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Showing 1 to 4 of 4 for “"Halolactonization"”.
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Design and Synthesis of Enzyme Activated Irreversible Inactivators for Proteases. Suicide Inactivation of Chymotrypsin
… lactones in modest yields, and a direct halolactonization method which gave the desired halo-enol lactones in very high yields was developed. Several other routes, such as Baeyer-Villiger oxidation of (beta)-halocycloenones and dehydration of (alpha)-haloketone acids were also developed …
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Halo Enol Lactones as Enzyme-Activated Irreversible Inhibitors of Alpha-Chymotrypsin: I. The Effect of Lactone Substitution Pattern. Ii. Alpha - Amino-Functionalized Lactones
… were prepared using a halolactonization reaction to convert the appropriate phenyl-substituted acetylenic acid into the corresponding lactone. The 4-phenyl-tetrahydrofuranone and the 5-phenyl-tetrahydropyranone only proved to be competitive inhibitors, and the …
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ORGANOCATALYTIC HALOFUNCTIONALIZATION OF OLEFINS
… produced encouraging enantioselectivty for halolactonization reactions.
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Selective Synthesis of Trans-fused Lactam-Lactones by Vicinal Difunctionalization of Readily Affordable Allylic Lactams
<p>With intrinsic versatility and an overwhelming presence in natural products, nitrogen- and oxygen-containing heterocycles boast a plethora of medicinal properties. Specifically, lactams and lactones are the respective luminaries of the antibiotic and flavor worlds. However, the synthesis of …