Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Halogen exchange"”.
-
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
… would undergo selective metal-halogen exchange at C-7. Gratifyingly the indole underwent selective metal-halogen exchange at C-7 and subsequent elimination to give exclusively the 6,7-indole aryne which underwent Diels-Alder cycloaddition with cyclopentadiene. To complete the …
-
Exchange reactions of organic halides and organo-silicon compounds with boron tribromide and boron triiodide
… have been investigated. The results show exchange of halogens between the BX3 (X = Br# 1) and the organic halidef exchange of the halogen of the C-X bond being proved. The rates of halogen exchange vary. Reaction of the heavier halides with organo-silicon compounds indicated that the …
-
Part I. Molecular tweezers: Role of preorganization and synthetic progress toward a water soluble tweezer. Part II. Progress towards an empirical approach to carbohydrate recognition
… hydroxide solution followed by a lithium/halogen exchange and addition of dimethoxyacridone chromophores. Tweezers 11-13 have zero, one, and two additional degrees of free rotation, respectively, which lessens the enforced syn cofacial orientation of the diacridine chromophores and the …
-
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
… as well as the others by devising a facile metal-halogen exchange and elimination protocol with o-dihaloindoles. In addition to establishing the existence of these fascinating intermediates via trapping with their furan cycloadducts, we applied them to the successful total synthesis of several …
-
Part I. Computational, theoretical and synthetic studies of the indole arynes and their reactions. Part II. Computational, theoretical, and mechanistic studies of n-vinyltrialkylammonium, n-vinylpyridinium, and n-vinyldiazonium tetrafluoroborate salts.
… for their synthetic versatility utilizing metal-halogen exchange and elimination to generate indole arynes. These short-lived intermediates can then be subject to a regioselective cycloaddition, cross-coupling or other reaction. This approach has been used for the successful total synthesis of …
-
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
… would undergo selective metal-halogen exchange at C-7. The success of this novel step is the cornerstone of this synthesis. Gratifyingly the indole underwent selective metalhalogen exchange at C-7 and subsequent elimination to give exclusively the 6,7-indole aryne which …
-
Applications of spectral management in optoelectronic devices
… to the large surface areas and anion mobility halogen exchange between perovskite nanocrystals of different compositions occurs rapidly, limiting applications. Here, we report significantly reduced halide exchange between chloride and iodide CsPbX3 (X= Cl, I) perovskite nanocrystals. We …
-
Borafluorenes and polyborafluorenes boron doped varients of fluorene
… Boron was incorporated synthetically via lithium halogen exchange and Grignard reaction pathways. Once incorporated, the borafluorene could be polymerized or undergo further functionalization via Yamamoto and Stille coupling reactions. This incorporation of boron into a conjugated system imparted …
-
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
… Both indoles underwent selective metal-halogen exchange at C-7 and subsequent elimination to give the 6,7-indole aryne which underwent Diels-Alder cycloadditions with cyclopentadiene, furan and 2,5-dimethyl furan. These cycloadducts were N-alkylated and then subjected to Grubb’s catalyst …
-
Reaction mechanism of solvated n-BuLi with thiophene in THF: A theoretical and spectroscopic study
… into the reaction mechanism of n-BuLi with mono-halogenated (bromine and chlorine) thiophene in THF. The reaction analysis yielded full characterisation of the reaction energy profiles and stationary points for over twenty unique chemical reaction systems. The reaction study shows that the …
-
Utilisation of halophosphine and aminophosphine ligands in organoruthenium chemistry
… a small scale is described. The observation of halogen exchange between the ruthenium centre and halophosphines is reported and the trendsin 'j(P-F) are described in the two series [RuX 2 (n 6-/>cymene)(PF 3 )] and [RuX 2 (n 6 -/?-cymene)(PF 2 {NMe 2 })].The fourth chapter contains the syntheses …
-
Development of biotin protein ligase inhibitors from Staphylococcus aureus as new antibiotics
… in the ribose-binding pocket of SaBPL. The halogenated benzyl derivatives 3.20, 3.21, 3.23 and 3.24 provided the most potent inhibitors of SaBPL with the respective Kᵢ value of 0.28, 0.6, 0.39 and 1.1 μM. These compounds also inhibited the growth of S. aureus ATCC49775 (MIC = 4 – 16 μg/ml), …