Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Hedgehog signaling"”.
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Studies of Smoothened in Hedgehog Signaling Pathway
The Hedgehog (Hh) family of morphogens controls cell growth and patterning in both vertebrates and invertebrates. Malfunction of Hh signaling has been implicated in numerous human disorders. As the Hh signal transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… first time the expression and the role of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… cartilage, and subchondral bone changes. Hedgehog (Hh) signaling is known to be activated in human and murine OA. Since Hh signaling regulates Gli-mediated gene expression, we identified Hh target genes that are expressed in chondrocytes. Microarray analyses were performed to detect …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
The involvement of hedgehog (Hh) signaling in cell determination and differentiation in a wide variety of tissues in both invertebrates and vertebrate has been well established. However, relative little is known about its function in formation of adipose tissues. To address this question, …
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Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… (A549-M cells) led to the up-regulation of sonic hedgehog (Shh) both at the mRNA and protein levels causing activation of hedgehog signaling. These results were also reproduced in another NSCLC cell line (H2030), and these results were further associated with the induction of EMT phenotype. …
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
… on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show that the gpi-linked heparan sulfate proteoglycan Dally is released …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… the tumor microenvironment (TME).</p><p>The hedgehog (Hh) signaling pathway is one of the most important signaling pathways in cancer. Its aberrant activation within cancer cells can lead to increased proliferation and metastasis. Hh ligands, including sonic hedgehog (Shh), desert hedgehog …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… in granule cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that the proliferation defect of granule cells is associated with SHH - N-Myc pathway impairment in the …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
… both require the formation of new cells and signaling pathways to control their specification and function. The Hedgehog signaling pathway has been implicated in anterior-posterior polarity specification, but no role in planarian nervous system regeneration has been described despite that …
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The Role of Sonic Hedgehog in Outflow Tract Development
… its development is regulated by many different signaling pathways. One of these pathways is the Sonic hedgehog pathway. This thesis tests the hypothesis that Sonic hedgehog induces secondary heart field proliferation, which is necessary for normal outflow tract development. To address this …
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Signaling crosstalk in cancers
Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation …
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Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… axolotl spinal cord. Furthermore, the secreted signaling molecule sonic hedgehog (Shh) is expressed in the floor plate in both the differentiated and the regenerating cord. Using a chemical inhibitor (cyclopamine) and an activator of the hedgehog pathway, I discovered that hedgehog signaling is …
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Mechanisms of axial polarity modification during postembryonic development of the basal bilaterian Convolutriloba macropyga
… modification and reversal are not known. Wnt, Hedgehog, and other signal transduction pathways have conserved roles in AP axis development and reestablishment during both metazoan embryogenesis and regeneration, suggesting these signals may function in mediating changes in axis polarity during …
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MOLECULAR CHARACTERIZATION OF THE PUTATIVE NUCLEOTIDE- BINDING AND HYDROLYZING ACTIVITIES OF THE ELLIS VAN CREVELD (EVC) PROTEIN
… positively regulates the Sonic and Indian hedgehog signaling pathways by promoting downstream processes after activation of the smoothened receptor (Smo), by the hedgehog proteins. Bioinformatic analysis revealed the presence of several structural motifs in EVC sequences including P-loop, …
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A multi-dimensional microfluidic platform recapitulating chemotactic and morphogenic chemical gradients
… tool, we were able to probe the role of Wnt signaling during Sonic Hedgehog based patterning of the vertebrate ventral neural tube. Using the presumptive enhancer for the p3 progenitor domain gene Nkx2.2, our findings indicate that such an enhancer would both negatively and positively …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… our current understanding of adipose biology. Hedgehog signals regulate invertebrate and vertebrate development, yet the role of the cascade in adipose development was undefined. I found that fat body specific transgenic activation of Hedgehog signaling inhibited fly fat formation. Conversely, …
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Regeneration and maintenance of the planarian nervous system
… distribution. The function of the planarian hedgehog gene in the patterning of CNS regions was investigated. hedgehog was expressed in the medial planarian brain, flanked by nkx2 and nkx6, then pax6b, and finally dlx-1 and msx at the most distal positions. This organization is similar to the …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… signature with the activation of Wnt and Hedgehog signaling pathways, which were well known key features of BCC. By contrast, the SCC-like BCC was enriched with immune-response genes and oxidative stress-related genes. Network analysis revealed the PLAU/PLAUR as a key regulator of SCC-like …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… birth, in response to paracrine signals Desert hedgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells. Ovaries lacking Dhh/Ihh exhibited a loss of theca layer, blunted steroid production, arrested folliculogenesis, and failure to form corpora lutea. Production of Dhh/Ihh in granulosa …
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Brain regeneration in a hypoxic-ischemic mouse model
… neural stem cells which are regulated by sonic hedgehog signaling were also significantly increased in neurogenic niche following HI insult. At last, many numbers of neural stem cell was observed in injured cortex and differentiated to neuronal and glial cells in late phage. This recovery …
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