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Showing 1 to 20 of 43 for “"Heat shock response"”.
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Are thermotolerance and heat acclimation related through the heat shock response?
… that allow survival after an acute, severe heat exposure) and heat acclimation (systemic adaptations that improve heat dissipation following chronic heat exposure) have traditionally been considered separate phenomena. However, recent studies in animals suggest these adaptations may be …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
… with the environment to achieve homeostasis. The heat shock response (HSR) is one of the most well studied fundamental cellular responses to environmental and physiological challenges, resulting in rapid synthesis of heat shock proteins (HSPs), which serve to protect cellular constituents from the …
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Coordination Between Autophagy and the Heat Shock Response: Evidence From Exercise in Animals and Humans
… protein quality is managed in part by the heat shock response, which acts to support, isolate, and reform new or damaged proteins, and in part by the autophagic recycling of abnormal proteins, cytotoxic protein aggregates, and terminally damaged organelles. We conducted a pooled analysis of …
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The heat shock response in embryonic and young of the year juvenile round whitefish (prosopium cylindraceum)
… post hatch by characterizing the kinetics of the heat shock response (HSR). The HSR provides protection from a variety of stressors (i.e., thermal stress) at the cellular level and is characterized by the upregulation of a suite of proteins called heat shock proteins (Hsps). Round whitefish …
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Deciphering Functional Significance of Substrate-Binding Domain of Ssa1 on Heat-Shock Response and Prion Propagation
The Hsp70 (70kDa heat shock protein) is highly conserved in all species and has been implicated in a variety of important cellular functions such as heat shock response, prion propagation, protein folding and refolding, translocation across membranes and assembly of macromolecular complexes. A …
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The impact of acute heat exposure on the heat shock response (HSR) between males and females
While acute heat stress induces genomic changes in immune cells of young adults, the influence of ovarian hormones on the molecular response remains unclear, despite their documented role in thermoregulation. This study investigated the molecular response to acute heat stress in males (n=11), …
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The heat-shock response in <i>Serpula s</i>pecies at the cellular and molecular level
The study focuses on the effects of heat stress on <i>Serpula lacrymans</i> and <i>S. himantioides</i> (which have been previously shown to be relatively thermosensitive and thermotolerant respectively) in relation to the heat shock response. A part of this response is the production of heat-shock …
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The role of cytostructure in the control of protein synthesis and the prompt heat shock response
Bibliography: v.2, leaves 286-318.
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Plasticity of the heat shock response and development of thermotolerance during embryonic development of Lake Whitefish (Coregonus clupeaformis)
… between how temperature and frequency of heat shock and post-heat shock recovery time can modulate the heat shock response to a subsequent more severe stressor; 2) determine if this interplay is the same at different embryonic stages; and 3) assess whether transient heat shocks confer …
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Assessing The Therapeutic Viability of Hsc70 in ALS
… neurons. When cells face stressful insult the heat shock response is activated in an attempt to reduce intracellular calamity. The heat shock response is identified by the increased expression of heat shock proteins (HSPs), which act as part of a chaperone network within the cell to combat an …
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The Pursuit of Unshocking Hsp90 Inhibitors: Development of Gedunin and Cruentaren A as Chemical Leads
Abstract: The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that is critical cellular survival and growth under both typical and stressful conditions. Hsp90 is responsible for the maturation and stability of more than 200 client proteins involved in a diverse assortment of cellular …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… of several genes, termed vitagenes. Among these, heat shock proteins, also known as stress proteins and molecular chaperones, are highly conserved proteins for the preservation and repair of the correct conformation of cellular macromolecules, such as proteins, RNAs and DNA. Chaperone-buffered …
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Inducción térmica del inicio de la replicación cromosómica en Escherichia coli
… of extra rounds of chromosome replication. This heat-induced replication (HIR) initiates at oriC, is transitory, requires RNase H1 and RecA and requires neither RNA polymerase activity nor de novo protein synthesis. HIR is neither related to SDR nor induced by the heat shock response. A …
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Redox Sensing By Yeast Hsp70 Facilitates Modulation of Protein Quality Control and The Cytoprotective Response
… the major transcription factor controlling the heat shock response, and the oxidomimetic Ssa1 failed to stably interact with Hsf1, resulting in constitutive activation of the heat shock response. Consistent with the in vitro findings, <em>ssa1-2CD </em>cells were compromised for <em>de novo …
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Investigating the role of eEF1A2 in motor neuron degeneration
… the individual roles of eEF1A1 and eEF1A2 in the heat shock response. I used RNAi to ablate each variant separately in cells and subsequently measured the ability of each variant individually to mount a heat shock response. Results indicate a clear role for eEF1A1 but not eEF1A2 in the induction …
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Stress response of porphyromonas gingivalis
The heat shock response of Porphyromonas gingivalis was examined by one-and two-dimensional polyacrylamide gel electrophoresis after metabolic labeling with (14C)-amino acids. When P. gingivalis cells were shifted from 37°C to 42°C, elevated synthesis of four proteins with the apparent molecular …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
<p>The mechanisms underlying cellular response to proteasome inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
… proteins such as α-synuclein. Induction of heat-shock proteins (HSPs), such as through activated heat shock transcription factor 1 (HSF1) via Hsp90 inhibition, is being investigated as a therapeutic option for proteinopathic diseases. HSF1 is a master stress-protective transcription factor …
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Antioxidents or reduced oxygen tension as a defense system in T cells ex vivo and in vitro
… physiology example: reduced DNA repair capacity, heat shock response and an accumulation of biomolecule damage may have contributed to these findings.
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