Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 267 for “"Haplotypes"”.
-
Identification of major histocompatibility complex haplotypes in goldfish, Carassius auratus
… segregation of additional sets of phenotypic MHC haplotypes in the tetraploid goldfish. The utility of chicken anti-chicken reagents in serotyping of fish was demonstrated. Use of the traditional approach to conducting hemagglutination assays limited the number of assays executed because of the …
-
XPC Haplotypes Alter DNA Repair Capacity and Levels of Genetic Damage
… is that specific XPC SNP combinations (haplotypes) alter DNA repair capacity and levels of genetic damage by altering transcriptional processes and/or protein function. I used bioinformatics to conduct a comprehensive haplotype analysis of the entire genomic sequence of XPC and …
-
Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes
… to firstly elucidate the common UCH-L1 promoter haplotypes that exist within the population, and secondly, in an attempt to uncover any association between the polymorphic alleles and general neurodegenerative symptoms - no association was uncovered. <br/>Using pGEM-T Easy as an initial ‘holding …
-
Utilizing Haplotypes For Sensitive Snp Array-Based Discovery of Somatic Chromosomal Mutations
<p>Somatic copy-number (CN) gains and losses and copy-neutral loss of heterozygosity (CNLOH) frequently occur in tumors and play a major role in the progression of disease by altering gene dosage and unmasking deleterious recessive variants. Characterizing these mutations in an individual tumor …
-
Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
… understanding the biological forces that shape haplotypes. We have studied a well-characterized genetic locus surrounding the gene responsible for hereditary hemochromatosis (HFE) to investigate the impact of meiotic recombination events upon haplotype structure in this region. First we …
-
Development of A Bayesian Joint Logistic Model to Better Study The Association Between Haplotypes and Disease
… a new statistical method to evaluate the role of haplotypes in cancer susceptibility and development. This model will be flexible enough to handle not only haplotypes of any size, but also a variety of covariates. I will then apply this method to three cancer-related data sets (Hodgkin Disease, …
-
Sickle cell anaemia in Cameroon : co-inheritance of α-thalassemia, HBB gene haplotypes, clinical & haematological characterisations
… for the study of the β-globin (HBB) gene cluster haplotypes. Multiplex Gap-PCR was performed to investigate the 3.7kb and 4.2kb α-thalassemia gene deletions.
-
Genes, haplotypes and physiological traits associated with a chromosome 3B locus for wheat improvement in hot climates
… panel of 808 accessions identified four haplotypes. Haplotype I, the RAC875 allele was over-represented in the CIMMYT germplasm suggesting that the allele may have been selected for yield in a Mexican environment-type. To study the physiological mechanisms under qYDH.3BL control, we …
-
Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… examines the link between high-risk PERK haplotypes and periodontal inflammation, systemic and local immunological activation, and depression in PWH on ART, while also exploring the molecular significance of PERK signaling in HIV-induced inflammation through peripheral and central immune …
-
Efficient haplotyping for families
… family-based haplotyping algorithms. Haplotypes are useful for mapping and identifying genes which cause and contribute to the etiology of human disease, and for analyzing the products of meiosis to locate recombinations, enabling the identification of recombination hotspots and gene …
-
A phylogeographic investigation of the mountain chickadee
… mitochondrial DNA revealed two highly distinct haplotypes. One of these occurred in the Great Basin and extended eastward into Arizona and the Rocky Mountains of Utah. The other occurred in locations west of the Great Basin, including the Sierra-Nevada Mountains and southern California. Patterns …
-
Nested clade analysis of geographic structure in the morphologically variable Themeda triandra in South Africa
… gene regions of the cpDNA were used to find 12 haplotypes found in 11 populations of T. triandra that encompass the species large distributional range. A haplotype tree was constructed that showed the relationship of the 11 haplotypes (haplotype_H12 was excluded as it fell outside of the 95% …
-
An HMM-based boundary-flexible model of human haplotype variation
… are flawed, however: they arbitrarily sever all haplotypes at block boundaries and assume that block boundaries are areas of free recombination. In reality, haplotypes break up when they recombine, and many past recombination events are predicted to occur at sites of occasional recombination. …
-
Molecular epidemiology of haemoglobin in the population of Libya and the molecular biology of normal and abnormal globin gene expression
… of β-thalassaemia of 0.5%. Eighteen different haplotypes have been found with polymorphic sites associated with 88 β~A -globin gene bearing chromosomes. Fifteen per cent of these are found in the Mediterranean, 50% in Black Africans and 35% are rare ones. Ten different haplotypes were found, …
-
Detailed investigation of the unstable (CAG) repeat and the immediate surrounding region of the IT15 gene in some South African families with Huntington disease
… around the IT15 gene and to determine how many haplotypes there are in SA. Haplotypes were created by genotyping 6 SNPs in a total of 15 HD families. These families were comprised of seven Caucasian, 6 Mixed Ancestry and two Black African families.
-
Shared Haplotype Length Regression and Its Application
… recent alleles should reside on longer haplotypes compared to random haplotypes not under positive selection. My statistics employs generalized linear models and generalized estimating equations to test for associations between shared haplotype lengths and traits. Due to the possibility …
-
Morphological and molecular analyses for the characterization of Aspalanthus linearis (Fabaceae: rooibos)
… amplify the remaining samples and revealed four haplotypes, with a basal haplotype fixed in both the prostrate form and a single population of the erect form, a unique haplotype fixed in the shrub form, and a mix of two other haplotypes in the remaining erect forms. The congruence between …
-
Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis
… which identified a total of 187 different haplotypes, of which 151 were unique to single individuals. The most commonly observed HVI haplotype was identical to the Cambridge Reference Sequence (CRS). Analysis of 78 HVII sequences (nt73-340) revealed a total of 42 polymorphic sites that …
-
The phylogeography of North American chestnuts and chinquapins (Castanea Mill., Fagaceae)
… Carolina. I identified four main chloroplast haplotypes and found that for three of these haplotypes, leaf morphology is a reliable indicator of haplotype identity. I found that the fourth haplotype is shared among accessions of C. dentata and C pumila, and is also found in trees with …
Page 1 of 14