Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Hdac4"”.
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
… IIa histone deacetylase (HDAC), which include HDAC4, 5, 7 and 9 are regulators of osteoclastogenesis. Evidence from our lab and other labs using in vitro cell culture and in vivo mouse model systems indicated that HDAC7 and 9 are negative regulators of osteoclast differentiation and activity. …
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Expression of Capn6 During Osteoclast Differentiation In Wild-Type and Hdac4 Knockout Mice
… not much is known about the specific role of HDAC4. Capn6 has been linked to increased organization of osteoclast microtubules for bone resorption. In this study, we observe the expression of Capn6 in wild-type and HDAC4 knockout osteoclasts. Methods: qRT-PCR was preformed to assess Capn6 …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… the reported miR-1 target in skeletal muscle-HDAC4, and separately, a myogenic factor that is reportedly inhibited by HDACs-follistatin. Anti-miR-1 LNA dampens follistatin mRNA level, which is rescued by HDAC inhibitor trichostatin A (TSA). Concurrently, anti-miR-1 LNA also inhibits myotube …
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EXPRESSION OF HISTONE DEACETYLASE 4 AND HISTONE ACETYLTRANSFERASE 4 IN HUMAN MASSETER MUSCLE: RELATIONS TO FIBER-TYPE COMPOSITION IN PATIENTS WITH MALOCCLUSIONS
… modifying enzymes histone deacetylase-4 (HDAC4) and histone acetyltransferase-4 (MYST4) and expression of myosin heavy chain (MyHC) genes and fiber-type percent occupancy (%Occ) in masseter muscle of patients undergoing orthognathic surgery to correct severe dentofacial malocclusions. The …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… potent inhibitor of bone formation) by inducing HDAC4/5 nuclear translocation and MEF2C inhibition. Recently, Scriptaid, an HDAC complex inhibitor, has been shown to induce Mef2 expression and exercise-like adaptation in mouse muscles. In myocytes, Scriptaid disrupts the HDACs co-repressor …
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IDENTIFICATION OF LOCI CONTRIBUTING TO THE SMITH-MAGENIS SYNDROME-LIKE PHENOTYPE AND MOLECULAR EVALUATION OF THE RETINOIC ACID INDUCED 1 GENE
… to one gene: the histone deacetylase 4 gene (HDAC4). Using both clinical and molecular clues, we were able to identify one subject from our SMS-like cohort who has an insertion in HDAC4 which results in a premature stop codon. We conclude from this study that mutation of HDAC4 results in …
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Classical And Ab Initio Qm/mm Simulations Of Bacterial Enzymes
… tested as potential radiotracers, onto HDAC4 and HDAC8 enzymes to calculate/compare their relative binding affinities. The trends in the increase in affinity, of the novel substrates for HDAC4 and HDAC8 active sites calculated by molecular docking, agreed with the experimentally shown …
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Regulation of Skeletal Muscle Innervation and ALS Pathogenesis by MicroRNA 206
… repressive influence on histone deacetylase 4 (HDAC4). I also explored another function of miR-206, as an essential modulator of retrograde growth factor signaling during the progression of neurodegenerative disease. By crossing miR-206 mutant mice to G93A-SOD1 transgenic mice, which express a …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… in adipocytes, through their action on HDAC4, CRTC2 and CRTC3, and potentially also other transcriptional regulators. We also identified PP2A as an interacting partner of SIK2 in adipocytes and future studies will further evaluate the importance and function of this interaction. In …
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Regulation of skeletal myogenesis by the mTOR signaling network
… is delineated, in which miR-1 suppression of HDAC4 results in production of follistatin and subsequent myocyte fusion. Collective evidence strongly suggests that follistatin is the longsought mTOR-regulated fusion factor. In summary, these findings unravel yet another link between mTOR and …
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Identification of novel protein kinase regulators of TGFβ signalling
… and the class IIa histone deacetylases (HDACs) HDAC4 and HDAC5. From the research conducted during this thesis project, it is now evident that SIKs also function to modulate TGFβ-dependent transcriptional responses. However, the precise molecular mechanisms underlying this observation remain to …
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
… significantly reduced CRTC2, CRTC3 and HDAC4 phosphorylation and robustly increased gluconeogenic gene expression and glucose production. The effects of HG-9-91-01 on hepatic gluconeogenesis were validated as SIK-specific, using HG-9-91-01-resistant SIK mutants, LKB1-null hepatocytes …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… the neuroprotective potential of the selective HDAC4/5 inhibitor, LMK235. We showed that LMK235 promotes neurite outgrowth and protects against 6-OHDA-induced neurite injury in SH-SY5Y cells and promotes increases in neuronal length and branching in cultured rat ventral mesencephalic DA neurons …