Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hb9"”.
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… factors including Olig2, Ngn2, Islet1 and Hb9.\r\nvi.\r\nWe also found that the motoneuron determinant, Hb9, was induced in hNSCs in bFGF-dose and time-dependent manner and that blockade of bFGF signaling reduced Hb9 expression. Furthermore, bFGF treatment did not significantly enhance cell …
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Transcriptional Regulation of Neuronal Differentiation in the Drosophila Central Nervous System
… via cross-repressive interactions with Eve and Hb9, which are expressed in the sibling motor neurons. In chapter 3, I detail the identification of FoxD, a transcription factor that is positively regulated by the homeodomain-containing transcription factor Hb9 in the Drosophila CNS. FoxD is …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… LIM-HD activity. Motor neurons fluoresce in HB9:GFP transgenic zebrafish as the promoter of the motor neuron specific gene Hb9 drives expression of GFP. Motor axons in DN-CLIM injected HB9:GFP zebrafish are unable to exit the spinal cord, instead they grow inside the spinal cord. Thus axon …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… cells. As expected motor neuron markers (Hb9, ChAT) as well as a dopaminergic neuron marker (TH) were upregulated in neuronal cells derived from P19/Shh. Collectively, these results suggest that Shh may have multiple functions in neural induction of uncommitted stem cells, proliferation of …
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Characterization of spontaneous and evoked activity of mouse embryonic stem cell derived motor neurons using optogenetics and micro electrode array electrophysiology
… expression of eGFP with a MN specific promoter, Hb9. The mES cell line was transfected with channelrhodopsin-2 (ChR2) tagged with Td-Tomato which allowed for optogenetic stimulation of the networks with a 470 nm LED. Network firing patterns were evaluated for bursting activity and spectral …
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Biofabrication of muscular and neuronal in-vitro tissue for multi-cellular engineered living systems
… transfected to express a GFP reporter under the Hb9 promoter as well as Channelrhodopsin, to enable optogenetic stimulation of these neurons, which was used to design the training regimens. Past efforts have not considered reprogramming in terms of evoking long-term changes in firing patterns of …