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Showing 1 to 13 of 13 for “"Heck coupling"”.
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Palladium-Imidazolium Carbene Catalyzed Heck Coupling Reactions and Synthesis of a Novel Class of Fluoroanthracenylmethyl PTC Catalysts
<p>Palladium catalyzed Heck coupling with aryl and alkenyl halides has become a powerful means of carbon-carbon bond formation. This standard synthetic method has been developed to a high level of utility using various catalysts, conditions and substrates. Yet significant drawbacks remain, …
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Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies
… vivo evaluation.</p><p> More importantly, a new Heck coupling of the thiophene iodide 301 and allyl alcohols to synthesize aldehydes in one step was discovered. Due to its potential use in analog synthesis of clinically used antifolates such as RTX and PMX, this mild conditioned and easy to …
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Metallodendrimers as catalysts for C-C coupling reactions
… the complexes were screened for activity towards Heck coupling model reaction of iodobenzene with styrene. The complexes catalyzed the coupling of styrene with iodobenzene, giving over 60 % conversions. However, complex C3 was found to be the most active catalyst, yielding 75% conversion without …
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Intramolecular Heck couplings of unactivated alkyl electrophiles : synthetic and mechanistic studies
… for the palladium-catalyzed intramolecular Heck coupling of unactivated alkyl bromides and chlorides is described. The optimal catalyst system was composed of Pd2(MeO-dba)3 as the metal source and N-heterocyclic carbene SIMes as the ligand, and the influence of both parameters is discussed. …
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Engineering polymeric hollow fiber membrane reactors for sustainable chemical transformation reactions
… including aldol and nitroaldol condensation, Heck coupling, tandem reaction of glucose and fructose to 5-hydroxymethylfurfural, and nitrophenol reduction reactions”--Abstract, page iv.
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Catalytic enantioselective synthesis of oxindoles and benzofuranones bearing a quaternary stereocenter and reactions of palladium bisphosphine complexes relevant to catalytic C-C bond formation
… and Pd(P(t-Bu₂)Et)₂ for the cross-coupling of alkyl electrophiles. The reductive elimination of H-X from bisphosphine palladium-hydride complexes is also discussed. The discovery that (P(t-Bu)₃)₂PdHCl undergoes facile reductive elimination in the presence of Cy₂NMe, while …
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Renewable imidazolium zwitterions as platform molecules for the synthesis of ionic liquids and materials
… for the dissolution of cellulose and the Heck coupling.
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Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… PR2NRʹ2 complexes were assessed for the Heck coupling of phenyltriflate and styrene, which showed regioselective formation of linear or branched product formation based on the phosphorus R substituent. Investigations into the factors controlling the regioselective product formation were …
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Total Syntheses of 1,2,4-Thiadiazole Natural Products
… and 24b focused on a late-stage intermolecular Heck coupling of 5-chloro-1,2,4-thiadiazole 217 with spiro-5',6'-dihydrothiopyran (±)-280 to forge the heterocyclic framework of the natural products (±)-289. Ultimately, this strategy was unsuccessful since the desired 5',6'-dihydrothiopyran …
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Organic Synthesis: Taming Chemistry using Enabling Technologies
… These gas-lquid reactions were an ethylene Heck coupling reaction, an anti-Markovnikov Wacker oxidation and a rhodium-catalysed stereoselective hydrogenation respectively. In addition, a diastereoselective Reformatsky-type carbethoxyallylation using zinc metal was also highlighted in this …
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Studies Towards the Total Synthesis of Patellazole B
… union and formation of the macrocycle. A Heck coupling reaction has been employed to construct the C19-C20 bond and a Suzuki coupling reaction has been developed to facilitate the C12-C13 bond formation. These two cross couplings have delivered the C1 - C25 fragment, 360, the final …
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Repurposing quinoline-based (metallo) drug leads for the treatment of Leishmania major-induced cutaneous leishmaniasis
… azide-alkyne cycloaddition and Mizoroki-Heck coupling. All the compounds were fully characterised using standard spectroscopic (1H,13C{1H} NMR and FT-IR spectroscopy) and analytical (mass spectrometry, melting point and elemental analysis) techniques. The four compounds and their …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
Pyranonaphthoquinone lactones have been recently found to be selective inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of …