Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"Health Sciences, Immunology."”.
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STUDIES ON THE OPSONIZATION OF STREPTOCOCCUS PNEUMONIAE BY HUMAN C-REACTIVE PROTEIN.
STUDIES ON THE OPSONIZATION OF STREPTOCOCCUS PNEUMONIAE BY HUMAN C-REACTIVE PROTEIN.
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Distinct isotype-specific factors for immunoglobulin class switch recombination.
Distinct isotype-specific factors for immunoglobulin class switch recombination.
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TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
Antiphospholipid antibodies (APAs) are detected in various autoimmune diseases, such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
Most conventional vaccines are administered parenterally (e.g., by intramuscular (IM) or intradermal (ID) injection) and induce systemic but rarely mucosal immunity. Novel vaccination strategies capable of inducing both systemic and mucosal immune responses could greatly reduce infection and …
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IL-23 and IL-27 expression in dendritic cells and the effects of HIV-1
Dendritic cells (DCs) are potent antigen presenting cells whose role in eliciting immune responses in the context of human immunodeficiency virus type-1 (HIV-1) infection remains unclear. The objective of this project was to determine if HIV-1 modulates DC function by downregulating the production …
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The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection
<p>The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent of CD4 T cells, but it is not clear why some primary, pathogen-specific CD8 T …
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Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy
Immuno-gene therapy is a promising approach for the control of cancer. Because of the essential role in activating and expanding T cell responses to antigens, cytokines are comprehensively studied for cancer therapy. The efficacy of cancer immunotherapy is diminished by the fact that spontaneous …
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Macrophage Activation Profile and Phenotype Are Regulated by Metabolic Pathways and Are Altered by Diabetic Conditions
The incidence of type 2 diabetes is rapidly expanding. Some of the more obvious pathologies associated with it include: defective glucose metabolism, obesity, cardiovascular disease and an inability to mount an effective immune response to infection by certain pathogenic organisms, leading to …
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Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis
We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are …
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Genetic Control of Experimentally Induced Reproductive Autoimmune Phenotypes
Additional studies identified phenotypic-specific effects of QTL on AOD. Interaction analysis showed that multiple loci may affect a particular phenotype including loci linked to other phenotypes and suggested that some genes may be important only to a single phenotype while others may affect …
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Pseudorabies Virus Infection of Porcine Peripheral Blood Leukocytes
Pseudorabies virus (PRV) is an alphaherpesvirus of swine that causes significant morbidity in adult populations, morbidity and mortality in young pigs, and economic losses to the swine industry each year. Evidence suggests that PRV causes immunosuppression in infected swine with resultant risk of …
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Biochemical and Molecular Characterizations of a Novel DNA Repair Enzyme, CPD -Photolyase, and Late Promoters of Fowlpox Virus
To further exploit FPV as a vector, characterization of strong promoters were attempted using a lacZ gene based reporter assay. The transcriptional element of ORF P190 appeared to be the strongest. In contrast, the promoter associated with the ORF, P180, was the weakest. Interestingly, a novel …
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The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
Use of soy-based infant formulas has aroused concern due to potential estrogenic effects of the soy isoflavones genistein and daidzein. Here we show that subcutaneous genistein injections in ovariectomized adult mice produced dose-responsive decreases in thymic weight of up to 80%. Genistein's …
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Antibody Response to Lipopolysaccharide of Salmonella Typhimurium
This differential mAb recognition of O-Ag had a direct correlation with the differential level of protection mediated by individual mAbs in mice challenged with virulent S. typhimurium. Therefore, a subtle modification of O-Ag such as acetylation has a profound effect on the host immune response.
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Structure, Function and Engineering of Peptide -Mhc Binding Receptors
In chapter 5, a T cell receptor interaction with its peptide-MHC ligand was explored using various TCR mutants engineered by yeast display. Previous work in the lab showed that mutations in the CDR3 regions of the TCR could generate higher-affinity, peptide-specific TCR variants. In contrast, other …
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Engineering T Cell Receptors to Examine the Role of Affinity and *Kinetics in T Helper Cell Function
Chapter five details the engineering of a class II restricted human TCR isolated from a patient with multiple sclerosis called 3A6. Yeast display of TCRs has previously relied on the use of an antibody specific for a properly folded TCR, here various strategies were used to generate stabilized 3A6 …
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Engineering Soluble, High Affinity Receptor Antagonists for Bacterial Exotoxins
Chapter four describes the engineering of murine Vbeta8.2 for picomolar affinity to staphylococcal enterotoxin B (SEB). As the known contact regions had already been heavily mutagenized, additional engineering of the Vbeta was performed through extension of the CDR1 loop. Soluble forms of the …
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Regulatory Mechanisms Controlling Expression of the Toll-Like Receptor 2 Subfamily
Therefore, this thesis describes three novel mechanisms controlling expression of TLR2 subfamily members---one acting at the level of transcriptional activation, another at the post-transcriptional level, and finally one that regulates the post-translational localization of the receptor. In chapter …
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Effects of Secondary Forces on the Primary Interaction and Variable Domain Conformation of Antifluorescein Antibodies
Secondary forces are biochemical interactions that occur between regions surrounding the mouth of the antibody active site and the environment of homologous ligand or epitope. These interactions have been demonstrated to modulate the antibody variable domains as well as impacting complex stability. …
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