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Showing 1 to 20 of 186 for “"Heat Shock Protein"”.
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Polymorphisms in heat shock protein receptors
Das extrazelluläre Hitzeschockprotein 70 (Heat Shock Protein 70, HSP70) kann als immunologisches Gefahrensignal fungieren und stimuliert die Aktivität zytotoxischer T-Lymphozyten und natürlicher Killerzellen. In diesem Kontext stellt HSP70 ein vielversprechendes Werkzeug im Rahmen immunologischer …
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Kinetics study of heat shock protein 70 expression
Heat shock protein 70 (HSP70) is well known for its efficacy in cardiac ischemia protection. The purpose of this study was to determine HSP70 expression kinetics in response to mild thermal stress. Currently there are no comprehensive experimental HSP70 expression kinetics data available. An …
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Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction
Tumor and cancer cells that over express heat shock protein 70: HSP70) are found to be multidrug resistant and thermo tolerant, creating a hurdle to existing therapy. Although HSP70 is recognized as an increasingly important drug target, the protein structure of this highly conserved chaperone …
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Characterization of Heat Shock Protein A12B as a Novel Angiogenesis Regulator.
<p>Previously, we cloned Heat shock protein A12B (HspA12B), the newest member of a recently defined subfamily of proteins distantly related to the Hsp70 family that are enriched in atherosclerotic lesions. We have found that HspA12B is predominantly expressed in vascular endothelium, and that it is …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
External stresses surrounding bone can stimulate heat shock proteins (HSPs), which are involved in anti-apoptosis, cell proliferation, and differentiation. In vitro stress modulation and HSP induction may be critical factors for enhancing bone regeneration. We investigated whether applying …
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Characterization of PFF1010c, a type IV Plasmodium fasciparum heat shock protein 40
… its molecular chaperones machinery particularly heat shock proteins (Hsps) to protect its protein constituents during physiological stress. Hsps are conserved molecules that constitute a major part of the cell’s molecular chaperone system. P. falciparum Hsps play an important cyto-protective role …
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Heat shock protein 27 inhibition of apoptosis in human breast cancer cells
… certain cytotoxic drugs and the presence of this protein could serve as a marker for aggressive tumors.
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The isolation and characterization of heat shock protein Hsp12 in Lipomyces starkeyi
The stress response protein Hsp 12 is induced in S. cerevisiae cells upon exposure to salt stress, heat shock, ethanol, and upon entry to stationary phase (Mtwisha et aI., 1998). In this study, the occurrence of proteins related to Hsp12 was investigated in a number of yeasts (namely, Saccharomyces …
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Towards the cloning of the human heat shock protein twenty-seven multigene family
… to clone closely-related members of the human heat shock protein 27 (hsp 27) multigene family. Genomic DNA was obtained from human A549 lung cancer cells. Colony hybridization and the Polymerase chain reaction identified the hsp 27 genes. Positive clones were subcloned into pGEM-3Z. The DNA …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
… contributes to increased apoptotic activity. Heat shock protein 70 (Hsp70) is a stress-induced protein and this protein can be a specific marker for this ischemic and apoptotic circumstance, preeclampsia. Therefore we compared immunohistochemical expression of Hsp70 in normotensive and …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… cascade. When there is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not obey the death signals that it receives. In this study, the molecular mechanism for the HSP 27 inhibition of the caspase cascade is described in human breast cancer cells that were engineered to …
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Defining a Role for Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo
… offer limited efficacy. Observations that heat shock proteins (HSPs) can serve as adjuvants in antitumor vaccines first suggested to us a link between HSPs and stress-induced vitiligo. Such proteins are marvelously well conserved throughout evolution, which has placed them in the spotlight …
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Investigation of Interaction between heat shock protein 70.14 (Hsp 70.14) and RBBP6 RING finger domain
… have exploited therapeutic potential of heat shock proteins (Hsps) as an alternative intervention against cancer because of their ever-presence in the pathology of different facets of cancer development. Studies have shown that tumour cells require Hsp chaperonin activities for survival …
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Relationships Between Expression of Heat Shock Protein Genes and Photosynthetic Behavior During Drought Stress in Plants
Heat shock proteins (HSPs) are expressed in response to environmental stresses. Compared to other kingdoms, plant HSP families are larger, presumably the result of adaptation to a wide range of stresses. Following on an analysis of drought stress characteristics in loblolly pine (Watkinson et al., …
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Sex Differences in Heat Shock Protein 72 Expression and Inflammatory Response to Acute Exercise in the Heat.
… possible sex differences in intracellular heat shock protein 72 (Hsp72), intracellular cytokines, and extracellular Hsp72 (eHsp72) before and after exercise in the heat. Nine non-heat acclimated women (W) (age 23 ± 3, BF 21 ± 2%, VO2max 58 ± 5 ml/kgFFM/min) and nine non-heat acclimated men …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
Heat shock protein (HSP) 90 is a molecular chaperone that regulates diverse cellular processes by facilitating activities of various protein clients. Recent studies have shown serum levels of the alpha cytoplasmic HSP90 isoform are elevated in newly diagnosed type I diabetic patients, thus …
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Role of heat shock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system
Intrazelluläres Hitzeschockprotein 70 (HSP70) gehört zum zellulären Stress-Antwort-System und kann Zellen vor unterschiedlichen apoptotischen Stimuli schützen. Extrazelluläres HSP70 hingegen kann Zellen des angeborenen und erworbenen Immunsystems aktivieren. Die akute Überexpression von …
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… permeability through up-regulation of the heat shock response resulting in occludin stabilization, and (2) depresses the exercise induced inflammatory response. Methods. Eight human subjects (n=8) participated in baseline (PRE) testing, a glutamine (GLN), and placebo (PLA) supplementation …
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Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens
<p>Heat stress (HS) has been reported to alter fat deposition in broilers, however the underlying molecular mechanisms are not well-defined; therefore, the objectives of the current study were to: (1) determine the effects of acute (2 h) and chronic (3 wk) HS on the expression of key molecular …
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In vitro interactions of the small heat shock protein chaperone human [alpha]B-crystallin with its physiological substrates in the lens [gamma]-crystallins
The passive chaperone a-crystallin, a small heat shock protein, is one of the ubiquitous crystallins in vertebrate lenses, along with the [beta][gamma]-crystallins. It is composed of two subunits (~ 20 kDa) aA- and [alpha]B-crystallin (aA- and [alpha]B-Crys), which form a hetero-oligomeric, …
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