Global ETD Search
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Showing 1 to 2 of 2 for “"Hash-1"”.
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Notch Signaling in Human Neuroblastoma Cells
… during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. Hash-1 is a component of the Notch signaling cascade, which is involved in many cell fate decisions. In general, Notch activity maintains a pool of undifferentiated cells and dysregulated Notch …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… such as the SNS-specifying transcription factors HASH-1 and dHAND. Hypoxic up-regulation of ID2 was dependent on direct in vivo DNA-binding and activity of hypoxia-inducible factors (HIF), the master transcriptional regulators of oxygen homeostasis. Induction of ID2 expression occurs as an early …