Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Hammerhead"”.
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Close to the edge : finding the Hammerhead Bar
… Imbedded in the sand on a wind-swept beach, the Hammerhead Bar, designed with intention and shaped by my sensibility, invites both the reader and the next hurricane alike to "Take your best shot!"
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Cellular uptake and biological activity of synthetic hammerhead ribozymes
… of target RNA. The potential use of synthetic hammerhead ribozymes as novel anti-brain tumour agents was investigated in this study. The successful use of synthetic, exogenously administered ribozymes for such applications will require chemical modifications that improve biological stability …
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Influence of the Estimator Selection in Scalloped Hammerhead Shark Stock Assessment
… last decades. Our study assessed the scalloped hammerhead shark population on the western North Atlantic Ocean using Bayesian methods. This approach allowed incorporate diverse types of errors in the surplus production model and compare the influences of different statistical estimators on the …
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Studies of the Catalytic-Metal-Binding Site in the Hammerhead Ribozyme Using the Phosphorothioate Approach
… of Hg2+ with the phosphorothioate sulfur in the hammerhead ribozyme is presented here along with evidence for the unexpected discovery that soft metal ions like Hg 2+ and Mn2+ are capable of catalyzing desulfurization of the phosphorothioate at rates similar to that of ribozyme-catalyzed cleavage.
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Investigating single and multiple species fisheries management: stock status evaluation of hammerhead (Sphyrna spp.) sharks in the western North Atlantic Ocean and Gulf of Mexico
Three hammerhead sharks (Sphyrna spp.) are currently managed as part of the large coastal shark complex in the United States. Including multiple species in an assessment ignores the different stock dynamics of each individual species within the complex due to different life histories. This study …
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Optimization of a fiber optic freshwater DOM sensing device
… fiber spectrofluorometer device known as the "Hammerhead" was developed in the Hemond lab in 2015 and improved in 2016 to measure concentrations of dissolved organic matter in water samples. The Hammerhead operates by detecting fluorescence, absorbance, and scattering of light within the water. …
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Investigating and expanding the functionality of RNA catalysts: Studies of the hepatitis delta virus, the hammerhead, and the aminoacyl-tRNA synthetase-like ribozymes
… the hepatitis delta virus (HDV) ribozyme and the hammerhead ribozyme. Results presented here suggest that divalent metal ions play critical roles in the catalytic mechanisms of both the HDV and the hammerhead ribozymes. In the HDV ribozyme, the result is consistent with an active site Mg2+ being …
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Enhancement of anti-HIV-1 Ribozyme Activities by Rev Binding and Multimerization
<p>To effectively apply hammerhead ribozymes as therapeutic agents it is necessary to co-localize them with the desired target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on <em>env</em> gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the …
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Syntax-based guidance for autonomous aggressive aerobatics in urban environments
… In addition, it presents the design of a hammerhead aerobatic maneuver on the same helicopter, and validates both designs in flight. The proposed guidance architecture integrates a new path-following algorithm with a syntax-based dynamically-reconfigurable automaton to enable autonomous …
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Functional Morphology of the Sphyrnid Shark Cephalofoil: an Assessment of the Hydrodynamic Lift Hypothesis Using Computational Fluid Dynamics
The hammerhead sharks (Family: Sphyrnidae) are all characterized by a conspicuous lateral expansion and dorsoventral flattening of the head forming a structure known as a cephalofoil, however, there is substantial morphological variation within the clade. Many theories have been proposed regarding …
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In Vitro Selection and Characterization of Transition Metal -Dependent DNAzymes and RNAzymes
… and a naturally-occurring RNAzyme system, the hammerhead motif, were also further examined in terms of the diversity of conditions under which RNA cleavage activity is supported."
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Structural and Functional Analysis of Secondary Structure Block to mRNA Utilization
… secondary structure, formed by a cis-targeted hammerhead ribozyme in exon 2 two nucleotides dowstream of the 3' splice site of a yeast ACT-E. <em>coli lacZ fusion</em> gene, virtually abolishes splicing in vivo and inhibits B-galactosidase production. This is the first demonstration of the …
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Reimagining Urban Highway Overpass Infrastructure in the US: Designing for Spatial Quality and Material Quantity
… spaces. It also reimagines reinforced concrete hammerhead pier design using topology optimization to generate more efficient piers caps that would require less material and contain less embodied carbon. The study finds that additional complexity of an optimized result does not correlate to …
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Ribozymes of the RNA World: Investigating Ancient Enzymes through Modern Self-Cleaving Ribozymes.
… strategies used by one such ribozyme, called the hammerhead ribozyme, and uncovered how RNA can utilize tautomerization, divalent metals, and folding to diversify its chemical repertoire. To learn more about the catalytic strategies used by RNA and their biological roles, we developed a method …
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Untersuchungen zur nichtinvasiven Tetrazyklin-abhängigen Kontrolle von Genaktivitäten in vivo
… evaluiert. Dabei wurde zuerst der Einsatz von Hammerhead-Ribozymen untersucht, welche die NR1 mRNA katalytisch spalten und sie damit inaktivieren. Durch zwei verschiedene Selektionsverfahren konnten Hammerhead-Ribozyme identifiziert werden, die zwar in vitro gute Spaltungsaktivitäten und z. T. …
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Ice as a medium for RNA-catalysed RNA synthesis and evolution
… the RNA-catalysed transcription of a catalytic hammerhead ribozyme. This demonstrates the catalytic capabilities of ribozyme polymerases. The R18 ribozyme was also exploited as an analogue of a primordial replicase, to determine replicase behaviour in different reaction environments. Substantial …
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Development of Catalytic RNAs as Potential Anti-HIV-1 Agents
… Two classes of ribozymes that incorporate a "hammerhead" catalytic center were utilized, eotide elements in the viral sequence to provide half of the The first class used nuclcatalytic center. A complementary strand harboring the remaining active site nucleotides was supplied in trans and …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… Lastly, inhibition of the autocatalytic hammerhead ribozyme harboured within the 3’UTR of the Clr-b transcript can abrogate genotoxic stress-induced Clr-b downregulation. In the final chapter, we investigate the effect of oncogenic stress mediated through H-RasV12 on Clr-b expression in …
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Widening of Reinforced Concrete Bridges – Extension of Pier Cap Beams with CFRP Composites
… modeling of quarter-scaled reinforced concrete hammerhead non-prismatic pier cap beams, extended on verges and reinforced with different CFRP systems are presented, followed by development of a practical analytical model. In addition, a column strengthening system, which provides a continuous …
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Spatialised ecosystem modelling to evaluate the influences of marine protected areas and provisioning ecotourism on the foraging and distributional response of top predators from Mossel Bay to Algoa Bay, South Africa
… inshore South-East coast nursery areas (smooth hammerhead, dusky, raggedtooth) and less-transient top predators (humpback dolphin, sevengill shark) evidently received positive indirect benefits of the coastal MPAs, particularly Addo (e.g., sufficient prey availability and remaining in the area …
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