Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Heart cells"”.
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A study of phase resetting, mutual entrainment, and modified ventricular parasystole using a model of coupled heart cells
… of coupled mathematical models of cardiac cells. Unlike previous studies of cell interaction which have used simplified models of a general cardiac cell or oscillators characterized only by their phase transition curves the present work incorporates the more physiologically realistic cell …
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Molecular Mechanisms of Physalia Physalis Venom Modulation of Cardiac and Vascular Functions
… calcium influx of cultured embryonic chick heart cells in a dose dependent manner by activating L type calcium channels. The increased calcium influx is consistent with the positive inotropic action on the cultured heart cells observed under the microscope. This effect is completely …
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Monitoring single heart cell biology using lab-on-a- chip technologies
… structures for the analysis of single cells; however, substantially less work has focused on developing "active" assays, where the cell‘s metabolic and physiological function is itself controlled on-chip. The heart attack is considered the largest cause of mortality and morbidity in the …
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Force regulation in contractile cells by chemical and mechanical signaling
… and disease. We approach this by investigating cells from two types of tissues: heart tissue cells and epithelial tumor cells. Chemical signaling by intracellu- lar calcium directly regulates heart contractions. Altered calcium handling in heart cells is known to affect force generation in the …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… increase in HO-1. Protandim supplemented cells were protected against hydrogen peroxide-induced apoptosis as assessed by TUNEL (35% apoptotic in untreated vs. 5% apoptotic in Protandim treated). These findings support the use of Protandim as a potential method for upregulation of …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 provides a …
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Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity
… distribution of anticancer drugs to healthy cells pose challenges that limit the clinical application of these drugs.</p> <p>Epirubicin (EPI) is a topoisomerase II Inhibitor and an antineoplastic agent used to treat acute myeloid leukemias, multiple sclerosis (relapsing or secondary …
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Modeling oxygen requirements in ischemic cardiomyocytes
Ischemic heart disease remains a leading cause of death globally and in the US. The most common ischemic event is a heart attack, where one or more arteries are obstructed and the cardiac muscle is deprived of oxygen. Although removing the blockage and allowing reperfusion can prevent death, at the …
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Effects of magnesium and calcium upon excitation-contraction coupling in the heart
… coupling. Calcium metabolism in the heart undergoes developmental changes during early postnatal life and some of these changes may concern the activity of the SR. Using the technique of oxalate-supported Ca2 uptake into SR vesicles from rat hearts, the developmental changes in the …
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Functional analysis of tcf21 and tbx20 in zebrafish
… opposed to mammals, are able to regenerate new heart cells without significant scar tissue. Heart attacks, a leading cause of death in the United States, leave behind substantial scar tissue that weakens the heart and leads to a greater chance of a repeated cardiac event. Many genes and major …
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Regulation and patterning of cell differentiation and pluripotency
… BMP-2 expression vector, to mesenchymal stem cells cultured in a microfluidic 3. Patterning of the Nanog gene expression in embryonic stem cells, using a microfluidic device, to establish differentiation - pluripotency boundaries that mimic the developmental processes in vivo. In the first …
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3D printing of biological machines for biology and medicine
… is a set of sub-components consisting of living cells and cell-instructive micro-environments that interact to perform a prescribed task. Cell types such as neurons, muscle cells, and endothelial cells can be programmed for sensing, information processing, actuation, protein expression, or …