Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Hair follicle"”.
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Molecular Regulation of Hair Follicle Morphogenesis
… cells during embryogenesis. Morphogenesis of hair follicles is initiated when a series of reciprocal interactions between this undifferentiated ectoderm and its underlying mesenchyme leads to a localized invagination of epithelial cells. As hair follicle development proceeds, stem cells are …
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WNT SIGNALING AND HAIR FOLLICLE INITIATION
… of the skin, and provides inductive cues for hair follicle initiation. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
… these signals can result in disruption in hair follicle architecture, lack of differentiated cells and disease.</p> <p>Cells are able to transmit extracellular signals from the cell membrane to the actin cytoskeleton through the adherens junctions (AJ). The AJ is composed of the core …
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Coordinating Stem Cell Behavior in the Hair Follicle
… tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a process that is accomplished with the support of stem cells within the hair follicles. It is this feature that makes this miniorgan an attractive model system to …
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Specification And Function Of Early Hair Follicle Stem Cells
… reside in a quiescent niche associated with each hair follicle termed the "bulge" and are essential for cyclic bouts of hair growth. Bulge stem cells can also contribute to sebaceous glands and the intefollicular epidermis when it is injured. While hair follicles begin to develop during …
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Specification of Stem Cells and Niche During Hair Follicle Morphogenesis
… I focused my analysis on the earliest stages of hair follicle (HF) morphogenesis. Using immunofluorescence and live imaging, I found that in developing HFs, basal cell divisions are asymmetric and perpendicular to the basement membrane. These divisions result in differential levels of WNT …
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Expression pattern and role of Foxcl during hair follicle morphogenesis
… expressed in the epithelial cells of the hair follicles at all stages of embryonic skin development. In the developing hair follicles Foxcl promoter activity is induced at high levels in the post-mitotic precursor cells of the hair shaft, inner root sheath and sebaceous gland of the pelage …
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Investigation of regulatory functions of micrornas in skin and hair follicle development and cycling. A role of microRNA-214 in skin and hair follicle homeostasis.
… of physiological processes, including skin and hair follicle (HF) development. In this study, the role for miR-214 in the skin and HF development and their postnatal physiological regeneration was investigated. miR-214 exhibits discrete expression patterns in the epidermis and HF in developing …
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… important role during the morphogenesis of the hair follicle and the hair cycle. Work on hair regeneration is of importance as no products are available which can provide complete reversal of hair loss. Tet2 promotes DNA demethylation by the hydroxylation of 5mC to 5hmC which in turn causes gene …
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Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells
… lacks a dermal layer and skin adnexae including hair follicles and sebaceous glands. This results in a loss of pliability and contractures that cause functional and cosmetic impairment. Embryological hair follicle morphogenesis results from a complex series of mesenchymal-epithelial interactions …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
Female ageing leads to reduced hair density and thinner fibres. The impact of the ageing dermal environment on the hair follicles (HFs) remains unclear. This study documents in situ changes in human female scalp skin of women (19-81 years (yrs)), and corresponding primary cultures of dermal …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… their role in regulation of apoptosis and hair loss in alopecia areata (AA) is largely unknown, which became the aim of this study. In AA mouse model (C3H/HeJ), global miRNA profiling revealed 22 miRNAs with significant changes in their expression in AA affected skin. Amongst these miRNAs, …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
… I investigated this issue using the adult murine hair follicle stem cell (HFSC) as my paradigm. HFSCs reside in their niche called the bulge, and mostly remain in a quiescent state, becoming mobilized only transiently to fuel cyclical bouts of hair follicle regeneration. By ablating a key HFSC …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between the anagen growth phase, a transitional catagen phase, and the dormant phase of telogen throughout life. We hypothesized that the defect in progression through catagen resulting from EGFR …
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RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals
… for epidermal differentiation, maintenance of hair follicle morphology and terminal differentiation of the inner and outer root sheath cells. Ligand-dependent activation, gamma-secretase-dependent cleavage, and RBPjk-mediated downstream transcriptional activities of Notch receptors constitute …
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Biochemical studies on trichohyalin : the origin of the citrulline-containing proteins in the hair follicle / by Joseph Attila Rothnagel
Offprints of the author's articles inserted
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Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth
… rise of commercial devices for management of hair growth, where all of them are based on low levels of light resulting into photobiological, non-thermal interaction of photons with cells, a process that recently has received an official term ‘photobiomodulation’. However, the design and …
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Gene expression underlying ferret hair growth initiation induced by melatonin and modified by steroids
… for studying gene expression associated with the hair growth cycle. The effects of melatonin and steroids on hair follicle growth initiation in flank skin samples were monitored by histology and immunocytochemistry. Melatonin implantation initiated hair growth within 10 days. Exogenous steroids …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… differentiation in mice and humans and for hair follicle stem cell activation during mouse hair follicle regeneration and cutaneous wound healing. However, the role of SWI/SNF complexes in human hair growth and wound healing remain unknown. Here it is demonstrated that genes encoding SWI/SNF …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… of Stat3 specifically in the bulge region of the hair follicle using K15.CrePR1 X Stat3<sup>fl/fl </sup>mice led to decreased tumor development by altering survival of bulge region KSCs. To further understand the role of KSCs in skin tumorigenesis, K5.Stat3C transgenic (Tg) mice which express a …
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