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Showing 1 to 20 of 121 for “"Head and Neck Cancer"”.
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Vegetable intake and head and neck cancer
Introduction: Head and neck cancer (HNC), especially cancers of the oral cavity, oropharynx, hypopharynx, and larynx is the sixth most common cancer, affecting more than half a million patients worldwide and approximately 4% of patients in the United States, with a five-year survival rate of 60% …
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Genetic Alterations in Advanced Head and Neck Cancer
… neoplasms. In squamous cell carcinoma of the head and neck (SCCHN) loss of heterozygosity (LOH) at 10q has been described to be associated with poor prognosis. Moreover, genetic instability of microsatellite repeat sequences (MI) seems to concur with PTEN mutation in endometrial and colorectal …
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HPV and p16 in head and neck cancer
… papilloma virus (HPV) may play a causal role in head and neck carcinoma (HNSCC). The aim of this study was to investigate the prevalence of HPV DNA in HNSCC and to determine whether any correlation exists with p16 or survival. An initial pilot study of sixty formalin-fixed HNSCC was carried out …
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Age-associated alterations in head and neck cancer
Head and neck squamous cell carcinomas (HNSCC) are the seventh most common cancers globally and have poor survival rates. Current first-line treatments for HNSCC, which include surgical resection and radiotherapy, result in high post-treatment morbidity while alternative treatment modalities, such …
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Gene expression analysis of head and neck cancer development
Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. …
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Quantitative Imaging For Precision Medicine In Head and Neck Cancer Patients
… models using quantitative imaging measures in head and neck squamous cell carcinoma (HNSCC) patients could be improved when noise due to imaging was reduced. This was investigated separately for salivary gland function using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), …
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INTEGRATION OF REDOX-REGULATED SIGNALING AND METABOLISM IN HEAD AND NECK CANCER
Head and Neck Squamous Cell Carcinoma (HNSCC) is a complex disease characterized by genetic and metabolic changes. Radiation therapy alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Resistance to …
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Evaluation of telomerase activity and telomerase inhibitors in Head and Neck cancer
Cancer is a major cause of morbidity and mortality with increasing incidence worldwide. Early detection of cancers and better treatments would improve the outcome for patients. The overall 5-year survival rates of head and neck squamous cell carcinoma have not improved in the past several decades …
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Salivary analysis in dogs undergoing definitive radiation therapy for head and neck cancer
… the most common side effects of radiotherapy of head and neck tumors (HNT) in people and can significantly impact a patient's quality of life post-treatment. Aside from causing dry mouth, this condition may affect chewing, swallowing, and oral health. There are numerous diagnostic tools that have …
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Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells
… quantitative PCR, western blot analysis, and immunostaining. Furthermore, EGF and TGF-β, growth factors that induce migration and invasion of HN12 cells, produced synergistic increases in vimentin expression. To assess the contribution of vimentin to the biological properties, HN12 cells …
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The Effect of Shoulder Variation On Imrt and Smartarc For Head and Neck Cancer
… </strong>First, to determine an average and maximum displacement of the shoulder relative to isocenter over the course of treatment. Second, to establish the dosimetric effect of shoulder displacements relative to correct isocenter alignment on the dose delivered to the target and the …
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Integration of Biomedical Imaging and Translational Approaches For Management of Head and Neck Cancer
… with radiotherapy (RT) platforms for monitoring and adaptation of radiation dose, prediction of tumor response and disease outcomes, and characterization of patterns of failure and normal tissue toxicity in head and neck cancer (HNC) patients with potentially curable tumors. In Aim 1, we showed …
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Methods for the Prediction of Osteoradionecrosis resulting from Head and Neck Cancer Radiation Therapy
<p>Head and neck cancer (HNC) is the sixth most diagnosed cancer worldwide with over 600,000 patients diagnosed every year. One of the primary methods to treat HNC is through radiation therapy (RT). While RT is effective at treating HNC, late toxicities resulting from treatment can occur months to …
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Robust Treatment Planning and Robustness Evaluation for Proton Therapy of Head and Neck Cancer
Intensity modulated proton therapy (IMPT) in head and neck squamous cell carcinoma (HNSCC) offers superior advantages over conventional photon therapy, by generating high conformal doses to the target volume and improved sparing of the organ at risks (OARs). Besides, robust treatment planning …
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PET in the evaluation of head and neck cancer treatment - management of the neck
The treatment for head and neck squamous cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour …
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The Rad51 family of proteins: Interactions, vitamin D, and implications in head and neck cancer
… from carcinogenic consequences of DNA double-strand breaks (DSBs) is accomplished through the pathways of non-homologous end-joining (NHEJ) or homologous recombinational repair. Five human proteins with homology to Rad51 known as the Rad51 paralogs, Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3, whose …
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Late-Effect Symptoms, Tobacco and Alcohol Use, and Demoralization in Head and Neck Cancer Survivors
Worldwide, head and neck cancers are the sixth most common type of cancer and comprise the ninth most common forms of cancer in the United States. Estimates of U.S. adults diagnosed with head and neck cancer in 2017 exceeded 53,000. Head and neck cancers are located in areas of the body associated …
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The Lived Experience of Recovery Following Transoral Robotic Surgery (TORS) for Head and Neck Cancer
… surgery (TORS), has enabled select patients with head and neck cancer to receive treatment that results in less disfigurement and dysfunction compared with traditional approaches. While TORS research has focused mainly on functional surgical outcomes, a need exists to understand recovery following …
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The effect of deprivation and comorbidity on survival in patients with head and neck cancer
… Research suggests that patients with head and neck cancer from poorer backgrounds are more likely to have recurrences or die earlier than similar patients from affluent backgrounds. Survival is influenced by tumour characteristics on presentation and a range of individual factors such …
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