Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Health Sciences, Pharmacology."”.
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Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
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Selective modulation of the platelet thromboxane A2/prostaglandin H2 receptor by omega-3 fatty acids.
Selective modulation of the platelet thromboxane A2/prostaglandin H2 receptor by omega-3 fatty acids.
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BIOCHEMICAL BASIS OF IMPAIRED HEPATIC MICROSOMAL DRUG METABOLISM IN THE NEONATE.
BIOCHEMICAL BASIS OF IMPAIRED HEPATIC MICROSOMAL DRUG METABOLISM IN THE NEONATE.
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MORPHOLOGY AND PHYTOCHEMISTRY OF DATURA INOXIA MILL.
MORPHOLOGY AND PHYTOCHEMISTRY OF DATURA INOXIA MILL.
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Investigation of resveratrol metabolism using liquid chromatography-mass spectrometry.
Investigation of resveratrol metabolism using liquid chromatography-mass spectrometry.
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Design and synthesis of novel factor Xa inhibitors.
Design and synthesis of novel factor Xa inhibitors.
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ENZYME INDUCTION BY THE PORPHYRINOGENIC DRUG ALLYLISOPROPYLACETAMIDE.
ENZYME INDUCTION BY THE PORPHYRINOGENIC DRUG ALLYLISOPROPYLACETAMIDE.
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Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis.
Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis.
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Regulation of p115RhoGEF by Galpha13.
Regulation of p115RhoGEF by Galpha13.
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder which results in the selective loss of the medium spiny neurons in the striatum. The neuropathological and behavioural deficits of HD can be modeled in rats by injection of the NMDA receptor agonist quinolinic acid (2,3 …
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Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.
The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both …
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The FP prostanoid receptor: Isoforms and functional studies
Prostaglandin F₂(α) (PGF₂(α)) is a locally acting hormone derived from arachidonic acid that is involved in a diverse range of physiological functions including regulation of the corpus luteum and regulation of intraocular pressure. The goal of this research has been to characterize the signaling …
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In vivo and in vitro toxicity of M-741 (3,15 di-(5,5-dimethyl-3-N(-(cyclopropylmethylinium)-(N-propylinium));-1-cyclohex-1-enyl);-7,11,18,21-tetraoxa-3,15-diazatrispiro (5.2.2.5.2.2); heneicosane)
M-741 (3,15 di-[5,5-dimethyl-3-N[-(cyclopropylmethylinium)-(N-propylinium]-1-cyclohex-1-enyl]-7,11,18,21-tetraoxa-3,15-diazatrispiro [5.2.2.5.2.2] heneicosane produces hepatotoxicity in rats following intravenous administration. Hepatocellular pathology is characterized by parenchymal cell necrosis …
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The human cannabinoid CB(1) receptor stably expressed in Chinese hamster ovary cells provides a model system to predict the pharmacological effects of cannabinoids in man
Since the cloning of the only known cannabinoid receptor in the human brain, CB₁, scientists have been trying to elucidate the mechanisms of action of this receptor. The possibility of yet unidentified cannabinoid receptors in human brain makes it important to be certain that any results obtained …
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Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces
In separate studies, myoglobin has been used to study the fluorescence lifetime behavior of oriented biomolecular surfaces. These studies have revealed differences in lifetime between differentially oriented myoglobin molecules, consistent with differential accessibility of the heme pocket to …
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Single-Channel Studies of Agonist Interactions With the Neurotransmitter-Binding and Pore Domains of the Muscle Nicotinic Acetylcholine Receptor
The nicotinic acetylcholine receptor, a ligand-gated ion channel, is activated by a variety of naturally occurring and synthetic ligands. The overall 'response' elicited by any ligand of the nicotinic receptor is not only a consequence of its binding to the extracellular neurotransmitter-binding …
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Clinical Globalization: Pharmaceutical Research in the Global South
… the United States, an uneven global gradient of health care access, and changing health demographics in the Global South---have prompted the development of an extensive international infrastructure for conducting clinical trials. This infrastructure is not only technical and physical, but also …
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A Structural and Functional Analysis of the Human Angiotensin II Type-2 Receptor
In the third series of experiments we used synthetic peptides derived from the amino acid sequence of the cytoplasmic loops and tail of the AT 2 receptor are used to determine what regions are important to G-protein activation. These studies will map the G-protein coupling regions of the human AT2 …
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NMR, Crystallographic and Computational Investigations of Peptides, Proteins and Bisphosphonates: New Paradigms for Rational Drug Design
"The standard approaches to lead identification and optimization involve a long and expensive process including random and nonrandom (targeted or focused) screening. Given the limited success of these standard approaches, an alternate route to develop a new drug would be to start with an existing …
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Synthetic Studies in the Didemnin Series
Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl …
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