Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 394 for “"Harvard University--MIT Division of Health Sciences and Technology"”.
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Design and development of a multifiber shielded laser catheter system for removal of atherosclerotic plaque
Thesis: Ph. D., Harvard University--MIT Division of Health Sciences and Technology, 1987
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A new class of functions for describing logical structures in text
Text documents generally contain two forms of structures, logical structures and physical structures. Loosely speaking, logical structures are sections of text that are both visually and semantically distinct. For example, a document may have an "introduction", a "body", and a "conclusion" as its …
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The impact of angel investors on founders of new ventures in the medical technology industry
Founders of new ventures in the medical technology (Medtech) industry require capital to establish, sustain, and grow their companies. Most founders must seek some form of external capital to meet these demands; in Medtech, the most well-known and prestigious of these is venture capital (VC). …
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Computerized Automated Reminder Diabetes System (CARDS) : using web and wireless phone technology to improve diabetes compliance
… a popular communications tool among adolescents and young adults. We have created an automated computer system that provides reminders to check blood sugars by e-mail or text messaging on a cellular phone. The reminder schedule is set on a password-protected web site by the user according to his …
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Testimonials versus informational persuasive messages : the moderating effect of delivery mode and personal involvement
Health communications use factual information or/and personal testimonials to inform and influence individual decisions that enhance health. Increasingly, Web and other computer-based systems are being used to communicate with patients. This study aims to test the relative effectiveness of …
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Assessment of hip fracture risk in astronauts exposed to long-term weightlessness
… lose bone mineral density (BMD) at a mean rate of 1-2 percent per month in weight-bearing areas, approximately 10 times the rate associated with normal ageing. There exists an important need to quantify the fracture risk associated with this loss. Methods: Using computational modeling, the …
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Factors contributing to T cell persistence in a tolerizing tumor environment
Cancer is a leading cause of death worldwide, accounting for at least 10% of all deaths globally. Current therapies for cancer include surgical excision, chemotherapy and immunotherapy. CD8[+] T cells are adaptive immune cells responsible for eradicating tumor cells. However, these T cells can be …
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A systems approach to engineering cancer nanotechnologies
… nanostructures with unique electromagnetic and therapeutic properties. These represent a powerful toolkit of building blocks through which multi-component nanosystems could be constructed. Yet, while biological systems produce higher-order functions through coordinated interactions between …
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Near-infrared emitting quantum dots for cellular and vascular fluorescent labeling in in vivo multiplexed imaging studies
… microscopy allows real-time observation of hematopoietic cells, their stem and progenitor cells and metastatic cancer cells in their native bone marrow (BM) environment. Multiplexing has made possible detailed studies of the BM's microarchitecture, which helps define the niche of these …
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Interfilament interactions in the cytoskeleton : single filament measurements and mechanical consequences
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1999.
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Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis and other disease complications, increasing evidence shows that …
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A MEG investigation of lexical access in aphasia
Aphasia is an acquired impairment of language ability that occurs secondary to brain damage, and auditory comprehension deficits are a defining component of aphasia. At the single-word level, these deficits are thought to arise from impaired phonological processing, semantic representations, or …
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Interactions between anterior thalamus and hippocampus during different behavioral states in the rat by Héctor Penagos.
The anterior thalamus and hippocampus are part of an extended network of brain structures underlying cognitive functions such as episodic memory and spatial navigation. Earlier work in rodents has demonstrated that hippocampal cell ensembles re-express firing profiles associated with previously …
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Gentamicin and FM1-43 enter sensory hair cells through mechanosensory transduction channel
… describes a novel mechanism for the entry of organic cations, including the styryl pyridinium dyes and the notoriously ototo.xic aminoglycoside antibiotic drugs, into sensory hair cells: permeation through the transduction channels. Both gentamicin, an aminoglycoside, and FM1-43, a styryl …
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Pitch perception and harmonic resolvability in normal-hearing and hearing-impaired listeners
Listeners with sensorineural hearing loss are often impaired in their ability to perceive the pitch associated with the fundamental frequency (FO) of complex harmonic sounds. Four studies investigated the relationship between FO discrimination performance and the ability to resolve individual …
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Nuclear magnetic resonance imaging of tumor pathophysiology and angiogenesis
Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2002.
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Processing strategies for functional magnetic resonance imaging data sets
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1999.
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Monaural perception under dichotic conditions
… There are times, however, when the addition of a second ear results in poorer performance (i.e., contra-aural interference). Contra-aural interference is of interest because it is not explained by current auditory models, it has theoretical ramifications, and its understanding could lead to …
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Quantifying the patient population of ultra-orphan diseases: a case study in X-Linked Hypohidrotic Ectodermal Dysplasia
Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of orphan disease is a disorder that must affect less than 200,000 people, or 1 …
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Characterization in cochlea of KCTD12/PFET1, an intronless gene with predominant fetal expression
The prevalence of severe to profound bilateral congenital hearing loss is estimated at 1 in 1000 births, at least half of which can be attributed to a genetic cause. To date, mutations in at least 67 genes have been associated with hearing loss. Discovery of these genes has revealed fundamental …
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