Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hedgehog Proteins"”.
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Desert Hedgehog is a Mammal-Specific Gene Expressed During Testicular and Ovarian Development in a Marsupial
<h1>Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH …
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MOLECULAR CHARACTERIZATION OF THE PUTATIVE NUCLEOTIDE- BINDING AND HYDROLYZING ACTIVITIES OF THE ELLIS VAN CREVELD (EVC) PROTEIN
… positively regulates the Sonic and Indian hedgehog signaling pathways by promoting downstream processes after activation of the smoothened receptor (Smo), by the hedgehog proteins. Bioinformatic analysis revealed the presence of several structural motifs in EVC sequences including P-loop, …
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Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
The widespread and indispensable nature of Wnt morphogens during early development has long been a focal point of embryogenesis research. More recently, pathway activation has been uncovered in adult stem cell niches and cancers arising from associated tissues. Consequently, interest has shifted …
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Studies of Smoothened in Hedgehog Signaling Pathway
The Hedgehog (Hh) family of morphogens controls cell growth and patterning in both vertebrates and invertebrates. Malfunction of Hh signaling has been implicated in numerous human disorders. As the Hh signal transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… our current understanding of adipose biology. Hedgehog signals regulate invertebrate and vertebrate development, yet the role of the cascade in adipose development was undefined. I found that fat body specific transgenic activation of Hedgehog signaling inhibited fly fat formation. Conversely, …
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Chemically Based Interrogation of Smoothened, a Proto-Oncogenic Component of the Hedgehog Signal Transduction Pathway
Aberrant activation of the Hedgehog (Hh) signal transduction pathway is crucial for the initiation and maintenance of many cancer types. Underlying this deviant signaling process in most cases of cancer is genetic mutations that give rise to misactivation of the seven transmembrane oncoprotein, …