Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Hair growth"”.
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Prolactin signalling in murine hair growth
Although prolactin has been shown to entrain hair growth cycles in seasonally responsive mammals, no comparable role has been identified in the age-dependent pelage replacement of rodents. Prolactin binds to dimerised membrane-associated prolactin receptors (PRLR) on target organs and initiates …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
The hair follicle (HF) is a cyclic biological system that progresses through stages of growth, regression and quiescence, each being characterized by unique patterns of gene activation and silencing. MicroRNAs (miRNAs) are critically important for gene silencing and delineating their role in hair …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… role of PRC2 in human epidermal homeostasis and hair growth. The expression of EZH2 was elevated in differentiating suprabasal layers of the human epidermis. Consistently, EZH1/2 expression and enzymatic activity was upregulated in differentiating primary human keratinocytes (NHEKs) in vitro. …
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Gene expression underlying ferret hair growth initiation induced by melatonin and modified by steroids
… for studying gene expression associated with the hair growth cycle. The effects of melatonin and steroids on hair follicle growth initiation in flank skin samples were monitored by histology and immunocytochemistry. Melatonin implantation initiated hair growth within 10 days. Exogenous steroids …
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Development of a novel, clinically-relevant model for investigating factors that stimulate human hair growth
Lack of hair due to alopecia or skin grafting procedures causes significant distress due to hair's role in social and sexual communication. Only limited pharmacological agents are currently available to stimulate hair growth; their development is hampered by inappropriate model systems. Most …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… their role in regulation of apoptosis and hair loss in alopecia areata (AA) is largely unknown, which became the aim of this study. In AA mouse model (C3H/HeJ), global miRNA profiling revealed 22 miRNAs with significant changes in their expression in AA affected skin. Amongst these miRNAs, …
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Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth
… rise of commercial devices for management of hair growth, where all of them are based on low levels of light resulting into photobiological, non-thermal interaction of photons with cells, a process that recently has received an official term ‘photobiomodulation’. However, the design and …
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Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
… harmful microbes and prevents dehydration. While hair follicle stem cells (HFSCs) normally regenerate hair, they must also reconstruct and thereafter maintain the overlying epidermis upon a barrier breach, such as a wound. How these fate choices are balanced to restore physiologic function to …
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.
Hair disorders cause significant distress. The main, but limited, treatment for hair loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… differentiation in mice and humans and for hair follicle stem cell activation during mouse hair follicle regeneration and cutaneous wound healing. However, the role of SWI/SNF complexes in human hair growth and wound healing remain unknown. Here it is demonstrated that genes encoding SWI/SNF …
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
Androgens are the main regulators of human hair growth stimulating larger, terminal hair development e.g. beard and causing scalp balding, androgenetic alopecia. Hair disorders cause psychological distress but are poorly controlled. Androgens probably act by altering regulatory paracrine factors …
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Applications of Hair as a Record of Systemic Exposure to Cortisol
Hair cortisol content (HCC) is a novel biomarker that uniquely captures retrospective systemic cortisol exposure. This thesis aimed to assess how different hair growth rates effect HCC timelines in Cushing’s and Addison’s patients, investigate the relationship between HCC and age, puberty, sex and …
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Phosphate starvation alters calcium signalling in roots of Arabidopsis thaliana
… was compiled and screened for aberrant root hair growth under P starvation conditions. No mutant line showed aberrant root hair growth. These results indicate that P starvation strongly affects stress-induced [Ca2+]cyt modulations. The data generated in this thesis further understanding of …
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Assessing the role of probiotics for the enhancement of soil quality under cover crops
… Probiotics are believed to improve plant growth, root development and production of plant growth promoting substances. The main objective of this study was to quantify the effects of SCD Probiotics (Bio-Ag) on soil quality (SQ; microbial biomass, microbial communities, enzymatic activity) …
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Summer wolf diet in northwestern Montana
… or through stable isotope analysis (SIA) of wolf hair when distinct δ13C and δ15N values of potential diet sources are known. Our objectives were to compare diet analysis methods, to estimate intra-population diet variability, and to determine proportions of prey consumed by wolves. We collected …
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Summer wolf diet in northwestern Montana
… or through stable isotope analysis (SIA) of wolf hair when distinct δ13C and δ15N values of potential diet sources are known. Our objectives were to compare diet analysis methods, to estimate intra-population diet variability, and to determine proportions of prey consumed by wolves. We collected …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
Female ageing leads to reduced hair density and thinner fibres. The impact of the ageing dermal environment on the hair follicles (HFs) remains unclear. This study documents in situ changes in human female scalp skin of women (19-81 years (yrs)), and corresponding primary cultures of dermal …
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Studies of E2s Related to Unconventional Ubiquitination in Arabidopsis thaliana
… and overexpression of ARF6 enhanced the root hair growth in WT plants and partially rescued the root phenotypes of the ubc13 mutant. A major part of this study was on Arabidopsis UBC22, a sole member of an Arabidopsis E2 subfamily. Results from the phylogenetic analysis and in vitro …
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Specification And Function Of Early Hair Follicle Stem Cells
… reside in a quiescent niche associated with each hair follicle termed the "bulge" and are essential for cyclic bouts of hair growth. Bulge stem cells can also contribute to sebaceous glands and the intefollicular epidermis when it is injured. While hair follicles begin to develop during …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… domain in adult mice results in severe hair growth defects. I found that NuMA is required for proper spindle positioning in hair follicle matrix cells and that differentiation of matrix-derived progeny is disrupted when NuMA is mutated, thus revealing an essential role for spindle …
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