Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Hcp1"”.
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Construction, characterization, and evaluation of CLH001 as a vaccine candidate against respiratory glanders
… constructed and characterized B. mallei ∆tonB ∆hcp1 (CLH001), a strain deficient in iron uptake and type six secretion functions, and investigated its ability to protect against acute respiratory glanders infection. When compared to wild-type (wt), CLH001 exhibited decreased growth kinetics in …
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Identification and Characterization of Novel Melioidosis Vaccine Candidates
… pseudomallei hemolysin co-regulated protein 1 (Hcp1) with a capsular polysaccharide-based glycoconjugate (CPS-CRM197) could be used to immunize C57BL/6 mice against a lethal inhalation challenge with B. pseudomallei. Additionally, we showed that 100% of the vaccinated mice survived for 35 days …
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
… cell death. Using two mutant strains, ∆bicA and ∆hcp1, as case studies, we demonstrate that there is a differential macrophage polarization and apoptosis response. Together, they represent host response elements that are manipulated by the bacteria in a secretion system dependent manner to promote …
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Dissecting the puncturing device of the Type VI Secretion System: role of Hcp, VgrG and PAAR proteins in assembly and secretion of effectors
… of different effectors. It was found that Hcp1 is essential to maintain T6SS–mediated antibacterial activity. Conversely, Hcp2 and Hcp3 seem to be dispensable for T6SS function. Next, it was found that S. marcescens can use either of the VgrG homologues to form a functional T6SS, albeit not …