Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Harmine"”.
-
Characterisation of mammalian cytochrome P450 enzymes by their metabolic activities.
… the in vitro transformation of the B-carbolines, harmine and harman. Comparative studies were also carried out with rat liver microsomal P450s, where the effects of induction on the metabolism of harmine were investigated to define which rat P450s contribute to microsomal harmine metabolism. 1) …
-
CYP2D in the Brain Alters Response to Drugs and Neurotoxins
… four-hour inhibitor pretreatment exacerbated harmine-induced hypothermia and tremor in transgenic mice and exacerbated only hypothermia in wild-type mice. A twenty-four-hour inhibitor pretreatment irreversibly inhibited human CYP2D6 in transgenic brain only and was thus used to test the …
-
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… FDA-registered drugs. The neuroactive alkaloid harmine was identified as the most powerful molecule at inducing cardiomyocyte proliferation in vitro and heart regeneration after myocardial infarction in vivo. Harmine exerted its activity through the inhibition of the dual specificity …
-
Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
… a green tea polyphenol. We also confirmed that harmine, a more highly studied and specific Dyrk1a inhibitor, is capable of similar effects on proliferation of PA1 cell from E9.5 Ts65Dn embryos. Furthermore, when Ts65Dn pregnant mothers were treated with EGCG in vivo, the cellular deficit found …