Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Heart development"”.
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregulation of Ca2+ homeostasis in a cardiomyocyte cell line after TCE exposure (Caldwell, Thorne et al. 2008). We hypothesized that misregulation of Ca2+ homeostasis alters …
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Regulation of Connexin43 by Phosphorylation in Heart Development
… transduction through these gap junctions during heart formation. Reportedly, mutations which replace potentially phosphorylatable serines within the Cx43 protein are associated with heart malformations (Britz-Cunningham et al.. 1995), highlighting the importance of determining the levels of Cx43 …
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Functional analysis of SMAD7 in mammallian heart development
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Control of heart development in the Mexican axolotl (Ambystoma mexicanum).
… of the embryonic primordia which form the heart are well known. However, the processes whereby the heart-forming mesoderm is induced, and the later mechanisms controlling the differentiation and morphogenesis of the heart are only poorly understood for any system. An important model system …
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The epigenetics and role of Dopa Decarboxylase in heart development
… imprinting in the developing and neonatal mouse heart with transcription occurring solely on the paternally inherited allele, with the maternally inherited allele epigenetically silenced. In all other tissues where Ddc_exonla is expressed transcription occurs from both parentally inherited …
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Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
The early morphogenetic mechanisms involved in heart formation are evolutionarily conserved. The Drosophila heart, known as the dorsal vessel, functions as a pulsatile tube-like organ containing an inner layer of contractile cardial cells that adhere tightly to an adjacent layer of pericardial …
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The Role of UNC-45 in Heart Development and Human Breast Cancer
… all cell types, whereas UNC-45B/b only exists in heart and skeletal muscles. This thesis investigated the distinct roles of UNC-45 isoforms in heart development and breast cancer progression. As a molecular chaperone, mouse UNC-45b directly bound cardiac muscle myosin II and transcription factor …
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The impact of suboptimal maternal diet on fetal heart development: Identifying targets for intervention
… and contractile profiles within the fetal heart. Across studies, it was highlighted that high-risk cardiac phenotypes are present even with normal fetal body weight, challenging the traditional view that birth weight is a predictor of cardiovascular disease (CVD) risk. Mechanisms underlying …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… to VPA can have detrimental effects on embryonic development. Specifically, in utero exposure to VPA has been associated with a higher risk of congenital heart defects. In spite of this, expectant mothers are advised to continue taking it throughout pregnancy to prevent seizures. One proposed …
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Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
… signals and generate the cells that form the heart valves and atrioventricular septum. The Notch and TGFf3 pathway are thought to act in parallel to modulate endothelial phenotype and promote EndMT. Vascular endothelial (VE) cadherin is a key regulator of cardiac endothelial cell phenotype and …
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Elucidation of the Cardiac Myogenesis Regulatory Network
Heart development has been extensively studied in numerous organisms throughout the twentieth century. The timing of key inductive signals and the expression of many critical transcription factors have been mapped across a variety of model systems. A collective image of the various stages of …
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Investigating microRNAs during cardiac development in the chick
The heart, the first organ to function in developing vertebrate embryos1, is affected by congenital defects in roughly 1% of the worldwide human population. These abnormalities frequently require treatment for the entire lifespan of the affected individual2,3. microRNAs are an exciting class of …
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An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis
… in regulating cardiomyocyte differentiation and heart tube formation, but excess RA inhibits cardiomyocyte differentiation. We have used microarray technology and whole mount in situ hybridization to investigate the mechanism by which RA might alter cardiogenesis. Our results showed that RA …
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Molecular mediators of cardiac-specific enhancer activation
… determining the genetic pathways responsible for development. Heart development is particularly sensitive to precise control of gene programs as faulty regulation leads to congenital heart defects (CHD), the leading cause of infant mortality. Although sets of TFs have known roles in heart …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… and activities leading to aberrant brain and heart development in the fetuses and neonates. In the first part of project, we tested the hypothesis that maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. This was accomplished by …
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Characterisation of the role of Sox4 in mouse embryonic development
… is revealed by the high incidence of heart phenotypes resulting from mutation to any of a vast number of genes across multiple pathways. Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in aspects of heart development. A …
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The Chemokine Receptor CXCR7 Functions in Endocardial-Derived Cells to Regulate Cardiac Valve Remodeling
… one killer in developed countries and congenital heart diseases are the most common birth defects worldwide. The heart supplies nutrients and oxygen to the entire body, therefore the proper development and function of the heart is essential for survival of an organism. During looping and …
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Investigation into the genetic nature of familial congenital bicuspid aortic valve
… we hypothesized that congenital BAV (cBAV) was a developmental defect inherited as an autosomal dominant trait with variable penetrance. We evaluated the NOS3 candidate gene based on the reported phenotype of a mouse mutant, and the FBLN2 and TIMP4 genes based on their role in heart development. …
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Multinuclear and Mononuclear Polyploidy in the Drosophila Hindgut and Heart
… proteins up to at least 62 kDa. This sharing is developmentally regulated and requires membrane trafficking and gap junction genes instead of canonical cell-cell fusion or incomplete cytokinesis factors. This mechanism of sharing does not appear to involve plasma membrane breaches, a novel way …
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How the Heart Grows: From Multi-scale Data to a Multi-scale Model
The heart is the first organ to form and the first to function during early development. Embryological heart development consists of a series of events believed to be highly conserved in vertebrates. Cardiac precursor cells form a cardiac crescent at the embryonic midline. Fusion of the cardiac …
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