Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 120 for “"Health Sciences, Oncology"”.
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Uncertainty in Internet-Based Cancer News
Uncertainty has been defined and studied in many ways; however, no universal message-level coding scheme for dimensions of uncertainty has been developed. A content analysis of 1,120 Internet-based cancer news articles was completed, in which a presence/absence scale for five theoretically derived …
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Cancer Survivorship: Couples' Communication and Adjustment After Treatment Is Complete
… negotiations, (c) maintaining control of health, and (d) disrupted lives. Potential dilemmas associated with each challenge complicated couples' coordination of talk. The results are discussed in terms of the multiple goals and multiple meanings inherent in couples' communicative and …
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Effects of Self-Efficacy and Response Efficacy Messages in Health News: Changing Health Attitudes and Behavioral Intentions
… with behavior changes such as the adoption of healthier lifestyles. One way that individuals learn about cancer is through the news media. Of all of the sources of health information available to consumers, news media rank among the most accessible and trusted sources; however, little is known …
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Grape Seed Extract as an Adjunct for Modulating Colon Carcinogenesis
Colon cancer is one of the leading causes of cancer deaths in the United States and increasing in incidence globally. Grape seed extract (GSE) is a nutritional supplement with claims as a chemopreventive compound. Preliminary experimental data suggests that dietary GSE may be protective against …
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The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion
In addition to exploring the clinical utility of combination cytokine therapies for the treatment of cancer, our studies also investigate the molecular mechanisms which participate in the generation of peripheral CD8+CD25 + T regulatory cells. Our findings suggest that in the presence of high …
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Absolute Dose Verification in Intensity Modulated Radiation Fields
This work is to device a method for measuring the absolute dose for Intensity modulated radiation fields. An accurate verification and physical measurement of the computed absolute dose in Intensity modulated radiation therapy (IMRT) is a challenging task. There are many sources of errors …
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Experimental and Computational Study of Bisphosphonates Targeting Isoprenoid Biosynthesis Pathway
Bisphosphonates are a class of drugs widely used to treat bone resorption diseases. Recently, bisphosphonates have been found to have anti-cancer, anti-parasitic, anti-bacterial and herbicidal activity. They also have the unexpected property of activating human gammadelta T cells to kill tumor …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
The mechanism employed by DNA tumor viruses to inhibit p53-dependent transcription is poorly understood. Here we describe a new paradigm for human papillomavirus (HPV) E6 oncoprotein-mediated repression of human p21 WAF1 cyclin-dependent kinase inhibitor gene transcription, independent of its well …
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Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds That Induce G1 Cell Cycle Arrest
Great strides are being made in understanding the signaling pathways involved in initiation and growth of cancers, as well as their abilities to evade treatment. Some of this research is being driven by the development of new chemotherapeutics. Accordingly, there is a broadening spectrum of …
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
In chapter two, the ability of CTL 2C to recognize thiol-modified peptide variants is analyzed. A method for the synthesis and screening of thiol-modified peptides that are recognized by T cells is presented. Chapter three continues the peptide variant approach with examination of the ability of …
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The Effects of Soy and Soy Derived Components on the Growth of Estrogen -Dependent Breast Cancer Tumors
The purpose of the studies presented here was to determine if: (1) the chemical form of genistein affects its ability to stimulate the growth of estrogen-dependent breast cancer tumors, (2) the matrix of the food in which the isoflavone is consumed influences its activity in vivo, and (3) genistein …
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The Influence of Diet on Human Breast Parenchymal Densities
Breast cancer is a major public health problem and a leading cause of cancer-related death among American women. Environmental factors, which include diet and nutrition, have been shown to contribute to the increased rates of cancer of the breast as well as other organ systems. The present project …
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Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
Tumor growth suppression was associated with reduced proliferation and increased apoptosis, as quantified by Proliferating Cell Nuclear Antigen (PCNA) immunohistochemistry and the ApoptagRTM assay, respectively. Utilizing real time polymerase chain reactions (RT-PCR) and the SYBR Green assay, mRNA …
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Lycopene, Selenium, Vitamin E and Prostate Cancer
Epidemiologic studies suggest that tomato and lycopene consumption and serum lycopene concentrations are inversely related to prostate cancer occurrence. The oldest, and possibly most cited potential mechanism of action, is that lycopene increases gap junction communication by increasing connexin …
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The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables
In a final study, CHB was found to mediate a monofunctional DNA-directed increase in GST subunit Ya$\sb2,$ Yc$\sb2$ and QR mRNA levels, without a concomitant increase in mRNA levels of CYP 1A. This suggests that, in the previous study, the protection afforded against aflatoxin-induced …
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Cancer Chemoprevention by Vaccinium and Vitis Extracts
In summary, the present studies suggest that specific fractions of both Vaccinium and Vitis species possess considerable anticancer activity. The exact compounds responsible for these activities and their specific mechanisms of action warrant further investigation as potential cancer …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
Curcumin is a beta-diketone constituent of the spice turmeric that possesses anticarcinogenic properties in several animal models. However, the effectiveness of curcumin to act as an inhibitor of mammary carcinogenesis needs further attention. The present studies were conducted in order to evaluate …
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Testosterone, Lycopene Isomers, and Prostate Cancer
The objective of the final study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex …
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Synthesis and Biological Evaluation of Coactivator Binding Inhibitors and Bivalent Ligands for the Estrogen Receptor
The synthesis of steroidal bivalent ligands for ER is also reported. Two estradiol molecules were connected through a phenylethynyl linkage with chemical tethers of varying composition and length. The binding properties of the bivalent ligands for ER were measured. Moderate relative binding …
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Design and Synthesis of Estrogen Receptor Coactivator Binding Inhibitors
Key hydrophobic and hydrogen bonding moieties were incorporated onto a variety of core scaffolds including amphipathic benzene, bicyclo[2.2.2]octane, and urea, resulting in three different series of compounds that could be utilized as coactivator binding inhibitors (CBIs). A fluorescence-based …
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