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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Heat Shock Protein 70"”.
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Kinetics study of heat shock protein 70 expression
Heat shock protein 70 (HSP70) is well known for its efficacy in cardiac ischemia protection. The purpose of this study was to determine HSP70 expression kinetics in response to mild thermal stress. Currently there are no comprehensive experimental HSP70 expression kinetics data available. An …
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Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction
Tumor and cancer cells that over express heat shock protein 70: HSP70) are found to be multidrug resistant and thermo tolerant, creating a hurdle to existing therapy. Although HSP70 is recognized as an increasingly important drug target, the protein structure of this highly conserved chaperone …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
… contributes to increased apoptotic activity. Heat shock protein 70 (Hsp70) is a stress-induced protein and this protein can be a specific marker for this ischemic and apoptotic circumstance, preeclampsia. Therefore we compared immunohistochemical expression of Hsp70 in normotensive and …
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Defining a Role for Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo
… offer limited efficacy. Observations that heat shock proteins (HSPs) can serve as adjuvants in antitumor vaccines first suggested to us a link between HSPs and stress-induced vitiligo. Such proteins are marvelously well conserved throughout evolution, which has placed them in the spotlight …
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Role of heat shock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system
Intrazelluläres Hitzeschockprotein 70 (HSP70) gehört zum zellulären Stress-Antwort-System und kann Zellen vor unterschiedlichen apoptotischen Stimuli schützen. Extrazelluläres HSP70 hingegen kann Zellen des angeborenen und erworbenen Immunsystems aktivieren. Die akute Überexpression von …
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The Effect of Hyperthermic Whole Body Heat Stimulus (Sauna) on Heat Shock Protein 70 and Skeletal Muscle Hypertrophy in Young Males during Weight Training
… aid skeletal muscle hypertrophy by stimulating Heat Shock Protein 70 (HSP70), which acts as a molecular chaperone to the folding of functional skeletal muscle. The aim of this study was to investigate if stimulating HSP70 by using a sauna (45 – 50 ͦC, 80% Humidity) three times per week, for 15 …
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Treatment of Aortic Heart Valve Conduit with Glutamine and Heat Shock as a Means to Deter the Constituent Cellular Population From Becoming Apoptotic
… Recently it has been demonstrated that: 1) Heat shock protein 70 is a negative modulator of the apoptotic cascade; 2) Cells in culture exposed to hypothermic conditions produce heat shock protein 70 upon rewarming; and 3) Glutamine can induce heat shock protein 70 production. The purpose of …
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Polymorphisms in heat shock protein receptors
Das extrazelluläre Hitzeschockprotein 70 (Heat Shock Protein 70, HSP70) kann als immunologisches Gefahrensignal fungieren und stimuliert die Aktivität zytotoxischer T-Lymphozyten und natürlicher Killerzellen. In diesem Kontext stellt HSP70 ein vielversprechendes Werkzeug im Rahmen immunologischer …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
… to proteasome inhibition is repression of global protein synthesis by phosphorylation of the eukaryotic initiation factor 2-α subunit (eIF2α). In a panel of 10 distinct human pancreatic cancer cells, we showed marked heterogeneity in the ability of cancer cells to induce eIF2α phosphorylation upon …
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Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… gigas, to nitrate and characterized changes in protein expression, using a gel-based proteomics approach. Of the 642 protein spots detected, we found that 24 proteins (15 identified) changed expression in response to a 6-hour exposure to nitrate concentrations ranging from 0-73 mg/L, values that …
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Lipoproteins and heat shock proteins as measures of reproductive physiology in the soft shell clam, Mya arenaria
… were designed to examine the role of lipoproteins and heat shock proteins in normal physiological processes of the soft shell clam, Mya arenaria, including reproduction. The distribution of 14c triolein, an injected lipid tracer, occurred rapidly and was unaffected by the early stages of …
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Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
<p>Protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase, which catalyzes the addition of one or two methyl groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found …
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The effects of exercise training on cardiac and peripheral function in men and women
… induced greater expressions of some contractile proteins, creatine kinase-M and heat shock protein 70 kDa, in the vastus lateralis muscle, suggesting possible conversion towards a faster muscle phenotype, but only in men. We conclude that endurance training with exercise intensities <75 % HRR …
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The impact of acute heat exposure on the heat shock response (HSR) between males and females
While acute heat stress induces genomic changes in immune cells of young adults, the influence of ovarian hormones on the molecular response remains unclear, despite their documented role in thermoregulation. This study investigated the molecular response to acute heat stress in males (n=11), …
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Associations Among Beef Cattle Genotypes, Neospora Caninum Infection, and Reproductive Performance
… second study, tested for a relationship between heat shock protein 70 (Hsp70) genotypes and reproductive characteristics. Blood samples were collected from beef heifers (n = 165) being developed for replacements and Hsp70 genotypes (A1125C, C895D, G1851A, G2033C) were determined using a …
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Pre-treatment of patients undergoing cardiopulmonary bypass with hyperbaric oxygen : a prospective randomised double-blind evaluation of inflammatory response and neurocognitive outcome
… soluble endothelial selectin (sE-selectin), heat shock protein-70 (HSP-70) and cluster differentiation antigen-IS (CD-IS) which was significant in group-A was not so in group-B. Analysis of data from the neurocognitive tests also revealed that the overall neurocognitive dysfunction was …
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A proteomic investigation of the rhizomes of the resurrection fern Mohria caffrorum L. (Desv.) in response to desiccation
… rhizome specific peptide sequence database, 236 proteins were identified. Of these, 16 proteins increased in abundance while 14 declined, in the summer collected rhizomes. On the other hand, 16 proteins increased in abundance and 20 declined in the winter form. Western blot analysis confirmed the …
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A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is implicated in mRNA processing and ubiquitination functions and has been shown to be highly up-regulated in a number of cancers. In humans and mice,RBBP6 interacts with both tumour suppressors p53 and pRb, suggesting that it is …
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Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
… the synapses from the toxic binding of both proteins at the synapses can preserve synaptic health and cognitive function. With this goal in mind, the present study investigated the transcranial application of near infrared light (NIR, 600-1000 nm) as a potential treatment for AD. The primary …
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