Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Health Sciences, Radiology"”.
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Non-Invasive Detection of Anaerobic Metabolism in Exercising Muscle Using Proton MRI
The second, and major, component of this thesis concerned the exercise-induced increases the 1H T2 of muscle water. The hypotheses were tested that the T2 increase results from increased intracellular volume (VI), decreased intracellular pH (pHI), and/or changes in magnetization transfer (MT) or …
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Identifying Tumor Vascular Permeability Heterogeneity Using Reduced Encoding Techniques
"In our model, female Sprague Dawley rats with N-ethyl-N-nitrosourea (ENU) induced mammary tumors imaged with fast T1-weighted gradient echo DCE MRI following a Gd-DTPA injection, there is a window of resolutions that detects similar PS ""hot spots"" compared to those obtained from the clinical …
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Small Gadolinium Oxide Contrast Agents: A Novel Class of Multi-Modality Contrast and Therapeutic Agents
Towards this aim experimental studies will be presented for the biophysical characterization of gadolinium oxide particulate contrast agents as a novel class of prototype multi-modality contrast agent. In chapter 2 an analysis of the MR contrast enhancement and X-ray attenuation properties of small …
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I. Synthesis of Myocardial Imaging Agents for Diagnosis of MCAD Deficiency. II. Synthesis of [fluorine-18] Fluoroaryl Estrogens as Receptor Based Tumor Imaging Agents for Breast Cancer
The synthesis of a (fluorine-18) fluoroaryl estrogen in no-carrier-added form requires the use of ($\sp{18}$F) F$\sp-$. A great amount of effort has been made toward incorporation of ($\sp{18}$F) F$\sp-$onto an electron-rich aromatic ring, but none have found general application. Several strategies …
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Mapping Anisotropic Tissue Fiber and Microvasculature Architecture With Diffusion MRI: Application to Skeletal Muscle and White Matter
The present thesis focuses on the development of acquisition procedures and model-based analysis tools for the simultaneous characterization of anisotropic tissue fiber and microvasculature architecture in vivo, and their tissue-specific implementation in two areas of particular radiological …
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Electronic Relaxation Properties of Gadolinium Based MRI Contrast Agents
Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
In addition to our non-steroidal work, we have designed and synthesized some high affinity steroidal compounds to probe the mechanism of androgen delivery to the cellular AR transcription mechanism. Sex hormone binding globulin (SHBG) binds testosterone, the principal circulating androgen, in high …
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Small Molecule Rhenium Carbonyl Complexes: Model Integrated-Design Technetium Estrogen Receptor Ligands for Tumor Imaging
It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been …
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Synthesis, Characterization, and Evaluation of Silica-Nanosphere-Based Contrast Agents for Biomedical Application
Following cytotoxicity studies, MRI contrast agents were ultimately introduced into the silica nanospheres for dual functionality. Gd-DTPA, a commonly used MRI contrast agent, was chosen as an appropriate candidate for initial study. Through an in vivo experiment using tadpoles, we demonstrated and …
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Motion -Compensated 3-D Generalized Series Imaging
Three-dimensional magnetic resonance (MR) imaging is highly desirable from the standpoints of minimum voxel size, volumetric coverage and signal-to-noise efficiency. Unfortunately, long scan times have traditionally precluded the use of 3-D imaging in applications where simultaneous resolution of …
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Estimating the Medical Ultrasound in Vivo Power Spectrum
This thesis considered the estimation of the in vivo power spectrum from the backscattered waveforms by finding the total attenuation along the propagation path. The total attenuation was estimated by assuming model for the scatterers (i.e., spherically symmetric Gaussian impedance distributions of …
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Ultrasonic Characterization of Three Animal Mammary Tumors From Three-Dimensional Acoustic Tissue Models
This dissertation investigated how three-dimensional (3D) tissue models can be used to improve ultrasonic tissue characterization (UTC) techniques. Anatomic sites in tissue responsible for ultrasonic scattering are unknown, which limits the potential applications of ultrasound for tumor diagnosis. …
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Spectroscopic Optical Coherence Tomography: Mechanisms, Methodology, and Applications
Depending on the contrast mechanism, the applications of SOCT imaging can be classified into two imaging modes: absorption-mode SOCT and scattering-mode SOCT. Absorption mode SOCT is concerned with mapping out the spectral absorption, while scattering mode SOCT is concerned with mapping out the …
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Feedback Control of Phased Array Electromagnetic Hyperthermia Using MRI Temperature Mapping
This work focuses on closed loop control of microwave hyperthermia using noninvasive MRI thermometry. The following developments are reported here: (1) An integrated MR-microwave hyperthermia system intended for small animal studies was designed and built. (2) A new technique is presented that …
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Longevity, Oxygen Toxicity and Radiation-Enhanced Resistance to Oxygen in Tribolium Confusum (Mortality, Hyperbaric, Radiation Factors, Induced Repair)
Sublethal doses of ionizing radiation increase longevity in a variety of insects, suggesting that irradiation may retard the age-dependent decline of physiological functions. There have been no systematic investigations of the response of irradiated populations to stress, however.
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Effect of Hyperthermia on Radiation Damage and Its Repair in Tribolium Confusum
Made available in DSpace on 2014-12-14T05:40:42Z (GMT). No. of bitstreams: 1 7714975.pdf: 2022644 bytes, checksum: f76c7dcd858cf3fbee17fa19a5e41416 (MD5) Previous issue date: 1977
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Growth and Viability of Aedes Albopictus Cell Line in Vitro After Cesium-137 Gamma Irradiation
Made available in DSpace on 2014-12-14T13:39:35Z (GMT). No. of bitstreams: 1 7524264.pdf: 5953932 bytes, checksum: d9e7a3192462ac14c8700265237df0d7 (MD5) Previous issue date: 1975
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Late Effects of Fission Neutron and Cobalt-60 Gamma-Radiation on the Hematopoietic Stem Cell Compartment in the Mouse
Made available in DSpace on 2014-12-14T13:39:40Z (GMT). No. of bitstreams: 1 7715033.pdf: 2940664 bytes, checksum: e5829618942bc352c272e90ba6f0926f (MD5) Previous issue date: 1977
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The Ultraviolet-Ray and X-Ray Response of The Desmid, Micrasterias Decemdentata
Made available in DSpace on 2014-12-11T22:22:17Z (GMT). No. of bitstreams: 1 7212195.pdf: 3930829 bytes, checksum: 1fb1be79012bfcb3ec997575a13147a3 (MD5) Previous issue date: 1971
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The effects of radiation on pregermination plant seeds
Using pregermination plant seeds as a model for proliferative tissue, we have investigated the effects of gamma radiation and hyperthermia on barley and alfalfa. Barley seeds soaked for up to 16h prior to irradiation were given doses of gamma radiation up to 100 Gy, and alfalfa seeds soaked for up …
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