Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 172 for “"Health Sciences, Pharmacy."”.
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Microencapsulation of Bacillus calmette-guerin for use in cancer immunotherapy.
Microencapsulation of Bacillus calmette-guerin for use in cancer immunotherapy.
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Comparative effectiveness and safety of high-efficacy disease-modifying agents (DMAs) and moderate-efficacy DMAs in patients with multiple sclerosis
Objective: The specific aims of this study are to (1) evaluate the factors associated with the initiation of heDMAs and meDMAs, (2) examine the comparative effectiveness of relapses between heDMA users and meDMA users, and (3) assess the infection risks for heDMAs and meDMAs among patients with MS. …
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Development of a topical epigallocatechin gallate (EGCG) formulation
Epigallocatechin gallate (EGCG) is a potent polyphenoclic antioxidant extracted from green tea. Due to its antimutagenic and antitumor activities it is a promising candidate for use in topical formulations for skin cancer prevention. The overall objective of this dissertation was to develop a …
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Essay on Incentives for Pharmaceutical Research: A Double Push -Pull Program
This dissertation contributes to a better understanding of the pharmaceutical market for neglected diseases and proposes a program that creates incentives and encourages research and development of new medicines for neglected diseases. The current patent system ensures that incentives are directed …
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In Vitro Effects of Actively Delivered Coencapsulated Curcumin and Cisplatin Nanoliposomes on Squamous Oral Carcinoma
Multidrug carriers were also formulated using a Dipalmitoyl Phosphatidylcholine (DPPC) as a primary lipid, with incorporation of a lysolipid to achieve controlled release of the drugs loaded within. Diagnostic ultrasound energy was then employed as a tool to achieve controlled release from the …
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Determinants of Value in Pharmaceutical Innovation: A Property Rights Approach
This study has profound implications for business policy in the pharmaceutical industry. It provides a holistic approach to the impact that firm characteristics have on value created by new drug introduction. Awareness of the relative importance of such characteristics can enable management to …
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Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery
Protein burst on injection was entirely eliminated when the protein particle was densified with stearic acid and placed in a slow phase-inverting depot formulation. Particle densification can potentially be used with any protein or highly soluble drug agent, unlike other techniques that are protein …
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The Design and Characterization of a Multiple Pinhole Collimator and Its Applications in Biopharmaceutics
A 4-pinhole collimator was designed to image small objects and its characteristics were studied. The field of view formed by this collimator was a conically-tipped pyramid with a minimum object distance of 3 cm. The line-spread function at 8 cm from the collimator had a full-width-half-maximum of …
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Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
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K-Ras4B: Investigation of Protein-protein and Protein-phospholipid Interactions.
K-Ras4B: Investigation of Protein-protein and Protein-phospholipid Interactions.
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1. X-ray crystallographic analyses of the gene V protein from Ff bacteriophage, a single-stranded DNA-binding protein, and its Y41 mutants 2. X-ray crystallographic analyses of several anticancer drugs and their interactions with DNA
In biological systems, DNA/RNA-protein interactions as well as drug-DNA interactions play important roles in genetic processes. A fundamental understanding of these processes requires a detailed structural knowledge of DNAs, proteins, drugs, as well as their complexes with each other. Gene V …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
… Seasonal influenza remains a major public health concern, contributing to substantial morbidity, mortality, and economic burden each year. Although antiviral medications are effective in reducing symptom duration and preventing severe influenza-related complications, their real-world …
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