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Showing 1 to 13 of 13 for “"Heart failure with preserved ejection fraction (HFpEF)"”.
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Investigation and analysis of heart failure with preserved ejection fraction (HFpEF) with Magnetic resonance
Heart Failure with preserved Ejection fraction (HFpEF) is a cardiovascular condition which is steadily on the rise. It is a major affliction in the elderly with higher incident rates in females and the obese. Exercise intolerance even to submaximal exercise is the cardinal symptom of this disease. …
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PRESERVE HFpEF: Designing a blended lifestyle intervention to improve physical function, dietary intake, and quality of life in multi-morbid older people who have Heart Failure with preserved Ejection Fraction (HFpEF)
Background Heart Failure with preserved Ejection Fraction (HFpEF), a type of heart failure, has been described as a ‘stealth syndrome’ and ‘the greatest unmet need in cardiology.’ These labels have arisen because of the increasing number of people receiving a diagnosis and the growing body of …
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FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
… as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are …
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The prevalence, profile, and prognosis of heart failure with preserved ejection fraction: A South African tertiary hospital experience
Background. There is limited data on heart failure with preserved ejection fraction (HFpEF) in Sub-Saharan Africa. We therefore aimed to describe the prevalence, profile and outcomes of HFpEF patients admitted to a South African tertiary hospital. Methods. We retrospectively reviewed all …
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Modulation of Cardiac Titin Stiffness in Physiological and Pathophysiological States
… and pathophysiological states including Heart Failure with Preserved Ejection Fraction (HFpEF) which is marked by increased diastolic stiffness. Here, I investigated the effects of titin phosphorylation by two kinases, ERK2 and CaMKIIδ, at the level of the protein and the myocardium. …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
Background: Heart failure with preserved ejection fraction (HFpEF) represents an increasingly significant clinical burden. Recent treatment guidelines recommend sodium-glucose cotransporter-2 inhibitors (SGLT2i) as foundational therapy, with the addition of either mineralocorticoid receptor …
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Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
… to reciprocally influence cardiac function, with impaired diastole and left ventricular (LV) stiffness causally linked to endothelial dysfunction and coronary microvascular inflammation. SMTNL1, also highly expressed in skeletal muscle, can impact the energy metabolism and insulin sensitivity …
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern due to its increasing incidence alongside a lack of effective therapeutics. Understanding how this condition develops is therefore of the utmost importance in order to develop preventative strategies. As such, …
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Lrg1 in preeclampsia and heart failure: role as a biomarker and mediator of disease
… in women who develop PE during pregnancy, with particular interest in women with diabetes. We found that LRG1 plasma concentration is increased in women who developed PE, and this occurred specifically in diabetic women. In vitro studies revealed that the expression of LRG1 from trophoblast …
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Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
… of Cardiology long-term out-patient registry, heart failure with preserved ejection fraction (HFpEF) accounts for approximately 16% of heart failure cases, with survival rates failing to improve due to the lack of effective treatments and the increasing prevalence of co-morbidities. It has been …
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Soft Robotic Platforms for the Simulation of Cardiovascular Disease and Device Development
… diseases, specifically aortic stenosis (AS) and heart failure with preserved ejection fraction (HFpEF), affecting over 40 million people worldwide. This work first describes the development of a tunable and biomimetic soft robotic aortic sleeve that can re-create the anatomy and hemodynamics of …
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
Objective: Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles of the heart, plays a unique role in the manifestation of disease. …
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Improving Mass Spectrometry-Based Metabolite Identification and Quantification and Application to Cardiovascular Disease
… to profile the full spectrum of the metabolome, with identification of metabolites aided by existing spectral libraries. In contrast to many successful applications of targeted metabolomics to CVD, early applications of non-targeted profiling have resulted in several pitfalls due to lack of rigor …