Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Health Sciences, Toxicology."”.
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Bioavailability studies of folate in humans.
Bioavailability studies of folate in humans.
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Functional Characterization and Evolutionary Analysis of Lepidopteran Cytochrome P450 Genes Involved in Plant -Insect Interaction
Herbivorous animals rely on very sophisticated detoxification systems, such as the cytochrome P450 monooxygenases (P450s), to overcome the chemical defense systems of plants. Understanding the driving force behind the evolution of these systems that is promoted by gene duplication will help us …
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Toxicology of Three Plant Neurotoxins in Drosophila Melanogaster, Gallus Gallus Domesticus, and Mus Musculus
To elucidate the fate of coniine within the body, the feces, urine, and body tissues of house mice were examined after oral administration of a sub-lethal dose of coniine. Coniine was quickly eliminated.
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The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
In conclusion, both ethanol and acetaldehyde are capable of enhancing carcinogen-DNA adduct formation and inhibiting removal. However, these effects are dependent on the concentrations of ethanol or acetaldehyde, the time of exposure and the dose of carcinogen. Additionally, these effects, …
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Isolating Antigenotoxic Components and Antioxidants From Commercial Corn Processing by -Products
The identification and isolation of antimutagens and antioxidants are very important for setting up prevention strategies for environmental toxicants. Such research may lead to a future where agricultural crops would be raised for both their pharmaceutical and agronomic value. Opening a new niche …
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Effects of Developmental Exposure to Environmental Contaminants on the Auditory System
Polychlorinated biphenyls (PCBs) and methylmercury (MeHg) are ubiquitous environmental contaminants to which humans are exposed, primarily via consumption of contaminated fish and seafood. Developmental exposure to these contaminants can result in a variety of neurotoxic effects, including …
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Characterization of the Increased Risk of Attention Deficit Hyperactivity Disorder Following Early-Life Exposure to Deltamethrin
Unmasking the mechanistic etiology of neurodevelopmental disorders remains at the forefront of neuroscience research. To this end, epidemiological studies have sought to identify key risk factors driving these disorders. Unsurprisingly, early-life exposure to ubiquitous pesticides which target the …
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Investigation of ARNT isoform-specific regulation of AHR signaling
The aryl hydrocarbon receptor nuclear translocator (ARNT) is alternatively spliced into two distinct isoforms, isoform 1 and 3. Although ARNT is found to be critical in immunity, xenobiotic, and hypoxic response, ARNT isoform-specific function has yet to be investigated. We previously demonstrated …
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Utilization of a scientifically operated charge-coupled device detector for high-performance thin-layer chromatographic analysis
A high-performance thin-layer chromatographic (HPTLC) separation system coupled with a scientifically operated charge-couple device detector (CCD) has been developed to improve the identification and quantitative analysis of pharmaceutical products and natural toxins. The combination of the fast, …
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Validation of the Planarian Bioassay With Defined Mixtures and Testing Against Other Bioassays With Contaminated Samples From Pakistan
The main objectives of this study were to: (a) develop the planarian model to assess toxicologic effects caused by pure chemicals and chemical mixtures; (b) assess chemical contamination in environmental samples from selected areas in Pakistan where industrial contamination was suspected; (c) test …
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Thyrotoxic and dopaminergic effects of polychlorinated biphenyls
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:44Z Item is restricted indefinitely.
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Effects of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels in prepubertal female rats
A 2-day short-term bioassay, using prepubertal female Sprague-Dawley rats, was developed to study effects of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels. Three approaches have been used to study the multiple effects of PCB …
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Comparison of polychlorinated biphenyl profiles in rat, fish and human tissues; the effects of consuming Great Lakes fish
The food chain transfer of Polychlorinated Biphenyl (PCB) congeners was assessed in rat and human tissue after the consumption of contaminated Great Lakes fish. Fish from Lake Superior (LS), Lake Michigan (LM), and Lake Huron (LH) were examined for either total PCB or specific congener …
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The Mechanism of Cyanohydroxybutene Induced Glutathione Elevation: The Role of Gamma-Glutamylcysteine Synthetase
Cyanohydroxybutene (CHB; 200 mg/kg po) causes a 2- and 7-fold elevation in glutathione (GSH) in liver and pancreas, respectively. The mechanism of elevation is currently unknown. In an attempt to identify the mechanism of this GSH induction, the effect of CHB on hepatic and pancreatic …
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Synthesis and Pulmonary Toxicity of Several 3-Furyl Ketones: Evidence for the Position of Metabolism by Cytochromes P-450
Pulmonary toxicity of naturally occurring 3-furyl ketones is of increasing concern to animal science. Bioactivation of these heterocycles by pulmonary cytochromes P-450 is necessary for their toxicity, but the mechanism of this bioactivation is not clearly understood. Using a series of 3-furyl …
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The effect of modification of mixed function oxidases and inhibition of enterohepatic circulation on concentration of estrogens in plasma in laying hens (Gallus domesticus)
The rate of metabolism and recirculation contributes to the rate of excretion and to concentration in the circulation. Steroids are substrates for mixed function oxidases (MFO). Enterohepatic circulation (EHC) of estrogens prolongs the half life of estrogens. Thus, the amount of recirculation and …
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Evaluation of the induction of rat hepatic and pancreatic glutathione S-transferases by treatment with the cruciferous nitrile, cyanohydroxybutene
Cyanohydroxybutene (CHB) is a nitrile derived from glucosinolates commonly found in cruciferous plants. Glucosinolate derivatives are believed to provide protection against carcinogens by inducing detoxifying including the glutathione S-transferase isoenzymes (GSTs). The GSTs catalyze the …
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Light Enhanced Toxic/tumorigenic Potential of Trinitrotoluene (Tnt) and Analogs
The acute toxicity of TNT, 2-amino,-4,6-dinitrotoluene (2A) and 4-amino,-2,6-dinitrotoluene (4A) to Photobacterium phosphoreum (Microtox reagent), Daphnia magna (daphnia), and Dugesia dorotocephala (planaria) was enhanced by near-ultraviolet light (nUV) coexposure. The light enhanced toxicity of …
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Activity of Sodium Ion, Potassium Ion in the Epididymis of the Rat
Na$\sp+$,K$\sp+$-ATPase enzyme activity and its regulation was determined in the ductuli efferentes and the initial segment of the epididymis of the rat. Electron microscopic localization of Na$\sp+$,K$\sp+$-ATPase demonstrated enzyme activity along the cytoplasmic side of the plasmalemma of the …
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Neurobehavioral and neurochemical effects of ortho-substituted polychlorinated biphenyl congeners in perinatally exposed rats
Polychlorinated biphenyls (PCBs) are persistent contaminants in the environment. PCBs are lipophilic and from the environment bioaccumulate in living organisms. People are exposed to PCBs through the food chain. PCB exposure during development of the central nervous system (CNS) results in …
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