Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Hair follicles"”.
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Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
… All Epi-Insig-DKO mice failed to grow body hair, had decreased body weights, and died 6 weeks after birth. Early hair follicle development was normal while later development was disrupted and led to hair cycle arrest in these mice. Skin from these mutant mice showed a significant buildup of …
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… without the formation of skin appendages and hair follicles. In normal embryonic development hair follicle formation requires the interaction between epithelial (keratinocytes) and mesenchyme cells. Attempts to recapitulate the process of hair induction in wounded skin in vitrousing human …
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Coordinating Stem Cell Behavior in the Hair Follicle
… tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a process that is accomplished with the support of stem cells within the hair follicles. It is this feature that makes this miniorgan an attractive model system to …
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Expression pattern and role of Foxcl during hair follicle morphogenesis
… expressed in the epithelial cells of the hair follicles at all stages of embryonic skin development. In the developing hair follicles Foxcl promoter activity is induced at high levels in the post-mitotic precursor cells of the hair shaft, inner root sheath and sebaceous gland of the pelage …
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Development of a novel, clinically-relevant model for investigating factors that stimulate human hair growth
Lack of hair due to alopecia or skin grafting procedures causes significant distress due to hair's role in social and sexual communication. Only limited pharmacological agents are currently available to stimulate hair growth; their development is hampered by inappropriate model systems. Most …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between the anagen growth phase, a transitional catagen phase, and the dormant phase of telogen throughout life. We hypothesized that the defect in progression through catagen resulting from EGFR …
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RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals
… for epidermal differentiation, maintenance of hair follicle morphology and terminal differentiation of the inner and outer root sheath cells. Ligand-dependent activation, gamma-secretase-dependent cleavage, and RBPjk-mediated downstream transcriptional activities of Notch receptors constitute …
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
Androgens are the main regulators of human hair growth stimulating larger, terminal hair development e.g. beard and causing scalp balding, androgenetic alopecia. Hair disorders cause psychological distress but are poorly controlled. Androgens probably act by altering regulatory paracrine factors …
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Dissecting adult epithelial cell plasticity using a model of oesophageal-to-skin lineage conversion
… the mouse skin dermis, bearing empty niches for hair follicles. Whole-mount techniques together with immunofluorescence analysis revealed that oesophageal cells re-epithelialized the skin dermis and underlying niches, forming a new epithelium with associated appendages structurally similar to …
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.
Hair disorders cause significant distress. The main, but limited, treatment for hair loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to …
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Molecular Regulation of Hair Follicle Morphogenesis
… cells during embryogenesis. Morphogenesis of hair follicles is initiated when a series of reciprocal interactions between this undifferentiated ectoderm and its underlying mesenchyme leads to a localized invagination of epithelial cells. As hair follicle development proceeds, stem cells are …
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A Comparison of Cultured Human Dermal Fibroblasts Derived from Terminal and Vellus Hair Bearing Skin. Differences in the expression of inhibitors of apoptosis proteins, oestrogen receptors, and responses to oestradiol under normal and wound induced conditions
Wounds heal better in skin with terminal hair follicles (large and pigmented) as opposed to those with vellus hair follicles (small and unpigmented), while dermal fibroblasts from different anatomical regions also exhibit phenotypical differences. Tissue repair requires a tight control of cell …
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A GENETIC COMPARISON OF PITUITARY PARS INTERMEDIA DYSFUNCTION POSITIVE & NEGATIVE EQUINES AT DBH, TO AID IN THE DEVELOPMENT OF GENETIC DIAGNOSTIC PROTOCOLS.
… hormone tests. Using DNA extracted from equine hair follicles, the dopamine beta-hydroxylase gene (DBH) was studied as a candidate gene for association with PPID. Preliminary research indicates high levels of variation in all animals sampled, with no correlation to PPID, indicating further …
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The Genetic Architecture of Alopecia Areata
… In AA, autoimmunity arises against the hair follicles in the skin, which causes hair loss associated with an aberrant accumulation of immune-response cells around the affected hair follicles. Evidence supporting a genetic basis for AA stems from multiple lines of research, including …
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The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster
… stratified squamous epithelium with no glands or hair follicles in its wall, thus rendering it less susceptible to cyclic changes than more complex tissues, in which accessory structures are present.
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WNT SIGNALING AND HAIR FOLLICLE INITIATION
… of the skin, and provides inductive cues for hair follicle initiation. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning …
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Influence of transdermal current flow in tDCS-induced cutaneous adverse events
… (blood vessels, sweat glands, and hair follicles) in current flow. The finite element modeling (FEM) of current flow using simplified tissue geometries predict higher current density at the electrode edge, but the experimental evidences for the cutaneous effects of tDCS (skin …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… differentiation in mice and humans and for hair follicle stem cell activation during mouse hair follicle regeneration and cutaneous wound healing. However, the role of SWI/SNF complexes in human hair growth and wound healing remain unknown. Here it is demonstrated that genes encoding SWI/SNF …
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… important role during the morphogenesis of the hair follicle and the hair cycle. Work on hair regeneration is of importance as no products are available which can provide complete reversal of hair loss. Tet2 promotes DNA demethylation by the hydroxylation of 5mC to 5hmC which in turn causes gene …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… arise from keratinocytes of the epidermis or hair follicles. Current treatments are limited, especially for pre-cancerous lesions. Homeostasis and differentiation of the skin is regulated through calcium-associated signaling. Better understanding the role of calcium regulation in the epidermis …
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