Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Hallmarks of Cancer"”.
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High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin
… ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell …
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Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer
Human breast cancers are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or …
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Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
Changes in cellular metabolism are considered one of the hallmarks of cancer. In 1924, Otto Warburg initially posited that defects in cellular respiration drive tumorigenesis after observing that tumor cells often perform aerobic glycolysis in culture. Since then, multiple studies have demonstrated …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
Cancer treatments often target singular oncoproteins in attempt to block one hallmark of cancer and stop tumor growth and progression. However, although these treatments are often initially effective, many cancer patients develop resistance and experience relapse due to redundant signaling or tumor …
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Multiscale Mathematical Modelling of Cancer Invasion
Invasion of the surrounding tissue is one of the hallmarks of cancer. Solid tumours have a reciprocal relationship with the surrounding microenvironment, a complex tissue composed of extracellular matrix and other multiple distinct cell types. Prote- olytic degradation and remodelling of the …
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Defining the Role of PIM1 in Tumor Angiogenesis
… a serine/threonine kinase that is upregulated in cancer. PIM1 is constitutively active upon translation, so protein levels equate to activity. Researchers have connected PIM1 signaling with pro-survival and pro-proliferative roles; however, little is known about how PIM1 is upregulated in cancer …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
Bladder cancer is the most common malignancy of the urinary tract. However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients …
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Multiscale modelling of cancer invasion: the role of dynamic fibre redistribution and matrix-degrading enzymes in tumour progression
Recognised as one of the hallmarks of cancer, cancer invasion is a complex process involving the secretion of matrix-degrading enzymes that have the ability to degrade the surrounding extracellular matrix (ECM). Combined with cell proliferation and migration, and changes in cell-cell and …
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
Apoptosis is a specialized, active form of cell death that is important in both health and disease. It is responsible for maintaining regulated development and tissue homeostasis and participates in the elimination of aged, damaged, or displaced cells. Apoptosis is also an inherent tumor …
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CD200: A Novel Therapeutic Target for Chronic Lymphocytic Leukemia
The ability of cancer cells to escape anti-tumor immune responses is acknowledged as one of the hallmarks of cancer. Overexpression of immunoregulatory molecules is one mechanism responsible for the immunsuppressive network that is characteristic of the tumor microenvironment. In this thesis, we …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
Despite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated …
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… disease with a 5-year overall survival rate of less than 10%, due to late diagnosis mostly at advanced stages, excluding primary tumor resection as putative curative treatment, early metastasis and profound therapy resistance. A promising target for new therapeutic options is the L1 cell …
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The role of BCLFA1 in cellular transformation
The malignant transformation of normal cells into cancer cells result in the loss of control of cellular regulatory mechanisms such as loss of function of tumour suppressors and gain of function of oncogenes. Genetic mutations may be inherited or acquired during the process of malignant …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. the …
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Computational Methods to Identify and Target Druggable Binding Sites at Protein-Protein Interactions in the Human Proteome
… are fundamental in cell signaling and cancer progression. An increasing prevalent idea in cancer therapy is the development of small molecules to disrupt protein-protein interactions. Small molecules impart their action by binding to pockets on the protein surface of their physiological …
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Evaluation of telomerase activity and telomerase inhibitors in Head and Neck cancer
Cancer is a major cause of morbidity and mortality with increasing incidence worldwide. Early detection of cancers and better treatments would improve the outcome for patients. The overall 5-year survival rates of head and neck squamous cell carcinoma have not improved in the past several decades …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
Altered metabolism is one of the hallmarks of cancer and is known to enable the proliferation and survival of cancer cells in changing microenvironments. Metabolic changes can be interrogated using non-invasive metabolic imaging techniques, which enable the investigation of tumour metabolism in …
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Semantic text classification for cancer text mining
Cancer researchers and oncologists benefit greatly from text mining major knowledge sources in biomedicine such as PubMed. Fundamentally, text mining depends on accurate text classification. In conventional natural language processing (NLP), this requires experts to annotate scientific text, which …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
Cancer is characterized by a deregulation of the cell cycle resulting in abnormal proliferation of cells that can bypass tightly regulated molecular checkpoints. Breast cancer is the most common cancer diagnosed in women, ~70% of cases displaying an estrogen receptor positive (ER+) phenotype. The …
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Unravelling the potential applications of extracellular vesicles for the clinical management of melanoma patients
Metastatic melanoma is the third most common cancer in Australia with global incidence increasing. After decades without effective systemic treatments for advanced melanoma, the advent of targeted and immune therapies has substantially improved patient survival. While this is encouraging, further …
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