and has been shown to be important in CTL cytotoxic ability through its role in the …