Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Healthspan"”.
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Ketosis Suppression and Ageing (KetoSAge): Suppression of ketosis negatively affects multiple biomarkers associated with chronic diseases and ageing
… of hyperinsulinaemia that reduce life and healthspan. Hyperinsulinaemia pathologies present with increases in loss of function at all levels, from: the cellular, tissue, organ and ultimately systemic. Sustained ketosis with euglycaemia is a measurable metabolic phenotype to indicate absence …
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Exploring the role of the unfolded protein response in C. elegans neurons
… system of C. elegans increases the lifespan and healthspan of worms through UPRER induction in the intestine cell non-autonomously. To investigate XBP-1s-dependent changes in the nervous system of these animals, we conducted tissue-specific RNA-Seq in neurons. This approach allowed us to …
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The design and numerical analysis of a microfluidicssystem for osteogenic differentiation of mesenchymal stemcells.
… rising over the last decades, unfortunately, the healthspan of the population has not followed the same trend. Therefore our society is metwith a demand to cultivate and expand our knowledge of regenerative medicine withskeletal tissue being in high demand. The advancement of micro-bioreactors, …
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The Automatic Tracking Of <i>Caenorhabditis elegans</i> And Its Use In Determining Genetic Function
… in <i>asic-2</i> cause increased lifespan and healthspan and a reduction in dauer entry in response to exogenous, purified ascarosides. Mutations in <i>acd-5</i> cause decreased lifespan and healthspan and a reduction in dauer entry in response to crude dauer pheromone. This suggested that the …
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The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
… (OA) is among the top 10 diseases limiting human healthspan, and no disease modifying therapies currently exist. OA is a degenerative disease of the whole joint, characterized by articular cartilage loss, subchondral bone sclerosis, meniscal calcification, synovitis, and skeletal muscle …
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The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… manipulation that can increase both lifespan and healthspan in a variety of species. Underlying these increases are improvements in metabolic health and reductions in cancer incidence. Despite these physiological improvements, the regulation of skeletal muscle mass is extremely sensitive to …
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Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster
… results confirm that IIS modulated lifespan and healthspan independently and reducing IIS in neurons caused detrimental functional effects in flies.
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Metabolic influences on ageing in Caenorhabditis elegans: A time series multi-omics and metabolic modelling study
… of the pathways that extend lifespan and promote healthspan are known to be metabolic and relate to managing the balance of energy availability to optimise resource usage and survival during times of scarcity. The model organism Caenorhabditis elegans, a small transparent nematode worm that …
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Regulation of ageing by electrical synapses in the Nematode Caenorhabditis elegans
… a battery of tests which examined the animals’ healthspan and resistance to oxidative stress. These assays revealed that unc-9 mutants stay motile and responsive for longer. Furthermore, our results of experiments with pro- and anti- oxidative agents suggest that direct coupling through UNC-9 …
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Metabolomics of Mammalian and Cellular Models of Aging
… in a manner consistent with increases in healthspan.</p> <p>Purines are molecules essential for many cell processes, including RNA and DNA synthesis, regulation of enzyme activity, protein synthesis and function, energy metabolism and transfer, essential coenzyme function, and cell …
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Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology
… Rapamycin treatment also resulted in prolonged healthspan in KO mice, as indicated by the offset of neurological damage, maintenance of weight and body fat, and the improvement of deleterious behavioral phenotypes. Systematic testing of potential mechanisms mediating these effects led us to …
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Energy metabolism and aging
… and the many characteristics of an extended healthspan have been known for some time in Ames dwarf mice, the revelation that dwarf mice have improved energy metabolism was less than a decade ago. This finding came about at the molecular level (improved efficiency of the electron transport …
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STUDY OF EPIGENETIC REGULATORS AND SIGNATURES OF AGING
Epigenetic alteration is a hallmark of aging, but it remains unclear if perturbation of transcription machineries may affect longevity. NELF-mediated pausing of RNA polymerase II (RNAPII) constitutes an important step in transcription regulation. I found that halving NELF-A level in heterozygous …
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DNA methylation: a model system for the study of ageing
DNA methylation is an important epigenetic mark spanning all of life's kingdoms. In humans, DNA methylation has been associated with a wide range of age-related pathologies, including type II diabetes and cancer. More recently, in humans, changes in DNA methylation at specific positions in the …
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Optimizing Pharmacological Lifespan Extension: Testing Chemical Compounds for Additive Effects on Longevity
<p>No abstract available</p>