Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 174 for “"Harvard--MIT Program in Health Sciences and Technology."”.
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The use of strong personal media in the context of chronic disease treatment : music as a mediator of depression and pain experience
Thesis (Ph. D.)--Harvard-MIT Program in Health Sciences and Technology, 2013.
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Neural mechanisms underlying core visual perception of objects
… of objects is a computationally challenging problem and fundamental to human well-being. Extensive previous research has revealed that the inferior temporal cortex (IT), a high-level visual area, is involved in various aspects of visual perception. Yet, little is known about: how IT …
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Assessment of the appropriateness and market opportunity of a point-of-care diagnostic solution for hepatitis C in the United States
Hepatitis C (HCV) is the most common bloodborne infection in the United States. Although the incidence of HCV is declining, the burden of the disease is rising, driven by the increasing rates of end-stage liver disease and other consequences of advanced HCV infection. According to a 2009 report, …
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Phonological working memory and finiteness marking in typical development
… language functions: phonological working memory (PWM) as indexed on nonword repetition (NWR) tasks, and finiteness-related grammatical processing, as indexed by grammaticality judgment. These fundamental language abilities make particularly alluring candidates for investigation due to …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
Cancer is one of leading cause of deaths, and responsible for 8.2 million deaths worldwide. Especially, 70% of deaths from cancer occur in low or mid income countries. In order to deliver affordable and accessible cancer care to low income developing countries, it is critical to develop rapid, low …
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Understanding vertebral fracture risk in astronauts
In spaceflight, the loss of mechanical loading has detrimental effects on the musculoskeletal system. These muscular changes will likely affect spinal loading, a key aspect of vertebral fracture risk, but no prior studies have examined how spinal loading is affected by long duration spaceflight. …
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Evaluation of teledermatology in the Veterans Health Administration
Telehealth technologies are being employed to increase access, quality of care, and cost containment. However, there are no widely accepted measures of telehealth performance and little information about long-term changes in access. The Veterans Health Administration (VHA) is advantageous for …
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Nanoporous elements in microfluidics for multi-scale separation of bioparticles
The efficient isolation of specific bioparticles in lab-on-a-chip platforms is important for many applications in clinical diagnostics and biomedical research. The majority of microfluidic devices designed for specific particle isolation are constructed of solid materials such as silicon, glass, or …
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Cochlear hair cell regeneration from neonatal mouse supporting cells
… regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought to lack any spontaneous regenerative potential. …
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Neural and perceptual correlates of closed-loop sensorimotor training: basic and applied studies
The global hearing healthcare field is faced with two principal challenges. First, the demand for basic audiometric testing services far exceeds the capacity of trained clinicians even in high income countries, and this supply/demand mismatch is expected to worsen secondary to population aging. …
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Engineering arterial substitutes that recapitulate vessel microstructure and mimic native physiological responses
Engineering small caliber (< 6mm) arterial grafts remains an unsolved problem. Current synthetic and autologous grafts suffer from short and long-term limitations including decreased patency rates, risk of bacterial infection, and compliance mismatching that results in neointimal hyperplasia. …
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Ultrasonic imaging methods for quantitative musculoskeletal tissue assessment and improved prosthetic interface design
For persons living with lower extremity amputation, the prosthetic socket -- the cup-like interface connecting the residuum to prosthesis - is considered the most critical component. It must be custom-made and tailored to each individual user, and if not fit properly can significantly hinder …
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Methods and devices for noninvasive physiologic fluid volume assessment
… tool. Volume control becomes an issue during sickness and/or stress (physical and mental) in a wide range of populations. Unfortunately, current diagnostics suffer from being imprecise, invasive, and/or easily confounded and cannot unambiguously and practically inform volume status. There …
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MR-assisted PET data optimization for simultaneous dual-modality imaging in dementia
Recent advances have allowed the hardware integration of positron emission tomography (PET) and magnetic resonance imaging (MRI). The spatiotemporally correlated data acquisition opened up opportunities for numerous applications. Furthermore, the MRI data can be utilized to improve the PET scanner …
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Compact tomographic X-ray phase-contrast imaging of breast cancer
Non-invasive imaging plays an important role throughout the clinical diagnosis and management process of breast cancer. Unfortunately, existing imaging methods lack the combination of spatial resolution and soft-tissue contrast necessary to visualize pathological changes in the breast. X-ray …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
The successes of vaccines in modern medicine diminished the morbidity and mortality of many pathogenic infections. Yet, difficulties remain in improving the immunogenicity of modern subunit vaccines. In addition, isolation of antigen-specific memory B cells that would elucidate the long-term …
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Single-molecule visualization of conformational changes in the SecA ATPase
… for new antibiotics is great as bacterial strains with single and multiple drug resistance have continued to grow more prevalent since the 1980's. At the same time, the rate of approval of new antibiotics has dropped precipitously. Existing antibiotics commonly target the bacterial ribosome. A …
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Automated, highly scalable RNA-seq analysis
RNA-sequencing is a sensitive method for inferring gene expression and provides additional information regarding splice variants, polymorphisms and novel genes and isoforms. Using this extra information greatly increases the complexity of an analysis and prevents novice investigators from analyzing …
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Engineered approaches to querying the microenvironment of cancer metastasis
Cancer metastasis is the underlying mechanism of 90% of cancer-related deaths, yet few therapeutics exist that directly target it. Part of this scarcity is attributable to a general lack of knowledge with regards to the underlying mechanisms that mediate traversal of the sequential steps required …
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Evidence of inner-ear mechanisms in bone conduction in chinchillas
… of how airborne sound is conducted to the inner-ear via the outer ear and middle ear, so-called air conduction (AC), the mechanisms by which vibrations of the head and body, so-called bone conduction (BC), produce an auditory response are not well understood. It is clear that the inner ear …
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