Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 295 for “"Head and neck"”.
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Vegetable intake and head and neck cancer
Introduction: Head and neck cancer (HNC), especially cancers of the oral cavity, oropharynx, hypopharynx, and larynx is the sixth most common cancer, affecting more than half a million patients worldwide and approximately 4% of patients in the United States, with a five-year survival rate of 60% …
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Prognostic biomarkers for head and neck squamous carcinoma
Head and neck cancer is the 6th most common cancer and is generally treated with surgery and post surgical radiotherapy (RT) alone or in combination with chemotherapy (CT). Over 50% of the patients fail to respond to such treatment while suffering the undesirable side effects of radio-chemotherapy. …
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Genetic Alterations in Advanced Head and Neck Cancer
… neoplasms. In squamous cell carcinoma of the head and neck (SCCHN) loss of heterozygosity (LOH) at 10q has been described to be associated with poor prognosis. Moreover, genetic instability of microsatellite repeat sequences (MI) seems to concur with PTEN mutation in endometrial and colorectal …
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HPV and p16 in head and neck cancer
… papilloma virus (HPV) may play a causal role in head and neck carcinoma (HNSCC). The aim of this study was to investigate the prevalence of HPV DNA in HNSCC and to determine whether any correlation exists with p16 or survival. An initial pilot study of sixty formalin-fixed HNSCC was carried out …
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Age-associated alterations in head and neck cancer
Head and neck squamous cell carcinomas (HNSCC) are the seventh most common cancers globally and have poor survival rates. Current first-line treatments for HNSCC, which include surgical resection and radiotherapy, result in high post-treatment morbidity while alternative treatment modalities, such …
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Gene expression analysis of head and neck cancer development
Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. …
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Multi-atlas segmentation in head and neck CT scans
… automating the task of segmenting structures in head and neck CT scans, to minimize time spent on manual contouring of structures of interest. We focus on the brainstem and left and right parotids. To generate contours for an unlabeled image, we employ an atlas of labeled training images. We …
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Impact Biomechanics of the Head and Neck in Football
… in the thesis explores the biomechanics of the head and neck during impacts in football. The research related to the head is geared towards advancing the current understanding of the mechanisms of mild traumatic brain injury, specifically by investigating head accelerations experienced by …
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The effectiveness of fibrin sealants in head and neck surgery
… sealants as adjuncts in haemostasis during head and neck surgery has garnered increasing attention, yet their clinical efficacy remains a subject of debate. This thesis evaluates the effectiveness of fibrin sealants in patients undergoing head and neck surgery through a systematic review and …
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Targeted Differentiation of Primary Head and Neck Squamous Cell Carcinoma Cells
Head and neck squamous cell carcinoma (HNSCC) is a malignant disease; it is the fourth most common cancer in Germany and the sixth most common cancer worldwide, with high fatality rates that have remained essentially unchanged for many years. Especially in the subtype that is negative for human …
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Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
… CYOTOXICTY IN <em>CREBBP</em>/<em>EP300</em>mut HEAD AND NECK SQUAMOUS CELL CARCINOMA</strong></p> <p>Thomaia Pamplin</p> <p>Advisor: Curtis Pickering, Ph.D.</p> <p>Background: Head and neck squamous cell carcinoma HNSCC is the most common malignancy in the head and neck. Most cases are found in …
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Tp53 As A Biomarker In Head and Neck Squamous Cell Carcinoma
… that guide treatment decisions for patients with head and neck squamous cell carcinoma (HNSCC). Several retrospective studies have evaluated TP53 in HNSCC, and results have suggested that specific mutations are associated with poor outcome. However, there exists heterogeneity among these studies …
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Quantitative Imaging For Precision Medicine In Head and Neck Cancer Patients
… models using quantitative imaging measures in head and neck squamous cell carcinoma (HNSCC) patients could be improved when noise due to imaging was reduced. This was investigated separately for salivary gland function using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), …
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Implementation of Upright Treatments For Lung and Head and Neck Cancers
… upright position such as better patient comfort and increased total lung volume with reduced lung motion. The purpose of this study was to investigate the feasibility of implementing upright treatments for lung and H&N cancers. Several clinical aspects were examined, including radiation shielding …
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Molecular mecanisms involved in the pathogenesis of head and neck paragangliomas
Los paragangliomas abdominales y feocromocitomas (PGLs/PCCs) y los pargangliomas de cabeza y cuello (HNPGLs) son tumores que surgen, respectivamente, de los paraganglios (PG) simpáticos y parasimpáticos. Son tumores raros, generalmente benignos con una incidencia de 1:1.000.000 de habitantes por …
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Genetic analysis of squamous cell carcinoma of the head and neck
Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide with an increasing incidence in developing countries. Despite numerous advances in surgery, radiotherapy and chemotherapy over the past few decades the overall survival rate for patients with HNSCC has changed …
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Targeting head and neck squamous cell carcinoma through NQO1-mediated cytotoxicity
Head and neck squamous cell carcinomas (HNSCC) are a group of anatomically diverse cancers characterized by their resistance to traditional chemotherapy and radiotherapy modalities. Given that as diagnostic and therapeutic strategies in cancer treatment have seen great improvements over the last …
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INTEGRATION OF REDOX-REGULATED SIGNALING AND METABOLISM IN HEAD AND NECK CANCER
Head and Neck Squamous Cell Carcinoma (HNSCC) is a complex disease characterized by genetic and metabolic changes. Radiation therapy alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Resistance to …
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THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinomas (HNSCC) are among the leading causes of cancer related deaths throughout the world. The survival rate for this type of cancer is extremely low and has not changed significantly in recent decades. There is an imperative need to study tumor progression in a …
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