Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Heat shock factor 1"”.
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Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
… folding and clearance in these disorders. Heat shock proteins (HSPs), such as HSP70 and HSP90 are molecular chaperones that maintain protein homeostasis and prevent neuronal death. HSPs are regulated by a stress-induced transcriptional factor, heat shock factor 1 (HSF1). HSF1 is inactive …
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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis
… to address this aspect via focus- ing on the Heat Shock Factor 1 (HSF1)-dependent mechanisms. We found that Riluzole could increase HSF1 and BDNF (Brain-Derived Neurotrophic Factor) expression both at transcriptional and translational levels. CA1 (Cornu Ammonia, the first region in the hip- …
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Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… fitness is promoted by the transcription factor heat shock factor 1 (HSF1) during exposure to proteotoxic stress. HSF1 controls the basal and stress-induced expression of molecular chaperones and other protective targets. Dynamic regulation of HSF1 involves the major heat shock proteins …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… the illness, but rather as symptomatic therapy. Heat Shock Protein (HSP90), is one of the molecular chaperones that plays a role in AD pathogenesis. HSP90’s main function is to regulate the heat shock factor-1 (HSF-1) transcription factor, which is the key regulator of the heat shock response. …
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Controlled Myogenic Differentiation of Mammalian Cell Lines by Temperature-Inducible Systems
… promoter (HSP70) carrying multiple heat shock elements (HSE), whose activity can be modulated by changes in temperature, enabling precise control of the expression of an exogenous master gene of myogenesis (MyoD) and a chromatin modifier (SMARCD3). To establish the optimal …
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… that form the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) complex. The proteins in this complex reside on the vesicle membrane (synaptotagmin 1 and synaptobrevin/vesicle-associated membrane protein, which is also known as VAMP) and the plasma membrane (syntaxin …
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Leveraging HSF1 chemical-genetic tools to elucidate mechanisms of proteostasis
… extensive network of chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network. This network assists folding and maintains optimal protein localization and concentration. While the components and organization of this network are generally …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… SMCs. This retention activates heat shock factor 1, which drives endogenous cholesterol synthesis through increased HMG CoA reductase levels, leading to increased cellular cholesterol, ER stress, and PERK signaling in <em>Acta2<sup>R149C/+</sup></em> SMCs. Consequently,<em> …
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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease
… by synaptic dysfunction. Strategies targeting heat shock protein 90 (Hsp90) inhibition have been widely investigated in the treatment of cancer for over two decades. Its application in the treatment of neurodegenerative diseases however, has emerged more recently in the last decade. The role of …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… Uncontrolled hyperglycaemia and genetic factors are implicated in the pathogenesis of diabetic microvascular diseases. Genetic mutation through the genes coding for enzymes involved in glucose metabolism and immuno-regulatory mechanisms may contribute to the susceptibility to type I …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
… proteins such as α-synuclein. Induction of heat-shock proteins (HSPs), such as through activated heat shock transcription factor 1 (HSF1) via Hsp90 inhibition, is being investigated as a therapeutic option for proteinopathic diseases. HSF1 is a master stress-protective transcription factor …
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Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease
… This transition is dependent on Kruppel-like factor 4 (Klf4).<strong> </strong>We previously demonstrated that SMCs treated with free cholesterol complexed to methyl-β-cyclodextrin (MBD-Chol) <em>in vitro</em> induces endoplasmic reticulum (ER) stress and activates the unfolded protein …
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… permeability through up-regulation of the heat shock response resulting in occludin stabilization, and (2) depresses the exercise induced inflammatory response. Methods. Eight human subjects (n=8) participated in baseline (PRE) testing, a glutamine (GLN), and placebo (PLA) supplementation …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
… Under basal conditions, transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) is targeted for ubiquitination and proteasomal degradation by a repressor protein Kelch-like (ECH)-associated protein (KEAP1), a substrate adaptor for Cullin 3-based E3 ubiquitin ligase. …
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Targeting mutant p53 in cSCCs
… UV-radiation as one of the main risk factors for cSCC development. Mutant p53 proteins can lose wt-p53 functions, have dominant-negative effects against wt-p53 and acquire gain of function (GOF) activities. Mutant p53 GOF activity is induced by the accumulation of mutant p53 in tumour …